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find Author "吴燕" 4 results
  • 某重症医学科暴发流行肺结核同比对照分析

    目的 探讨某重症医学科暴发流行肺结核的原因及预防措施。方法 对某重症医学科进行流行病学调查及回顾性分析; 同时与肺结核的高危科室———感染科和呼吸内科进行同比对照研究。结果 本次暴发流行的肺结核患病率为22. 6% , 其中传染性肺结核患病率为12. 9% 。结论 规范结核病收治制度, 完善职业安全防护措施, 加强督导管理。

    Release date:2016-09-13 04:07 Export PDF Favorites Scan
  • Effects of proteasome inhibitor MG132 nuclear factorkappa B pathway and retinal ganglion cells apoptosis in rats with diabetic retinopathy

    Objective To observe the degradation regulation of ubiquitinproteasome inhibitor nuclear factor kappa;B(NF-kappa;B)and its inhibitory signal protein Ikappa;B kinase in earlier period diabetic retinopathy(DR),and the effects on retinal ganglion cells (RGC) apoptosis.Methods Forty healthy adult Wistar rats were randomly divided into control (group A),DR(group B),DR+lowconcentration MG132 treated (group C)and DR+high concentration MG132 treated(group D)groups,10 rats in each group.After 6 and 8 weeks,the results of body masses and fasting blood glucose (FBG) were detected,the expression of NF-kappa;B and Ikappa;B were observed by immunohistochemistry respectively.RGC apoptosis was assessed by the terminal deoxynucleotidyl transferase mediated dUTP-biotin nick-end labelling (TUNEL) method.Results The expression of NF-kappa;B was upregulated in group B compared with group A,its expression decreased in group D compared with group B; but the expression of Ikappa;B was contrary to NF-kappa;B; RGC apoptosis was followed a similar pattern with the expression of NF-kappa;B; the differences among them were statistically significant (P<0.01).Compared the expression of NF-kappa;B,Ikappa;B and RGC apoptosis in group C and D, there were no statistically significant differences(P>0.05).Conclusion Ubiquitin-proteasome inhibitor MG132 can block the activation of NF-kappa;B,inhibit ubiquitination of Ikappa;B degradation and RGC apoptosis.

    Release date:2016-09-02 05:40 Export PDF Favorites Scan
  • Etiology and Clinical Characteristics of 1298 Patients with Spontaneous Intracerebral Hemorrhage

    Objective To investigate the etiological and clinical characteristics of 1298 cases with spontaneous intracerebral hemorrhage. Methods A retrospective analysis was conducted to investigate the epidemiology and clinical characteristics of 1298 patients who suffered from spontaneous intracerebral hemorrhage and were hospitalized in Neurology Dept. of Anhui Provincial Hospital from 2005 to 2009. Results Among 1 298 patients, 822 (63.33%) were male while 476 (36.67%) were female. The constituent ratio of male and female patients was significantly different; the patients mainly suffered from spontaneous intracerebral hemorrhage in winter and spring which was commonly caused by hypertension accounting for 65.87% and was mostly happened on basal ganglia site (n=895, 68.95%). Conclusions The incidence of spontaneous cerebral hemorrhage is related with age, season and hypertension, it is very important to be prevented effectively and to well control the blood pressure.

    Release date:2016-09-07 11:09 Export PDF Favorites Scan
  • Association of Apolipoprotein E Polymorphism and Alzheimer’s Disease in Chinese Population: A Meta-analysis

    Objective To evaluate the relationship between genetic polymorphism of ApoE and Alzheimer’s disease in Chinese population. Methods Such databases as PubMed, EBSCO, CNKI, CBM, and WangFang Data were searched from their establishment to December 2010 to collect the literature about the relationship between genetic polymorphism of ApoE and Alzheimer’s disease in Chinese population. RevMan 5.0 was adopted to conduct consistency check and data merging, and to evaluate publication bias. Results ApoEε4 was the risky allele (Plt;0.05) in Chinese population, and its pooled odds ratios and 95%CI was 3.53 (2.49 to 5.00). ApoEε3 was the protective alleles (Plt;0.05) in Chinese population, and its pooled odds ratios and 95%CI was 0.52 (0.40 to 0.68). ApoEε4/ε4, ApoEε4/ε3, and ApoEε4/ε2 were the risky genotypes (all Plt;0.05) in Chinese population, and their pooled odds ratios and 95%CI were 10.17 (4.25 to 24.19), 2.57 (2.04 to 3.25), and 1.94 (1.13 to 3.34), respectively. ApoEε3/ε3 was the protective genotype (Plt;0.05) in Chinese population, and its pooled odds ratios and 95%CI was 0.67 (0.57 to 0.77). Conclusion In Chinese population, some ApoE alleles and genotypes are associated with Alzheimer’s disease.

    Release date:2016-09-07 11:03 Export PDF Favorites Scan
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