west china medical publishers
Author
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Author "刘元元" 2 results
  • A Study on the Serum Procalcitonin Level after Conventional Intravenous Antibiotic Treatment to Predict the Risk of Re-exacerbation in Infectious Acute Exacerbation of Chronic Obstructive Pulmonary Disease

    ObjectiveTo evaluate the value of serum procalcitonin (PCT) level after conventional intravenous antibiotic treatment to predict the risk of re-exacerbation, and vertify the feasiblity of an additional course of oral antibiotics after discharge to reduce the risk of re-exacerbation. MethodsThe patients who hospitalized in West China Hospital from October 2012 to October 2013 because of infectious acute exacerbation of chronic obstructive pulmonary disease (AECOPD) were recruited. The concentrations of PCT and C-reactive protein (CRP), the number of white blood cell (WBC) and neutrophil percentage at the end of intravenous antibiotic therapy were recorded. The information about additional course of antibiotics was collected according to the medical instruction and visit. The subjects were followed up for 1 year.The time to the first re-exacerbation and frequencies of exacerbations were recorded. The Cox regression model was used to estimate the hazard rations (HR). ResultsOne hundred and thirty-eight eligible patients were included totally. The HRs in PCT≥0.11μg/L and neutrophil percentage≥70% were 1.462 (P=0.035) and 1.673 (P=0.005) respectively, suggesting higher risk of re-exacerbation. There was no relationship of CRP (P=0.330) or WBC (P=0.432) with the risk of re-exacerbation. Generally an additional course of antibiotics had no effects on re-exacerbation (P=0.231) but this therapy could reduce the risk of re-exacerbation in high PCT level group (HR=2.29, P=0.004). ConclusionsSerum PCT concentrations and neutrophil percentage after conventional intravenous antibiotic treatment can predict the risk of re-exacerbations in the future. An additional course of antibiotics in the patients with high PCT level can reduce the risk of re-exacerbation.

    Release date: Export PDF Favorites Scan
  • 痰培养联合曲霉血清学GM试验对诊断侵袭性曲霉感染的临床价值研究

    目的评价痰培养联合曲霉血清学半乳甘露聚糖(GM)试验对侵袭性曲霉感染的临床诊断价值。 方法对济宁医学院附属医院2012年7月至2013年7月间疑似曲霉感染的216例住院患者进行痰培养和血清ELISA检测。以临床诊断为标准, 评估痰培养和GM试验及联合检测的敏感性、特异性、阳性预测值和阴性预测值, 采用χ2检验进行比较。应用受试者工作特征曲线(ROC曲线)比较不同检测的疾病识别能力。 结果痰培养的敏感性和特异性为60.4%和69.9%, GM试验为94.3%和94.5%, 二者联合检测可将诊断的敏感性和特异性分别提高至98.1%和99.4%。联合检测的ROC曲线下面积(AUC)为0.960, 95%可信区间为0.929~0.992。 结论痰真菌培养联合血清GM抗原检测能大幅提高曲霉感染病例的临床诊断效率。

    Release date:2016-11-25 09:01 Export PDF Favorites Scan
1 pages Previous 1 Next

Format

Content