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find Keyword "卵巢上皮性癌" 2 results
  • 卵巢上皮性癌脑转移

    卵巢上皮性癌(EOC)是妇科三大恶性肿瘤之一,其死亡率高。卵巢上皮性癌脑转移的发生率较低,但是其预后差,近年EOC的脑转移发生率有增高趋势。脑转移可通过患者的症状、体征、头颅CT、MRI等方法较易诊断。目前缺乏对卵巢上皮性癌脑转移的标准治疗方案。其治疗方法可选择手术、全脑放射治疗(WBRT)、立体定位放射治疗(SRS)、化学疗法,综合多种治疗方法效果优于单一治疗方式。

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  • The efficiency of fertility-sparing surgery in early stage epithelial ovarian cancer: a meta-analysis

    Objective To systematically evaluate the efficiency of fertility-sparing surgery (FSS) compared with radical comprehensive surgery (RCS) in early stage epithelial ovarian cancer (eEOC). Methods We searched databases including PubMed, EMbase, The Cochrane Library (Issue 8, 2016), Web of Knowledge, CBM, WanFang Data and CNKI to collect the studies about FSS compared with RCS for eEOC from ineaption to August 10th, 2016. Two reviewers independently evaluated the eligibility of identified studies and extracted the data. Then, meta-analysis was performed using Stata 12.0 software. Results Eight studies involving 2 561 patients were included. The results of meta-analysis showed that: compared with RCS, the aggregated RR of overall survival (OS) of FSS (univariate analysis: RR=1.03, 95%CI 0.98 to 1.07,P=0.815; multivariate analysis: RR=0.81, 95%CI 0.52 to 1.28,P=0.255), the cumulative disease free survival (DFS) of FSS (univariate analysis: RR=1.02, 95%CI 0.96 to 1.09,P=0.968; multivariate analysis: RR=1.24, 95%CI 0.65 to 2.39,P=0.115) and the recurrence of FSS (RR=0.86, 95%CI 0.57 to 1.30,P=0.902), there was no significant difference. This pattern also emerged in the subgroup analysis for FIGO IA and IC patients, and the results showed that there was no significant difference between FSS and RCS in IA patients (OS: RR=0.99, 95%CI 0.98 to 1.02,P=0.186; DFS: RR=1.01, 95%CI 0.95 to 1.06,P=0.541); and IC patients (OS: RR=0.95, 95%CI 0.86 to 1.04,P=0.251; DFS: RR=0.94, 95%CI 0.80 to 1.11,P=0.664). Conclusion In eEOC, FSS does not have a negative effect on oncological outcomes compared with RCS. However, well-designed and large-scale trials are needed to verify this outcome in the future.

    Release date:2017-04-24 03:30 Export PDF Favorites Scan
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