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find Keyword "分子分型" 8 results
  • Molecular Classification and Early Prediction of Metastasis and Recurrence for Hepatocellular Carcinoma

    Release date:2016-08-28 04:08 Export PDF Favorites Scan
  • Discussion on Relation Between Plasma Homocysteine and Breast Cancer

    Objective To explore the correlation between homocysteine (Hcy) level and the risk of breast cancer,and try to find a new method to reduce the risk factors and benefit for treatment of breast cancer. Methods From January2010 to December 2012, 245 cases of breast cancer (breast cancer group), 109 cases of benign breast tumor (benign breast tumor group), and 78 cases of healthy women (healthy control group) in the Sichuan Provincial People’s Hospital, who were in accordance with the inclusion criteria, were analyzed retrospectively. The difference of Hcy level was compared among three groups. Meanwhile the relation between Hcy level and patients’s age, blood glucose, serum creatinine, estrogen receptor (ER), progesterone receptor (PR), Ki-67 (%), tumor diameter, or axillary lymph node status was analyzed.Results ① The Hcy level was significantly different among the breast cancer group, benign breast tumor group, and healthy control group (P<0.001). The Hcy level of the breast cancer group was significantly higher than those of the benignbreast tumor group (P<0.001) or healthy control group (P<0.001), but the Hcy level was not significantly different bet-ween the benign breast tumor group and healthy control group (P=0.082) . ② The Hcy levels of different types of the breastcancer (type of Luminal A, Luminal B, Her-2, and triple negative) were significantly higher than those of the benign breast tumor group (except for Her-2 type, P<0.05) or healthy control group (P<0.05). ③Plasma Hcy level of the patients with benign and malignant breast tumor was positively correlated with age (r=0.197, P=0.004) or serum creatinine level (r=0.381, P<0.001), but not correlated with blood glucose (r=0.023, P=0.668). ④Plasma Hcy level of the patients with malignant breast tumor was positively correlated with age (r=0.267, P=0.007) or serum creatinine level (r=0.341, P<0.001), but not correlated with blood glucose (r=-0.005, P=0.935), tumor diameter (r=-0.049, P=0.443), axillary lymph node status (r=-0.006, P=0.921), or Ki-67 (%) (rs=-0.029, P=0.650). Conclusions Plasma Hcy level of breast cancer patient is abnormally elevated, and it may have some relation with the occurrence of breast cancer.

    Release date:2016-09-08 10:35 Export PDF Favorites Scan
  • Relation Between Molecular Subtypes and Neoadjuvant Chemotherapy Efficacy in Breast Cancer

    ObjectiveTo explore the relation between the molecular subtypes and efficacy of neoadjuvant chemotherapy with docetaxel together with epirubicin(TE) in breast cancer. MethodsAccording to the inclusion and exclusion criteria, 239 patients with breast cancer who at least received 3 cycles of TE-based neoadjuvant chemotherapy from May 2011 to December 2012 in this hospital were included. Molecular subtypes were categorized into luminal A, luminal B, human epidermal growth factor receptor 2(HER-2) positive, and triple negative by the immunohistochemical results of estrogen receptor(ER), progesterone receptor(PR), HER-2, and Ki-67 status. The relevant indicators of the different molecular subtypes of breast cancer patients, such as pathological complete response(pCR) rate, age, and menstruation, etc. were analyzed. ResultsThere were 67(28.03%) patients with luminal A, 84(35.15%) luminal B, 21(8.79%) HER-2, and 67(28.03%) triple negative in these 239 patients with breast cancer. The differences of age, menstruation, axillary lymph node status etc. among the four molecular subtypes were not statistically significant(P > 0.05). The pCR rate of triple negative breast cancer(14.93%) was the highest among four subtypes, followed by luminal B(7.14%), HER-2 positive(4.76%) and luminal A(1.49%), there was a significant difference(P=0.027). ConclusionsComparing with luminal A, luminal B, and HER-2 positive breast cancers, triple negative breast cancer is the most sensitive to TE neoadjuvant chemotherapy, and it has the highest pCR rate. Therefore, different treatment should be selected according to molecular subtypes of breast cancer.

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  • Molecular Classification of Breast Cancer and Surgical Management of Axiuary Lymph Node

    ObjectiveTo explore influence of molecular classification of breast cancer on surgical treatment of axillary lymph nodes. MethodThe related literatures which discussed the relation between molecular classification and axillary lymph node metastasis were reviewed and analyzed. ResultsThe triple negative breast cancer had a lower rate of sentinel lymph node or non-sentinel lymph node metastasis. The axillary lymph node metastasis rate was higher in the luminal B or HER-2 overexpression subtypes. Especially, luminal B subtype had a higher risk of sentinel lymph node or non-sentinel lymph node metastasis as compared with the other subtypes. Elderly patients with breast conserving operation could be free for axillary lymph node dissection when only 1-2 sentinel lymph node metastases. There was still a positive possibility of non-sentinel lymph node for younger patients with a larger tumor size, even if the sentinel lymph node negative, the lymph node dissection may benefit these patients. ConclusionBreast cancer molecular classification should be considered for the surgery selection of axillary lymph node dissection.

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  • 三阴性乳腺癌的临床病理特征及治疗进展

    三阴性乳腺癌(triple-negative breast cancer,TNBC)是乳腺癌中的一种特殊免疫组织化学亚型,以雌激素受体、孕激素受体及人类表皮生长因子受体 2 阴性表达为特征。TNBC 具有高度异质性且通常发病早、临床分期较晚、组织学级别高、易于局部复发、转移并且预后差等特点。由于其不表达雌激素受体、孕激素受体和人类表皮生长因子受体 2,不能从内分泌治疗和抗人类表皮生长因子受体 2 靶向治疗中受益,故其治疗手段相对于其他类型乳腺癌亦受到相应的限制。自 TNBC 的概念提出后已成为乳腺癌研究和关注的焦点。该文对 TNBC 临床病理特征、分子生物学特点及治疗最新进展作了综述。

    Release date:2017-02-22 03:47 Export PDF Favorites Scan
  • Therapeutic effect of endocrine therapy in breast cancer patients with negative hormone receptor of primary lesion and positive hormone receptor of metastatic axillary lymph node lesion

    Objective To explore therapeutic effect of endocrine therapy in breast cancer patients with negative hormone receptor (HR–) of primary lesion and positive HR (HR+) of metastatic axillary lymph node lesion. Methods Sixty-seven cases of breast cancer with HR– of primary lesion and HR+ of metastatic axillary lymph node lesion from January 2011 to January 2016 were selected. All the patients were randomly divided into endocrine therapy group (33 cases) and control group (34 cases). The patients were given the oral drug of tamoxifen on the basis of conventional chemotherapy in the endocrine therapy group after the surgery, 10 mg/time, twice daily, 5 years; while the patients in the control group were not given the oral drug of tamoxifen but the other therapy same as the endocrine therapy group. The survivals were compared in both groups. Results There were no significant differences in the age, menstrual condition, tumor diameter, preoperative TNM stage, and so on between the endocrine therapy group and the control group (P>0.05). All the patients were followed up for 12–60 months with a 48.5 months of median time. There were no significant differences in the rates of the local recurrence and metastasis, or death rate due to the recurrence and metastasis in both groups (P>0.05). The progression-free survival and overall survival in the endocrine therapy group were significantly higher than those in the control group (P<0.05). The 5-year cumulative progression-free survival and overall survival in the endocrine therapy group were significantly better than those in the control group (P<0.05). Conclusion Pay attention to molecular classification of primary lesion and metastatic axillary lymph node lesion in patients with breast cancer, and endocrine therapy might be able to improve survival rate of breast cancer patients with primary lesion HR– and metastatic axillary lymph node lesion HR+.

    Release date:2018-02-05 01:53 Export PDF Favorites Scan
  • The relationship between the expression of PTEN/Basigin1 protein and clinicopathological features in breast cancer

    Objective To investigate the expression of phosphate and tension homology deleted on chromsome ten (PTEN) and Basigin1, as well as their relationships with clinicopathological factors and molecular subtypes in invasive ductal carcinoma of breast. Methods The expressions of PTEN and Basigin1 protein were examined in 76 invasive ductal carcinoma of breast tissues by immunohistochemical method, and 20 breast benign hyperplasia tissues as control. These 76 patients underwent surgery in our hospital from Jan. 2014 to Dec. 2015. Results The high-expression rate of PTEN protein in invasive ductal carcinoma of breast tissues was lower than that in benign hyperplasia tissues [56.6% (43/76) vs. 85.0% (17/20), χ2=5.457, P=0.019], while the high-expression rate of Basigin1 protein was higher than that of the benign hyperplasia tissues [51.3% (39/76) vs 25.0% (5/20), χ2=4.417, P=0.036]. The high-expression of PTEN protein was positively correlated with WHO grade and lymph node metastasis status (P<0.05). The high-expression of Basigin1 protein was positively correlated with WHO grade, lymph node metastasis status, and TNM stage (P<0.05). In addition, the high-expression of PTEN protein was associated with molecular subtypes of breast cancer (P<0.001), and its high-expression rate was higher in Luminal A and Luminal B patients; the high-expression of Basigin1 protein was associated with molecular subtypes of breast cancer too (P<0.001), and the high-expression rate of Basigin1 protein was higher in Her-2 overexpression and basal-like subtypes of breast cancer patients. Spearman correlation analysis shown that expression of PTEN protein was negatively correlated with expression of Basigin1 protein (rs=–0.481, P<0.001). Conclusion PTEN and Basigin1 protein may have some mechanisms to promote the occurrence and development of breast cancer, which provide a new basis for targeted treatment of breast cancer.

    Release date:2020-07-26 02:35 Export PDF Favorites Scan
  • Correlation between lipid profile and molecular typing of invasive breast cancer

    ObjectiveTo explore the correlation between lipid profile and molecular typing of invasive breast cancer.MethodsThree hundreds and seventy-five patients with primary invasive breast cancer diagnosed from Breast Surgery, Affiliated Hospital of Southwest Medical University from January 2018 to June 2019. The total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C), apolipoprotein A (ApoA), and apolipoprotein B (ApoB) concentrations were detected. Molecular classification based on the results of postoperative immunohistochemistry of breast cancer patients, compared the measured values of each subtype.ResultsThere were no significant difference in serum TG, HDL-C and ApoA among the four subtypes (P>0.05). Differences serum levels of TC, LDL-C, and ApoB among breast cancer patients of various subtypes were statistically significant (P<0.05). Serum TC concentration in the HER2 overexpression type [(5.08±1.00) mmol/L] and the triple negative type [(5.12±0.91) mmol/L] were significantly higher than the Luminal A type [(4.68±1.01) mmol/L] and the Luminal B type [(4.79± 0.93) mmol/L], P<0.05. Serum LDL-C concentration in the triple negative type [(3.14±0.88) mmol/L] was significantly higher than the LuminalA type [(2.77±0.84) mmol/L] and the LuminalB type [(2.87±0.81) mmol/L], P<0.05. Serum ApoB concentration in the Luminal B type [(0.94±0.23) g/L] was significantly lower than the triple negative type [(1.03±0.23) g/L].ConclusionThere are differences in serum TC, LDL-C and apoB concentrations among different subtypes of breast cancer, but TG, HDL-C and ApoA are not related to molecular typing of breast cancer.

    Release date:2021-04-25 05:33 Export PDF Favorites Scan
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