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find Keyword "原发性" 330 results
  • Influence Factor of Childhood Essential Hypertension: A Meta-Analysis

    Objective To investigate influence factors of childhood essential hypertension and provide scientific evidence for prevention and management of the disease. Methods Relevant studies were searched using PubMed, ISI Web of Knowledge, Ovid, CNKI and VIP from January 2007 to December 2011. STATA 11 was applied for meta-analysis. After heterogeneity analysis, influence factors (OR with 95%CI) were estimated using fixed or random effect models. Sensitivity analyses were used for evaluating the robustness of the results. Publication bias was assessed by Egger’s test and funnel plot. Results A total of 13 studies involving 4 278 cases and 37 230 controls were included. The pooled OR and its 95%CI of different factors associated with hypertension among children were: gender (male) 1.283 (1.063 to 1.549), age 1.013 (0.975 to 1.052), overweight 2.622 (1.985 to 3.464), obesity 3.730 (2.299 to 6.051), waist circumstance 1.060 (1.036 to 1.085), family history 1.189 (0.956 to 1.480), and frequency of physical activities 0.584 (0.460 to 0.742). Conclusion Current results indicate that gender (male), overweight, obesity, waist circumstance are risk factors of hypertension among children, while frequency of physical activities is protective factor.

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  • Carvedilol versus Metoprolol for Primary Hypertension: A Systematic Review

    Objective To systematically review the effectiveness and safety of carvedilol and metoprolol for primary hypertension. Methods Such databases as PubMed, EMbase, Web of Science, The Cochrane Library, CBM, CNKI, VIP and WanFang Data were electronically searched for relevant studies from inception to December, 2012. Two reviewers independently screened literature according to the inclusion and exclusion criteria as well as the methods recommended by the Cochrane Collaboration, extracted data, and assessed the methodological quality of the included studies. Then, meta-analysis was performed using RevMan 5.1 software. Results 7 trials involving 2 243 patients were included. The results of meta-analysis showed no significant difference in the reduction of systolic blood pressure, diastolic blood pressure, and heart rate between the carvedilol and metoprolol groups (Pgt;0.05). However, the carvedilol group was superior to the metoprolol group in improving serum triglyceride (MD=0.75, 95%CI 0.45 to 1.04, Plt;0.000 01), serum cholesterol (MD=0.38, 95%CI 0.19 to 0.56, Plt;0.000 1), serum low density lipoprotein (MD=0.59, 95%CI 0.33 to 0.85, Plt;0.000 01), serum high density lipoprotein (MD= –0.09, 95%CI –0.16 to –0.02, P=0.008), and fasting plasma glucose (MD=0.36, 95%CI 0.21 to 0.51, Plt;0.000 01). In addition, the incidence of drug related adverse reaction was significantly lower in the carvedilol group (OR=0.39, 95%CI 0.24 to 0.63, P=0.000 1). Conclusion Based on current evidence, carvedilol tends to have beneficial effects on metabolic parameters and safety profiles, compared with metoprolol.

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  • Effectiveness and Safety of Implanting Sustained-Release 5-Fluorouracil during Hepatectomy for Primary Liver Cancer: A Systematic Review

    Objective To systematically review the effectiveness and safety of implanting sustained-release 5-fluorouracil during hepatectomy in patients with primary liver cancer (PLC). Methods We electronically searched the following databases including CENTRAL, MEDLINE, EMbase, WanFang Data, CBM, CNKI and VIP to collect randomized controlled trials (RCTs) on the effectiveness and safety of implanting sustained-release 5-fluorouracil during hepatectomy vs. hepatectomy alone for PLC from inception to October, 2012. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data and assessed the quality of the included studies. Then, meta-analysis was performed using RevMan 5.0 software. Results A total of 6 RCTs involving 951 patients were included. The results of meta-analysis showed that, implanting sustained-release 5-fluorouracil during hepatectomy significantly decreased the total recurrence rates of 1-year and 3-year (1 year: RR=0.48, 95%CI 0.36 to 0.65, Plt;0.000 01; 3 years: RR=0.69, 95%CI 0.50 to 0.96, P=0.03). However, the two groups were alike in decreasing the surem levels of AFP. Besides, the commonly-seen adverse reaction of implanting sustained-release 5-fluorouracil during hepatectomy included abdominal pain and bile leakage. Conclusion Implanting sustained-release 5-fluorouracil during hepatectomy can decrease the 1-year and 3-year recurrence rates of PLC patients, especially for HCC at the early stage. But this conclusion should be interpreted with caution and needs more strictly-designed RCTs with large sample size and enough long follow-up to verify.

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  • Traditional Chinese Medicine plus Transcatheter Arterial Chemoembolization for Unresectable Hepatocellular Carcinoma: A Meta-analysis of Randomized Controlled Trials

    Objective To evaluate the effectiveness and safety of traditional Chinese medicine (TCM) plus transcatheter arterial chemoembolization (TACE) compared with TACE alone, in the treatment of unresectable hepatocellular carcinoma (HCC). Methods The Cochrane Library, MEDLINE, EMBASE, CANCERLIT, CBM, CNKI and VIP were searched electronically. Relevant journals and conference proceedings were also handsearched. The quality of included studies was assessed according to the criteria recommended by the Cochrane Handbook for Systematic Reviews of Interventions, and meta-analyses were performed for homogeneous studies using The Cochrane Collaboration’s RevMan 4.2.10 software. Subgroup analyses by frequency of TACE (lt;3 or ≥3 times) were also performed. Results Thirty seven trials, all published in China, involving 2 653 participants were included. The quality of 2 studies was graded B (medium) and that of the other 35 was graded C (low). Meta-analyses showed that TCM plus TACE, compared with TACE alone, could significantly improve survival, tumor response (complete and partial), quality of life and clinical symptoms, and was also associated with a lower incidence of adverse reactions. Subgroup analyses indicated that, patients with less than three TACE had more significant improvement in survival and clinical symptoms, while patients with three or more TACE had more significant improvement in tumor response and quality of life. The incidence of adverse reactions was similar between these two different frequencies of TACE. Conclusions The treatment regimen of TCM plus TACE is superior to TACE alone in patients with unresectable HCC. As the existing data have a high risk of bias, the current evidence is insufficient to define the efficacy of the combination treatment, and further large-scale, high-quality randomized controlled trials are needed.

    Release date:2016-08-25 03:36 Export PDF Favorites Scan
  • Selective Interventional Therapy for Liver Cancer Related Portal Hypertension

    目的 评价选择性介入治疗在原发性肝癌(HCC)门脉高压症中的应用价值。 方法 2008年11月-2011年3月,收治65例临床明确诊断的HCC伴门脉高压症患者,选择性使用肝动脉化学疗法(化疗)栓塞术、脾栓塞术、门静脉化疗栓塞术、门静脉支架、胃冠状静脉栓塞术等介入术式,术后通过观察临床指标、定期复查影像检查等了解病变转归,随访生存期并评价疗效。 结果 65例HCC患者均合并不同程度门静脉高压,其中门静脉癌栓46例中有37例显示肝动脉-门静脉分流,通过肝动脉及门静脉化疗栓塞术进行主瘤体及癌栓治疗。11例行门静脉支架置入术,支架置入后门静脉压较术前明显下降(P<0.01),支架中位通畅时间为5.8个月。39例行胃冠状静脉和(或)胃短静脉栓塞术,术后有4例再次发生门脉高压性出血,再出血率10.26%。18例行脾动脉栓塞术,术后3个月血小板较术前显著升高(P<0.01)。随访术后3、6、12及24个月的生存率分别为90.77%、69.23%、35.38%及13.85%。 结论 选择性联合使用各种介入术式是治疗HCC及其相关性门脉高压症的一种有效方法,可有效预防高危风险,延长患者生存期。

    Release date:2021-06-23 07:35 Export PDF Favorites Scan
  • Relationship between Peripheral Neuropathy and Anti-Ro/La in Patients with Primary Sjögren Syndrome

    目的 探讨原发性干燥综合征周围神经病变的发生与干燥综合征A型/B型抗体(抗SSA/SSB抗体)的关系。 方法 纳入2009年1月-2011年12月期间门诊及住院收治的原发性干燥综合征患者88例。所有患者均接受神经系统检查,采用蛋白质印迹法检测抗SSA抗体和抗SSB抗体,利用全自动化学发光仪检测血清维生素B12水平。 结果 88例原发性干燥综合征患者中有27例(30.7%)存在周围神经病变。有或无周围神经病变的患者在年龄、性别、病程等一般情况方面无明显不同。有周围神经病变和无周围神经病变的原发性干燥综合征患者抗SSA抗体阳性率分别为70.4%(19/27)、70.5%(43/61),差异无统计学意义(χ2=0.000,P=0.991);抗SSA/SSB抗体双阳性率分别为63.0%(17/27)、14.8%(9/61),差异有统计学意义(χ2=17.416,P=0.000);血清维生素B12水平分别为(390 ± 55)、(410 ± 86)pg/dL,差异无统计学意义(t=0.908,P=0.370)。 结论 周围神经病变在原发性干燥综合征患者中较常见,且周围神经病变的发生多伴随血清抗SSA/SSB抗体阳性。

    Release date:2016-08-26 02:09 Export PDF Favorites Scan
  • 原发性肝癌破裂出血的治疗选择

    【摘要】 目的 总结原发性肝癌破裂出血治疗的选择原则。 方法 回顾分析2006年1月-2010年2月收治的 37例原发性肝癌破裂出血患者临床资料。 结果 内科加介入止血效果好,肝叶切除术组术后彻底止血,无手术死亡病例。肝叶切除术9例中生存1年者7例,2年者5例,3年者3例;内科保守治疗19例中生存1年者7例,最长生存16个月;介入治疗组10例中生存1年者4例,2年者1例,无3年以上生存者。 结论 充分评估病情及选择适当的治疗方法对原发性肝癌破裂出血治疗有重要意义。肝叶切除是治疗原发性肝癌破裂出血的有效方法,可明显延长生存期。介入治疗并发症少,急诊肝动脉栓塞止血效果好,可通过血管造影判断有无行根治性手术的可能,以减少不必要的急诊手术探查。

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  • 艾迪注射液联合化疗治疗原发性肝细胞癌系统评价

    目的:评价艾迪注射液配合肝动脉栓塞化疗(Transcatheter arterial chemoembolization TACE)或全身化疗与照单纯TACE或单纯化疗(干预Ⅰ与干预Ⅱ)治疗原发性肝细胞癌的有效性和安全性。方法:采用Cochrane系统评价方法,计算机检索MEDLINE、CENTRAL、EMBASE、CBM、CNKI、VIP和万方数据库、Cochrane图书馆临床对照试验库等;同时互联网检索正在进行的临床试验;手工检索相关期刊和附加检索相关会议论文集。对纳入的同质研究采用RevMan50进行Meta分析。结果:Meta分析结果表明:干预Ⅰ在提高近期疗效有效率、生活质量提高率、减少骨髓抑制率、提高免疫力、提高生存率等方面优于干预Ⅱ,差异有统计学意义。但艾迪注射液联合全身化疗在提高近期疗效有效率方面无统计学意义。结论:艾迪注射液对原发性肝癌有一定的治疗作用,但由于纳入试验的方法学质量普遍较低,期待更多设计合理、严格执行的大样本随机双盲对照试验提供高质量的证据。

    Release date:2016-08-26 02:21 Export PDF Favorites Scan
  • The Clinical Diagnosis and Treatment of the Primary Ureteral Carcinoma

    目的:提高原发性输尿管癌的诊断与治疗水平。方法:回顾性分析20例原发性输尿管癌患者的临床表现、诊断与治疗方法。结果:对中老年人不明原因的单侧腰痛、肾积水、间歇性全程肉眼血尿应考虑该病。术前采用B超、IVU、CT、膀胱镜、逆行尿路造影、MRU检查,确诊为原发性输尿管癌14例,术后病理检查20例均为原发性输尿管移行细胞癌。结论:要提高原发性输尿管癌的术前诊断准确率,需要术前采用多种诊断方法。

    Release date:2016-09-08 10:14 Export PDF Favorites Scan
  • A Preliminary Study on Insulin Resistance and the Familial Clustering Phenomena of Primary Fatty Liver Disease

    目的:对原发性脂肪肝(PFLD)患者及健康对照的一级亲属中PFLD发生情况、胰岛素抵抗(HOMA-IR)指数以及其他相关代谢指标的测定,了解PFLD是否有家族集聚现象及IR在其发病中的可能作用。方法:PFLD的诊断依据B超为脂肪肝并排除继发性原因。PFLD家系组(A组)共42例,11个家庭。选取与A组年龄、性别构成及生活方式和经济状况相近的健康志愿者家系为对照组(B组)共14例,4个家庭。所有受试者均进行身高、体重、腰围、血压等测定,行糖耐量试验、胰岛素及血脂质等检测,并对受试者的生活方式及文化程度和经济状况行量化打分。结果:A组PFLD 33例(78.57%,A1组),无脂肪肝9例(A2组),说明有家族集聚现象。与B组相比,A1组的体重指数、腰围、舒张压、血总胆固醇和HOMA-IR指数显著高于B组(P<0.05);血高密度脂蛋白胆固醇(HDL-C)显著低于B(P<0.05);A2组的各项指标与B组相比差异无统计学意义,但变化趋势呈现出腹型肥胖、IR、代谢紊乱和血压偏高;而A1组及A2组与B组的生活方式及经济状况无明显差异。结论:PFLD具有较强的家族聚发现象,其IR程度显著高于对照组;家族中无脂肪肝者存在IR相关的代谢紊乱趋势。说明某种内在或遗传因素如IR可能与PFLD发病有关。

    Release date:2016-09-08 10:14 Export PDF Favorites Scan
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