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find Author "刘小兰" 2 results
  • Efficacy and Safety of Piolitazone Combined with Metformin in Type 2 Diabetes Mellitus: A Meta-analysis

    ObjectiveTo evaluate the efficacy and safety of piolitazone combined with metformin for type 2 diabetes mellitus. MethodsThe Cochrane Library (Issue 9, 2015), PubMed, EMbase, CNKI, WanFang Data and VIP databases were searched up to September 2015 for randomized controlled trials (RCTs) about pioglitazone combined with metformin versus sulfonylurea combined with metformin for type 2 diabetes mellitus. Two reviewers independently screened literature, extracted date, and assessed the risk of bias of included studies. Then, meta-analysis was performed by using RevMan 5.3 software. ResultsA total of 7 RCTs involving 3 005 patients were included. The results of metaanalysis showed that when the course of treatment was ≤24 weeks, no significant difference was found in the level of HbA1c between the piolitazone plus metformin group and the sulphonylurea plus metformin group (MD=-0.04, 95%CI -0.26 to 0.19, P=0.74), but the piolitazone plus metformin group had lower risk of hypoglycemia (RR=0.39, 95%CI 0.15 to 1.01, P=0.05); when the course of treatment >24 weeks, only one RCT was included, we didn't conduct pool analysis. ConclusionPiolitazone combined with metformin has similar effect to sulphonylurea combined with metformin in controlling blood sugar, but piolitazone combined with metformin has lower incidence of hypoglycemia. Due to limited quality and quantity of the included studies, the above conclusion need to be verified by more high quality studies.

    Release date:2016-10-26 01:44 Export PDF Favorites Scan
  • 三种换药方式在连续性肾脏替代治疗中股静脉置管处的应用

    目的探讨无菌纱布、透明敷贴及无菌纱布联合透明敷贴换药在连续性肾脏替代治疗(CRRT)患者股静脉置管处的应用。 方法回顾性分析2011年10月-2012年10月连续行CRRT股静脉置管的229例患者,分别采用无菌纱布(A组,n=50)、透明敷贴(B组,n=77)及无菌纱布联合透明敷贴(C组,n=102)换药。比较出口部位感染、隧道感染及导管感染等指标。 结果A组患者无论是出口部位感染、隧道感染还是导管感染均高于C组患者,差异均存在统计学意义(P<0.05)。而B组与C组患者相比,仅出口部位感染差异有统计学意义(P<0.05),B组高于C组。A组与B组患者出口部位感染、隧道感染差异有统计学意义(P<0.05),A组均高于B组,导管感染两组差异无统计学意义(P>0.05) 。 结论在股静脉置管处使用无菌纱布联合透明敷贴换药可以显著降低感染率,是一种值得推广应用的方法。

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