Objective To analyze the research hotspots and development trend of medical advice at home and abroad, and provide the basis for the research related to medical advice in China. Methods The China National Knowledge Infrastructure and Web of Science were searched from January 1991 to November 2023 to collect domestic and international studies on medical prescriptions. Bibliometrics and CiteSpace software were used for analysis. Results A total of 3 155 articles were included. The number of publications on medical advice reached its peak in 2013, and the trend of domestic and foreign publications was consistent; the institution with the largest number of publications in China was Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology; the top three hotspots of attention in China were rational medication use, intravenous medication dispensing center and nursing care; the top three hotspots of attention in foreign countries were care, impact, and system; the top three hotspots of attention in China were intravenous medication (centralized) dispensing center and medical prescription audit 2 emergent words emergent rate had been continued to date; foreign polst, palliative care and advance care planning 3 emergent words emergent rate had been continued to date; domestic in the past five years, the key words were quality improvement, lean management, transitional care, rationality evaluation, prescription front audit system and medication adherence; the keywords for the last five years in foreign countries were assessmen, risk factor, clincial pathway. ConclusionsDomestic research on medical prescriptions needs to pay more attention to the decision-making of doctors when they give medical prescriptions and the timely monitoring of medication errors, and based on the more mature research on medical prescriptions in foreign countries, domestic research needs to combine the concepts of computer-assisted decision-making and value-based medicine to explore in-depth the correlation between medical prescriptions and the quality of medical care and patient value. It is also needed to combine computer-assisted decision-making and the concept of value-based medicine to explore the intrinsic connection between medical advice and medical quality and patient value.