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find Keyword "内侧颞叶癫痫" 6 results
  • HCN single nucleotide polymorphism and genetic susceptibility of medial temporal lobe epilepsy

    ObjectiveThrough Sequenom iPEX system analyzed the genetic susceptibility in patients with Medial temporal lobe epilepsy (MTLE) which screening hyperpolarization-activated cyclic nucleotide gated channel (HCN) subunit HCN1 and HCN2 single nucleotide polymorphism blood samples. MethodsPatients with epilepsy who were diagnosed MTLE in our epileptic clinic from December 2013 to April 2016 were included in this study, total 143 cases. Healthy volunteers who received annual physical checkups were recruited to serve as controls total 120 cases. The group enter criterion according to a 2004 ILAE report mainly:①12~55 years old; ②attack forms:partial onset seizures or secondary tonic-closure-clonus attack, a common onset symptoms such as stomach gas rise feeling, sense of deja vu, automatism etc.; ③with or without febrile convulsions history; ④EEG displayed unilateral or bilateral temporal spike, sharp slow wave, or their spines slow-wave sample such as epilepsy wave; ⑤head MRI displayed hippocampal sclerosis. Exclusion criteria:①tumors; ②head MRI display focal cortical dysplasia (FCD). Using sequenom iPLEX technology platform to detect all the object of study of gene polymorphism sites total ten sites. All statistical tests were conducted using SPSS version 16.0. Resultsall sites fulfilled Hardy-Weinberg genetic balance. The results showed that HCN1 rs17344896 C/T, rs6451973 A/G and HCN2 rs12977194 A/G three polypeptide sites associated with MTLE, with statistical differences(P < 0.05). ConclusionHCN1 and HCN2 genetic suscepibility is one of possible mechanism of MTLE.

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  • 人类疱疹病毒6与难治性癫痫相关性的研究进展

    癫痫是神经系统疾病中常见疾病,根据国内外流行病学调查,超过80%的癫痫患者生活在发展中国家。目前,我国有约900万癫痫患者,其中难治性癫痫(Intractable Epilepsy,IE)患者占所有癫痫患者的30%左右。频繁的癫痫发作严重伤害了患者的身体健康,致患者生活质量低下,死亡率显著增高。迄今为止,IE的发病机制尚不明确。近年研究发现,人类疱疹病毒6型(Human herpes virus 6, HHV-6)与IE的发生相关,文章就HHV-6在癫痫发病中的作用进行综述。

    Release date:2017-11-27 02:36 Export PDF Favorites Scan
  • 微小 RNA 和伴海马硬化的内侧颞叶癫痫:人类海马全微小 RNA 组谱

    内侧颞叶癫痫(mesial temporal lobe epilepsy, mTLE)是一种严重的以反复癫痫发作为特征的神经系统疾病。mTLE 通常伴有海马神经元变性导致的海马硬化(Hippocampal sclerosis,HS), 它是与 mTLE 患者耐药性相关的最常见的形态学改变。对 mTLE+HS 的认识不足使其治疗复杂化。mTLE+HS 的潜在病理机制可能涉及异常的基因表达调控,包括涉及微小 RNA(microRNA, miRNA)的转录后网络。 miRNA 表达调控在包括癫痫的多种疾病中都有报道。但是,mTLE+HS 的 miRNA 谱暂未被完全了解,需要进一步解决。在此,为了揭示 miRNA 的异常表达,我们关注了 33 例 mTLE+HS 患者和 9 具对照者尸检的海马 miRNA 分析。研究中,通过联合两种不同的 miRNA 分析方法,以及下一代测序技术和 miRNA 特异性实时定量聚合酶链式反应,我们显著降低了技术相关的偏移(最常见的是 miRNA 分析数据的假阳性)。这些方法结合起来明确并验证了 20 例癫痫患者海马中 miRNA 的表达改变。在 mTLE+HS 患者中,有 19 例 miRNA 上调,1 例下调。其中 9 种 miRNA 以往没有报道与癫痫有联系,19 例异常表达的 miRNA 可能调节与癫痫相关的靶点和通路(例如:钾离子通道,γ-氨基丁酸,神经营养因子信号传导和轴突导向)。研究通过明确 miRNA 在 mTLE+HS 中表达,扩展了当前对 mTLE+HS 中 miRNA 介导的基因表达调控的认知,包括 9 个新发现的 miRNA 异常表达及其可能的靶点。 这些发现进一步提升了基于 microRNA 的生物标志物或疗法的可能性。

    Release date:2018-03-20 04:09 Export PDF Favorites Scan
  • 良性内侧颞叶癫痫的研究进展

    颞叶癫痫(TLE)是指异常过度放电起源于一侧或双侧颞叶结构的癫痫,是最常见的成人局灶性癫痫,也是最常见的药物难治性癫痫。内侧(Mesial)TLE 是 TLE 的主要类型,手术切除致痫灶是有效治疗方法。然而,部分患者的症状则较轻,并且能够在服用或未服用抗癫痫药物治疗的情况下达到无限期的缓解期,被认为是良性(benign)MTLE,此类患者经常有发热发作和癫痫的家族史。目前研究者认为 MTLE 可能与海马硬化和遗传因素有关,文章就 bMTLE 的研究进展进行总结,以提高临床对其认识。

    Release date:2019-01-19 08:54 Export PDF Favorites Scan
  • Altered spontaneous brain activity in mesial temporal lobe epilepsy with unilateral hippocampal sclerosis: a meta-analysis of resting-state functional magnetic resonance imaging

    Objective To identify the most consistent and replicable characteristics of altered spontaneous brain activity in mesial temporal lobe epilepsy patients with unilateral hippocampal sclerosis (MTLE-HS). Methods A systematic literature search was performed in PubMed, Embase, The Cochrane Library, China National Knowledge Infrastructure, Wanfang, and CQVIP databases, to identify eligible whole-brain resting state functional magnetic resonance imaging studies that had measured differences in amplitude of low-frequency fluctuations or fractional amplitude of low-frequency fluctuations between patients with MTLE-HS and healthy controls from January 2000 to January 2019. After literature screening and data extraction, Anisotropic Effect-Size Signed Differential Mapping software was used for voxel based pooled meta-analysis. Results Nine datasets from six studies were finally included, which contained 207 MTLE-HS patients and 239 healthy controls. The results demonstrated that, compared with the healthy controls, the MTLE-HS patients showed increased spontaneous brain activity in right hippocampus and parahippocampal gyrus, right superior temporal gyrus, left cingulate gyrus, right fusiform gyrus, and right inferior temporal gyrus; while decreased spontaneous brain activity in left superior frontal gyrus, right angular gyrus, right middle frontal gyrus, left inferior parietal lobule, left precuneus, and right cerebellum (P<0.005, cluster extent≥10). Conclusion The current meta-analysis demonstrates that patients with MTLE-HS show increased spontaneous brain activity in lateral and mesial temporal regions and decreased spontaneous brain activity in default mode network, which preliminarily clarifies the characteristics of altered spontaneous brain activity in patients with MTLE-HS.

    Release date:2019-11-25 04:42 Export PDF Favorites Scan
  • 超极化激活环核苷酸门控通道在颞叶癫痫的研究新进展

    超极化激活环核苷酸门控通道(Hyperpolarizationactivated cyclic nucleotide gatedchannel,HCN)属于电压门控型离子通道,迄今为止发现有四个亚型:HCN1~HCN4。HCN 通道的激活依赖于膜的超级化,在膜电位低于静息电位时,HCN 通道被激活,产生局部紧张性电流,导致持续的钠内流,使细胞膜发生去极化。该通道分布在人体的分布并不一致,主要在神经系统和心脏中表达。目前研究表明,HCN 通道既参与所在组织的正常生理功能,如睡眠和觉醒、学习和记忆、视觉和疼痛感知、神经元起搏、树突整合等,也与多种中枢神经系统疾病及所在组织的病理状态密切相关,如神经病理性疼痛、学习记忆障碍、药物成瘾和颞叶癫痫,特别是在伴海马硬化性内侧颞叶癫痫中。癫痫作为神经系统最常见的神经疾病之一,癫痫因其病因错综复杂,病理改变亦多样性,至今尚未能完全了解其全部发病机制。目前有大量的文献报道 HCN 与癫痫,特别是颞叶癫痫的发生发展有密切关系。因此本文就 HCN 通道的结构特征、分布、功能、调控及其在颞叶癫痫发生过程中的新研究进展进行综述。

    Release date:2020-03-20 08:06 Export PDF Favorites Scan
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