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find Author "向圣锦" 2 results
  • Research progress of microglia in hereditary retinal degeneration

    The human hereditary retinal degeneration is one of the main cause of irreversible blindness in the world. the mechanisms leading to retinal photoreceptor degeneration are not entirely clear. However, microglia acting as innate immune monitors are found to be activated early in retinal degeneration in many retinitis pigmentosa animal models. These activated microglia are involved in phagocyte rod cell fragments of degenerated retina, and also produce high levels of cytotoxic substances such as pro-inflammatory cytokines and chemokines, which aggravate the death of adjacent healthy photoreceptor cells. It suggests that microglia activation plays an important role in photoreceptor degeneration. At the same time, a series of studies have confirmed that some drugs can prevent or reduce neuronal death and slow the occurrence and progression of retinal degeneration by interfering with abnormal activation of microglia. It is expected to be a new choice for the treatment of hereditary retinal degeneration.

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  • 老年性黄斑变性的视觉电生理检测

    视觉电生理检查是一种客观的定性的视功能检查法,在老年性黄斑变性(AMD)的早期诊断、病情监测、疗效判定、预后评估中有较好的应用价值。在常规电生理检测方法中, 局部视网膜电图(L-ERG)是较理想的视功能测定法,图形视网膜电图(P-ERG)、图形视 觉诱发电位(P-VEP)也有一定的应用价值。振荡电位可能是新的敏感指标。多焦电生理检测作为新的视功能测定方法,可对AMD患者病变部位的视功能进行定量检测,先于形态学的改 变发现AMD的视功能异常,是AMD早期诊断、病情监测、预后及疗效判断的有价值工具。 (中华眼底病杂志,2004,20:328-330)

    Release date:2016-09-02 05:58 Export PDF Favorites Scan
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