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find Keyword "功能残气量" 2 results
  • Experimental research on the effect of functional residual capacity on the deposition of inhalable particles in human alveoli region

    Research on the deposition of inhalable particles in the alveoli of the lungs is important to the causes, development for common respiratory diseases such as emphysema, and even the optimization of clinical treatment and prevention programs of them. In this paper, an in vitro experimental model was established to simulate the deposition of terminal bronchioles and pulmonary acinus particles. The deposition rate of inhalable particles with different particle sizes in the pulmonary acinus was studied under different functional residual capacity. The results showed that the particle diameter was an important factor affecting the deposition of particles in the lung alveoli. Particles with 1 μm diameter had the highest deposition rate. With the functional residual capacity increasing, particulate deposition rate significantly reduced. The results of this study may provide data support and optimization strategy for target inhalation therapy of respiratory diseases such as emphysema and pneumoconiosis. The established model may also provide a feasible in vitro experimental model for studying the deposition of inhalable particles in the pulmonary alveoli.

    Release date:2018-08-23 05:06 Export PDF Favorites Scan
  • 小剂量甲泼尼龙对中重度急性呼吸窘迫综合征患者肺容积及氧合影响的临床分析

    目的探讨小剂量甲泼尼龙对中重度急性呼吸窘迫综合征(ARDS)患者肺容积及氧合的影响。方法收集 2019 年 6 月至 2020 年 6 月锦州医科大学附属第一医院重症医学科收治的 50 例中重度 ARDS 机械通气患者,按照随机数字表法将患者分为甲泼尼龙试验组和常规治疗对照组,观察患者治疗前后的功能残气量(FRC)、氧合指数(PaO2/FiO2)、血清乳酸(cLac)及超敏 C 反应蛋白(hs-CRP)变化及患者预后相关指标;采用 Pearson 法分析 FRC 与 PaO2/FiO2 的相关性。采用受试者工作特征(ROC)曲线评估 FRC 和 PaO2/FiO2 对 ARDS 患者 28 天病死率的预测价值。结果两组患者治疗后第 4、7 天的 FRC、PaO2/FiO2、PaO2、PaCO2、cLac 及 hs-CRP 均较治疗前改善(均 P<0.05),而且试验组在治疗后的第 4、7 天的 FRC、PaO2/FiO2、PaO2 显著高于对照组,cLac、hs-CRP 及 PaCO2 显著低于对照组(均 P<0.05)。试验组呼吸机使用时间、住院时间、28 天病死率等均低于对照组(均 P<0.05)。FRC 与 PaO2/FiO2 存在显著相关性(r=0.731,P<0.05)。ROC 曲线分析显示,FRC 和 PaO2/FiO2 对中重度 ARDS 患者 28 天病死率均有预测价值,其 ROC 曲线下面积分别为 0.841 和 0.802(均 P<0.05)。结论早期应用小剂量甲泼尼龙可以显著改善中重度 ARDS 患者 FRC 和 PaO2/FiO2,降低 28 天病死率,疗效确切、安全性高,并且通过动态监测 FRC 对于中重度 ARDS 患者预后预测具有较好参考价值。

    Release date:2021-06-30 03:41 Export PDF Favorites Scan
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