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find Author "吴俊" 12 results
  • Finite Element Analysis of Temperature Field of Retina by Electrical Stimulation with Microelectrode Array

    We studied the influence of electrode array parameters on temperature distribution to the retina during the use of retinal prosthesis in order to avoid thermal damage to retina caused by long-term electrical stimulation. Based on real epiretinal prosthesis, a three-dimensional model of electrical stimulation for retina with 4×4 microelectrode array had been established using the finite element software (COMSOL Multiphysics). The steady-state temperature field of electrical stimulation of the retina was calculated, and the effects of the electrode parameters such as the distance between the electrode contacts, the materials and area of the electrode contact on temperature field were considered. The maximum increase in the retina steady temperature was about 0.004℃ with practical stimulation current. When the distance between the electrode contacts was changed from 130 μm to 520 μm, the temperature was reduced by about 0.006℃. When the contact radius was doubled from 130 μm to 260 μm, the temperature decrease was about 0.005℃. It was shown that there were little temperature changes in the retina with a 4×4 epiretinal microelectrode array, reflecting the safety of electrical stimulation. It was also shown that the maximum temperature in the retina decreased with increasing the distance between the electrode contacts, as well as increasing the area of electrode contact. However, the change of the maximum temperature was very small when the distance became larger than the diameter of electrode contact. There was no significant difference in the effects of temperature increase among the different electrode materials. Rational selection of the distance between the electrode contacts and their area in electrode design can reduce the temperature rise induced by electrical stimulation.

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  • Research advances of tumor-associated macrophages in lung cancer invasion and treatment

    Lung cancer has a high morbidity and mortality, and invasion is one of the major factors that cause recurrence and death in lung cancer patients. Tumor-associated macrophages (TAMs) are cells that have the potential to secrete cytokines, growth hormones, inflammatory substrates, and protein hydrolases, which are associated with the growth, invasion and metastasis of tumors. In this article, we will explore the various chemicals that are manufactured to promote the invasion of lung cancer, as well as the numerous clinical therapeutic features that TAMs possess in the treatment of lung cancer. In addition, we look at the possibility that TAMs might be beneficial in the treatment of lung cancer. We have an innovative investigation of the huge variety of complex substances generated by TAMs, with the goal of determining whether or not the molecules under investigation have the potential to serve as new therapeutic targets. Throughout the whole of the presentation, a significant focus is placed on doing in-depth research to ascertain whether TAMs have the capability to reinforce as viable carriers for unique and creative medications. This not only provides novel concepts for the creation of new targeted therapies but also leads to the development of brand-new, cutting-edge methods for the manufacture of individualized medicines and drug carriers.

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  • Comparison of combined intravenous and topical use of tranexamic acid with different dosage in primary total knee arthroplasty

    Objective To compare the efficacy and safety of intra-articular combined with intravenous administration of tranexamic acid (TXA) with different dosage for reducing blood loss in primary total knee arthroplasty (TKA). Methods Between January 2017 and June 2017, 90 patients suffering from unilateral osteoarthritis who underwent primary TKA were randomly scheduled to three interventions, named groups A, B, and C. Single dosage of TXA via intravenous injection (IV) and different dosages of TXA via intra-articular injection (IA) were utilized in three groups, respectively. All patients in three groups received 1 g TXA IV at 10 minutes preoperatively, and received 1, 2, and 3 g TXA IA diluted in 50 mL saline after wound closure in groups A, B and C, respectively. The age, gender, body mass index, affected side of the knee, grade of osteoarthritis, grade of America Society of Anesthesiologist, preoperative hemoglobin (Hb) concentration, platelet count, preoperative prothrombin time, and activated partial thromboplastin time were not significantly different between groups (P>0.05). The postoperative wound blood drainage, Hb concentration at 1, 3, and 7 days after operation, transfusion rate, and thromboembolic complications were observed. All patients were routinely observed for deep vein thrombosis (DVT) by the color Doppler ultrasonography at 1 week, 1 month, and 3 months after operation, and the symptomatic pulmonary embolism (PE) were observed. Results All patients in three groups were followed up 7-12 months (mean, 8.4 months). There was no significant difference in operation time between groups (P>0.05). The postoperative wound blood drainage was significantly less in groups B and C than that in group A (P<0.05), whereas no significant difference was found between group B and group C (P>0.05). Incision skin necrosis occurred in 1 case of group B and fat liquefaction occurred in 1 case of group C. The other incisions of 3 groups healed by first intention. There was no significant difference in incision complication incidence between groups. The Hb concentration was significantly higher in groups B and C than that in group A at 1, 3, and 7 days after operation (P<0.05). While between group B and group C, the significant difference of Hb concentration only existed at 1 day after operation (P<0.05). The number of patients who got blood transfusion was significantly less in group B (4 cases, 13.3%) and group C (5 cases, 16.7%) than that in group A (9 cases, 30%) (P< 0.05), but no significant difference was found between group B and group C (P>0.05). The result of color Doppler ultrasonography showed that 1 case got DVT in the contralateral calf at 3 weeks in group B. And there was no symptomatic PE in 3 groups. Conclusion Combined administration of IV and IA TXA in a clinically relevant reduction in blood loss was effective and safe in primary TKA, and no thromboembolic complication was observed. The combination of 1 g IV with 2 g IA could be the optional choice.

    Release date:2018-10-31 09:22 Export PDF Favorites Scan
  • 微型接骨板桥式支撑固定治疗骰骨压缩骨折

    目的 总结应用微型接骨板桥式支撑固定治疗骰骨压缩骨折的临床疗效。 方法 2007 年7 月-2009 年11 月,采用指掌骨微型接骨板桥式支撑固定治疗骰骨压缩骨折15 例15 足。男13 例,女2 例;年龄22 ~ 48 岁,平均35 岁。致伤原因:扭伤3 例,交通事故伤2 例,高处坠落伤3 例,重物压伤7 例。合并第4、5 跗跖关节脱位6 例。于伤后2 ~ 10 d,平均3.7 d 行手术切开复位内固定治疗。 结果 术后切口均Ⅰ期愈合。X 线片检查示骨折于术后8 ~ 12周愈合。15 例均获随访,随访时间6 ~ 34 个月,平均19.2 个月。3 例术后8 ~ 12 周开始负重功能锻炼,4 ~ 6 周后X 线片复查示螺钉于钉帽与钉体连接处断裂,未作处理,于术后4.5 ~ 6.0 个月取出内固定。术后4 例持续步行后出现足背外侧胀痛。术后4.5 ~ 6.0 个月取出内固定,内固定取出后4 ~ 6 周根据美国骨科协会足踝外科分会标准评价足功能,获优11 例,良4 例,优良率100%。 结论 指掌骨微型接骨板桥式支撑固定在不进一步损伤关节面的同时既可恢复足外侧柱长度,又可固定骨折及跗跖关节脱位,是治疗骰骨压缩骨折的良好方法之一。

    Release date:2016-09-01 09:03 Export PDF Favorites Scan
  • Perioperative Determination on Function of Blood Coagulation and Activity of Fibrinolysis in Hepatectomy Patients Accompanied with Chronic Hepatic Disease

    【Abstract】ObjectiveTo investigate the changes and significances of the activity of blood coagulation and fibrinolysis in hepatectomy patients accompanied with chronic hepatic disease. MethodsThirtyfive patients who were accompanied with cirrhosis undertook surgery in the second affiliated hospital of Chongqing Medicall University from year 2003 to 2004 were divided into two groups: the first group of 18 cases received hepatectomy and the second group received nonhepatectomy surgical treatment. The (prothrombin time PT), (activated partial thromboplatin time APTT), (thrombin time TT), and the content of (Fibrinogen Fbg) and (Ddimer DD) in the blood drawn from peripheral veins were quantitatively measured by a fullyautomatic chromogenic and immunological assay machine (ACLFutura 9000,USA) at the phases of before operation, right after operation and 24hour after operation, respectively. ResultsAPTT in hepatectomy group increased significantly (P<0.01) and were much higher than the nonhepatectomy group at corresponding phases (P<0.01). PT in hepatectomy group increased even more significantly compared with that of preoperation and right after the operation (P<0.01). The differences of TT at varying phases in hepatectomy group were of no significance (Pgt;0.05). There was also no significant difference of PT, APTT, and TT in nonhepatectomy group at varying phases. ConclusionThe function of blood coagulation is relatively poor and the secondary activity of fibrinolysis is overactivated in hepatectomy patients accompanied with chronic hepatic disease, which indicates a high risk of hemorrhage.

    Release date:2016-09-08 11:52 Export PDF Favorites Scan
  • 单纯第一跖骨基底部闭合性粉碎骨折脱位的治疗

    目的总结手术治疗单纯第1跖骨基底部闭合性粉碎骨折脱位的方法及疗效。 方法2009年2月-2013年10月,采用切开复位微型接骨板跨关节桥式支撑内固定治疗9例(9足)单纯第1跖骨基底部闭合性粉碎骨折脱位。男7例,女2例;年龄22~65岁,平均38.5岁。致伤原因:高处坠落伤6例,扭伤3例。根据Myerson跗跖关节骨折脱位分型,均为B1型。其中3例骨折端骨质压缩。受伤至手术时间2~4 d,平均2.7 d。 结果术后切口均Ⅰ期愈合。患者均获随访,随访时间1年1个月~3年,平均1年8个月。骨折均愈合,愈合时间10~12周,平均10.8周。术后5例固定接骨板靠近关节侧的螺钉断裂,未作特殊处理;9例均于术后6个月~2年取出内固定物。末次随访时,按照美国矫形足踝协会(AOFAS)标准评分为80~95分,平均88.4分。 结论微型接骨板跨关节桥式支撑内固定具有手术操作简便、固定牢固、减少关节面损伤、断钉易取出等优点,是治疗第1跖骨基底部闭合性粉碎骨折脱位理想方法之一。

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  • CLASSIFICATION OF ADULT CUBOID FRACTURE AND EFFECTIVENESS ANALYSIS

    ObjectiveTo study the classification criteria of adult cuboid fracture and its guidance feasibility and effect of treatment. MethodsA retrospective analysis was made on the clinical data of 415 adult patients (416 feet) with cuboid fractures who had complete CT data treated between May 2009 and April 2014. There were 337 males and 78 females, aged 19 to 64 years (mean, 38.8 years). The left foot, right foot, and bilateral feet were involved in 220 cases, 194 cases, and 1 case respectively. The causes of injury were sprain in 106 cases, traffic accident in 65 cases, falling from height in 129 cases, and heavy crushing in 115 cases. The interval of injury and hospitalization was 2 hours to 3 days (mean, 8.5 hours). Based on CT findings, the classification criteria of cuboid fracture was proposed and methods of treatment was statistically analyzed. The external fixation surgery was performed in patients of type I (285 feet), type IIa (18 feet), and type III (5 feet); open reduction and internal fixation were performed in patients of type IIb (41 feet) and type III (67 feet), and bone grafting was used to repair defects in 58 feet (type III). ResultsAll patients were followed up 1 year to 5 years and 11 months (mean, 2 years and 3 months). Primary healing of incision was obtained. In patients with type I fracture, fracture healed in 165 feet at 4-6 weeks (mean, 5.5 weeks), fracture did not heal in the other 120 feet; the American Orthopaedic Foot and Ankle Society (AOFAS) score was 95-100(mean, 96.7) at last follow-up. In patients with type II fracture, fracture healed in all feet at 6-8 weeks (mean, 6.5 weeks); the AOFAS score was 92-100(mean, 95.5) at last follow-up. In patients with type III fracture, malunion was observed at 6-8 weeks in 5 feet undergoing external fixation, and in 9 feet undergoing open reduction and internal fixation with foot lateral column shortening, forefoot abduction deformity, osteoarthritis, lateral foot pain; fracture healed at 8-12 weeks in 58 feet undergoing open reduction and internal fixation, without osteoarthritis, cuboid bone shortening, and pain at cuboid bone; and AOFAS score was 75-97(mean,93.5) at last follow-up. ConclusionThe classification criteria of cuboid fracture proposed based on CT examination is feasible and has guiding significance to the choice of treatment method.

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  • Protective effects of abdominal paracentesis drainage in patients with severe acute pancreatitis-associated liver injury: a historical cohort study

    ObjectiveTo explore the protective effects of abdominal paracentesis drainage (APD) on pancreatitis-associated liver injury in the early phase of severe acute pancreatitis (SAP). MethodsOne hundred and fourteen consecutive patients with SAP, admitted to the General Hospital of Western Theater Command from January 2015 to January 2021, were included in this retrospective study. The patients were divided into the APD group (n=61) and the non-APD group (n=53) based on whether they underwent APD treatment within 72 h of admission. The variables including baseline data, liverfunction tests, inflammation indexes, severity scores and other variables of the two groups were statistically analyzed. ResultsThe hospital mortality in the APD group was lower than that in the non-APD group (8.2% vs. 22.6%, P=0.031). These severity scores (including APACHE Ⅱ score, Ranson score and modified Marshall score) and inflammation indexes (including C-reactive protein, interleukin-6, interleukin-1 and tumor necrosis factor-α) in the APD group were all lower than those in the non-APD group (P<0.05). In terms of liver function related indexes, the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptidase (GGT), total bilirubin (TBIL), and direct bilirubin (DBIL) after treatment in both two groups were significantly lower than those before treatment (P<0.05). The levels of ALT, AST, TBIL and DBIL after treatment in the APD group were lower than those in the non-APD group (P<0.05), and the levels of prealbumin and albumin after treatment in the APD group were higher than those in the non-APD group (P<0.05), but there were no significant differences in the levels of alkaline phosphatase, GGT and 5′ -nucleotidase after treatment in the two group (P>0.05). ConclusionFor SAP patients with ascitic fluid, application of APD can attenuate liver injury and improve liver function in the early stage of SAP.

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  • Research progress on the pathogenesis of chronic obstructive pulmonary disease complicated with lung cancer

    [Abstract]Chronic obstructive pulmonary disease (COPD) occurs mostly in middle-aged and elderly people, and patients often have poor quality of life and can also induce a variety of other lung diseases. At the same time, the lung cancer with the highest morbidity and mortality in the world, has claimed the lives of countless patients. Since the incidence of lung cancer is much higher in patients with COPD than in the general population, there are many links between the two diseases that need to be studied and explored. Although many studies have explored the association between the two, there are few studies on the molecular level of them. This review will focuse on the latest research progress of the pathogenesis of COPD complicated with lung cancer from four aspects: the role of chronic inflammation, programmed cell death, gene and molecular role and lung microbiome imbalance, so as to provide a new reference for the prevention, diagnosis and treatment of COPD complicated with lung cancer.

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  • 18F-FDG PET/CT combined with CT three-dimensional reconstruction in the differentiation of benign and malignant pulmonary nodules: A retrospective cohort study

    Objective To investigate the accuracy of 18F-FDG positron emission tomography/computed tomography (PET/CT) combined with CT three-dimensional reconstruction (CT-3D) in the differential diagnosis of benign and malignant pulmonary nodules. Methods The clinical data of patients who underwent pulmonary nodule surgery in the Department of Thoracic Surgery, Northern Jiangsu People's Hospital from July 2020 to August 2021 were retrospectively analyzed. The preoperative 18F-FDG PET/CT and chest enhanced CT-3D and other imaging data were extracted. The parameters with diagnostic significance were screened by the area under the receiver operating characteristic (ROC) curve (AUC). Three prediction models, including PET/CT prediction model (MOD PET), CT-3D prediction model (MOD CT-3D), and PET/CT combined CT-3D prediction model (MOD combination), were established through binary logistic regression, and the diagnostic performance of the models were validated by ROC curve. Results A total of 125 patients were enrolled, including 57 males and 68 females, with an average age of 61.16±8.57 years. There were 46 patients with benign nodules, and 79 patients with malignant nodules. A total of 2 PET/CT parameters and 5 CT-3D parameters were extracted. Two PET/CT parameters, SUVmax≥1.5 (AUC=0.688) and abnormal uptake of hilar/mediastinal lymph node metabolism (AUC=0.671), were included in the regression model. Among the CT-3D parameters, CT value histogram peaks (AUC=0.694) and CT-3D morphology (AUC=0.652) were included in the regression model. Finally, the AUC of the MOD PET was verified to be 0.738 [95%CI (0.651, 0.824)], the sensitivity was 74.7%, and the specificity was 60.9%; the AUC of the MOD CT-3D was 0.762 [95%CI (0.677, 0.848)], the sensitivity was 51.9%, and the specificity was 87.0%; the AUC of the MOD combination was 0.857 [95%CI (0.789, 0.925)], the sensitivity was 77.2%, the specificity was 82.6%, and the differences were statistically significant (P<0.001). Conclusion 18F-FDG PET/CT combined with CT-3D can improve the diagnostic performance of pulmonary nodules, and its specificity and sensitivity are better than those of single imaging diagnosis method. The combined prediction model is of great significance for the selection of surgical timing and surgical methods for pulmonary nodules, and provides a theoretical basis for the application of artificial intelligence in the pulmonary nodule diagnosis.

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