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find Keyword "华法令" 2 results
  • 心脏机械瓣膜置换术后抗凝治疗的安全性

    目的 探讨心脏机械瓣膜置换术后服用华法令的安全剂量及抗凝期间的注意事项。 方法 回顾性分析1999 年12 月至2010 年10 月皖南医学院附属弋矶山医院132 例行心脏瓣膜置换术后进行华法令抗凝治疗患者的临床资料,其中男73 例,女59 例;年龄27 ~ 78 岁;术后口服华法令抗凝,随访3 个月~ 10 年,分析华法令应用情况及其并发症发生情况。 结果 手术时间(240±96) min,体外循环时间(112±52) min,主动脉阻断时间(81±23) min。全组术后出现皮肤紫癜2 例,死亡2 例。随访117 例,随访率90%(117/130),随访期间月经期月经量过多导致贫血4 例,血尿3 例,反复鼻衄或牙龈出血共4 例,消化道出血1 例,脑出血1 例,下肢栓塞1 例,脑梗死1 例,均治愈或好转。 结论 心脏机械瓣膜置换术后正确服用华法令抗凝治疗,及时监测,注意各种干扰因素可以明显降低并发症的发生率。

    Release date:2016-08-30 05:48 Export PDF Favorites Scan
  • Observation on Therapeutic Effect of Warfarin on 103 Pregnant Women with Prosthetic Mechanical Heart Valves Throughout Pregnancy

    Abstract: Objective To investigate the anticoagulation effect of warfarin on pregnant women with prosthetic mechanical heart valves during the whole course of pregnancy and their fetuses. Methods Followup survey was carried out on 103 pregnant women with prosthetic mechanical heart valves treated in the Second Xiangya Hospital of Central South University from April 1998 to June 2010. Their age ranged from 19 and 38 years (26.4±3.8 years). All the 103 pregnant women were given oral administration of warfarin during the whole course of pregnancy. The average dose of domestic warfarin was 3.30±0.43 mg/d (87 cases), while the average dose of imported warfarin was 2.90±1.05 mg/d (16 cases). Results None of the patients suffered from serious embolic events. One patient suffered from spontaneous peritoneal hemorrhage. There were 4 cases of intrauterine deaths, and 5 cases of fetal malformation including 1 case of Down’s syndrome and 4 cases of hydrocephalus. Six cases of low birth weight infants and 1 case of ABO hemolytic disease were also found. All the other neonates were healthy with normal weight. No pregnant women suffered from postpartum hemorrhage. Conclusion Oral administration of low dose warfarin (lt;5 mg/d) during the whole course of pregnancy is a relative safe and effective anticoagulation protocol.

    Release date:2016-08-30 05:57 Export PDF Favorites Scan
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