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find Author "刘媛媛" 4 results
  • Clinical significance of insulin like growth factor binding protein 3 in patients with lung cancer

    Objective To investigate the expressions of insulin like growth factor binding protein -3 ( IGFBP-3 ) in serum and bronchoalveolar lavagae fluids ( BALF ) of patients with non-small cell lung cancer , and explore the clinical significance in dignosis and prognosis of lung cancer.Methods The bronchoalveolar lavagae fluids ( BALF ) were collected by bronchoscopy in 80 cases with non-small cell lung cancer and 14 healthy subjects.The expression of IGFBP-3 in serum and BALF were detected by immunoradioassay.Results The expression of IGFBP-3 in serum and BALF of lung cancer group were significantly lower than that of health group(Plt;0.05).IGFBP-3 levels were significantly lower in those patients with lymphoid node metastasis or metastasis or TNMⅢ-TNMⅣ than those without metastasis or TNMⅠ-TNMⅡ(Plt;0.05).In lung cancer group,the levels of the IGFBP-3 in serum and BALF had a significantly positive correlation(r=0.415,r=0.355,Plt;0.01).Conclusion The IGFBP-3 may play an important role in the development of non-small cell lung cancer and is valuable in dignosis and prognosis of lung cancer.

    Release date:2016-09-14 11:52 Export PDF Favorites Scan
  • Soft tissue calcifications and ossifications observed by means of panoramic radiography

    Soft tissue opacities are often found by chance during radiographic examinations, especially in panoramic radiography. Because of the diversity of locations and causes, it is easily overlooked by dentists and even radiologists. Even if abnormal calcification is detected, it is difficult to identify its category and clinical relevance. For some soft tissue opacities associated with high-risk diseases, misdiagnosis is likely to delay treatment. Through reviewing the literature and screening the panoramic images from the disease database of West China Hospital of Stomatology, Sichuan University, this review summarizes and classifies the soft tissue opacities appearing in panoramic images, and discusses the clinical correlation to provide the reference for diagnosis, treatment, and prevention of related diseases.

    Release date:2019-06-25 09:50 Export PDF Favorites Scan
  • Distribution and Antibiotic Resistance of Isolates from Lower Respiratory Tract in Mechanically Ventilated Patients with COPD

    Objective To investigate the distribution and antibiotic resistance of pathogens isolated fromlower respiratory tract in mechanically ventilated patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD) . Methods The patients with AECOPD, who were hospitalized in RICU from January 2008 to November 2009, were divided into a community infection group and a nosocomial infection group. Lower respiratory tract isolates were collected by bronchoscopic protected specimen brush for bacterial identification and susceptibility test. Results 134 cases were enrolled in the study, with 75 cases in thecommunity infection group and 59 cases in the nosocomial infection group. The positive detection rate in the nosocomial infection group was significantly higher than that in the community infection group [ 81. 4%( 48/59) vs. 54. 7% ( 41/75) ] . In the community infection group, 49 strains were isolated, in which gramnegativebacteria, gram-positive bacteria, and fungi accounted for 55. 1% , 28. 6% , and 16. 3% , respectively.In the nosocomial infection group, 55 strains were isolated, in which gram-negative bacteria, gram-positive bacteria, and fungi accounted for 61. 8% , 21. 8% , and 16. 4%, respectively. There was no significant difference in the microbial distribution between the two groups ( P gt; 0. 05) . The detection rate of ESBLs producing strains in the nosocomial infection group was significantly higher than that in the community infection group ( 58. 8% vs. 37% ) . The resistance rates in the nosocomial groups were higher than those in the community infection group. Conclusions Antibiotic resistance is serious in mechanically ventilated patients with AECOPD, especially in the nosocomial infection patients. The increased fungi infection and drug resistance warrant clinicians to pay more attention to rational use of antibiotics, and take effective control measures.

    Release date:2016-08-30 11:53 Export PDF Favorites Scan
  • KL-6联合肺功能在多发性肌炎/皮肌炎合并间质性肺疾病中的应用价值

    目的 探讨血清KL-6和肺功能检测在多发性肌炎(polymyositis,PM)/皮肌炎(dermatomyositis,DM)合并间质性肺疾病(interstitial lung disease,ILD)中的临床应用价值。方法 采用回顾性分析,纳入初发PM/DM患者(n=64)临床资料,分为间质肺组(n=40)和无间质肺组(n=44),另选健康对照组40例,比较三组患者血清KL-6水平及肺功能在两组的差异并分析其在PM/DM-ILD组中的应用价值。结果 间质肺组患者KL-6水平明显高于无间质肺组(P<0.01);间质肺组患者VC%pred、MVV%pred、FEV1%pred、DLCO%pred、DLCO/VA%pred、TLC%pred均低于无间质肺组(P均<0.05);ROC曲线分析得出PM/DM患者中血清KL-6诊断ILD敏感性为84%,特异性为87.5%,DLCO%pred诊断ILD的敏感性为97.7%,特异性为57.5%,而二者联合检测敏感性为90.5%,特异性为82.5%;间质肺组血清KL-6与VC%pred、MVV%pred、FVC%pred、FEV1%pred、DLCO%pred成反比,与FEV1/FVC%pred成正比(P均<0.05);PM/DM发生ILD的危险因素:AST降低、KL-6升高及DLCO%pred降低。结论 PM/DM患者联合检测血清KL-6和肺弥散功能可提高ILD诊断效能,KL-6和肺功能可能预测ILD的发生及疾病活动度,可指导临床。

    Release date:2024-01-06 03:59 Export PDF Favorites Scan
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