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find Author "吴艳" 6 results
  • 噻唑烷二酮类药物治疗糖尿病肾病的可能机制探讨

    【摘要】噻唑烷二酮类(TZD)药物为有效的核转录因子过氧化酶增殖体活化受体γ的高选择性激动剂,具有非常广泛的作用,除了降低血糖、改善胰岛素抵抗外,还具有胰岛素增敏之外的作用如降低炎性因子的产生、减轻炎症反应和氧化应激、改善血流动力学、降低尿蛋白的排泄等。现仅就TZD对糖尿病肾病的直接肾保护作用及机制进行综述。

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  • The Application of Marketing Service Theory in the Construction of Physical Examination Information System in Massive Comprehensive Hospitals

    目的 探讨营销服务理论(8P)在体检信息系统建设中的应用与实践效果。 方法 借鉴8P理论与理念,以现代信息技术为手段,设计和构建以客户为中心的体检信息系统。 结果 体检信息系统的建立,优化了体检流程,提高了服务效率和报告质量,增加了客户满意度,取得良好的经济和社会效益,为健康体检工作的数字化、规范化管理奠定了良好的基础。 结论 加强体检中心的信息化系统建设,能全面提升中心的工作效率和服务质量,增强市场竞争力。

    Release date:2016-09-08 09:13 Export PDF Favorites Scan
  • 早期慢性阻塞性肺疾病影像学表型的定量评估研究进展

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  • Research progress of non-pharmacological intervention therapy for mild cognitive impairment

    Due to the aging population intensifies, the number of people suffering from mild cognitive impairment (MCI) or dementia is expected to increase, which may lead to a series of public health and social health problems. In the absence of drugs to prevent the transformation of MCI into dementia, it is urgent to find effective non-pharmacological therapies to delay the progress of cognitive impairment. This article will review the diagnosis of MCI and the research progress of non-pharmacological therapies, focusing on the non-pharmacological therapies related to MCI in recent years, including exercise intervention, cognitive intervention, physical and mental exercise, dietary intervention, electroacupuncture, repeated transcranial magnetic stimulation, and multi-component intervention, in order to provide an effective treatment for preventing or delaying the progression of MCI to dementia.

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  • A study on the level of gastrin in patients with type 2 diabetes mellitus and gastroesophageal reflux disease

    Objective To investigate the gastrin level in patients with type 2 diabetes mellitus (T2DM) with gastroesophageal reflux disease (GERD), and analyze the possible mechanism of gastrin in the pathogenesis of T2DM combined with GERD. Methods Thirty-eight patients with T2DM combined with GERD treated between January 2013 and January 2015 were designated as group A; 40 patients with T2DM only were regarded as group B; 36 patients with GERD only were regarded as group C; and another 40 healthy volunteers who underwent physical examination at the same period were regarded as group D. The fasting serum levels of gastrin were measured and compared among the above four groups. Results The fasting serum level of gastrin was significantly higher in group A [(116.53±22.02) pg/mL] than group B [(101.89±20.76) pg/mL], group C [(90.04±21.16) pg/mL], and group D [(92.48±19.69) pg/mL] (P<0.01). The fasting serum level of gastrin in group B was significantly higher than group C and D (P<0.05). There was no significant difference between group C and D in terms of fasting serum level of gastrin (P>0.05). Conclusions There is a high level of gastrin in patients with GERD combined with T2DM. Abnormal secretion of gastrin may be closely related with the occurrence and development of T2DM and GERD.

    Release date:2017-03-27 11:42 Export PDF Favorites Scan
  • Treatment experience of patients with chronic thromboembolic pulmonary hypertension combined with severe right heart dysfunction: A case control study

    Objective To discuss the safety and validity of pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) patients with severe right heart failure (RHF). Methods PEA procedures were performed on 36 patients in Fu Wai Hospital from January 2015 to April 2016. There were 28 males and 8 females, with a mean age of 46.56±11.85 years. According to the New York Heart Association (NYHA) cardiac function classification, 36 patients were divided into preoperative severe RHF group (grade Ⅲ-Ⅳ,n=28) and preoperative without severe RHF group (grade Ⅱ,n=8). Hemodynamic parameters before and after PEA were recorded and 3-18 months' follow-up was done. Results All the patients having PEA surgeries had an obvious decrease of mean pulmonary arterial pressure (from 49.53±13.14 mm Hg to 23.58±10.79 mm Hg) and pulmonary vascular resistance (from 788.46±354.60 dyn·s/cm5 to 352.89±363.49 dyn·s/cm5, bothP<0.001). There was no in-hospital mortality among all the patients. Persistent pulmonary hypertension occurred in 2 patients, perfused lung in 2 patients, pericardial effusion in 2 patients. No mortality was found during the follow-up period. All patients improved to NYHA grade Ⅰ-Ⅱ (WHO grade Ⅰ-Ⅱ), and only 2 patients remained in the NYHA grade Ⅲ (P<0.01). Conclusion The CTEPH patients having PEA surgeries had an obvious improvement in both their hemodynamics results and postoperative heart function, which in return could improve their quality of life.

    Release date:2017-04-01 08:56 Export PDF Favorites Scan
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