Objective To explore the causal association between obstructive sleep apnea (OSA) and venous thromboembolism (VTE). Methods Using the summary statistical data from the FinnGen biological sample library and IEU OpenGWAS database, the relationship between OSA and VTE, including deep vein thrombosis (DVT) and pulmonary embolism, was explored through Mendelian randomization (MR) method, with inverse variance weighted (IVW) as the main analysis method. Results The results of univariate MR analysis using IVW method showed that OSA was associated with VTE and pulmonary embolism (P<0.05), with odds ratios and 95% confidence intervals of 1.204 (1.067, 1.351) and 1.352 (1.179, 1.544), respectively. There was no correlation with DVT (P>0.05). Multivariate MR analysis showed that after adjustment for confounding factors (smoking, diabetes, obesity and cancer), OSA was associated with VTE, DVT and pulmonary embolism (P<0.05), with odds ratios and 95% confidence intervals of 1.168 (1.053, 1.322), 1.247 (1.064, 1.491) and 1.158 (1.021, 1.326), respectively. Conclusion OSA increases the risk of VTE, DVT, and pulmonary embolism.
目的 探讨腹腔镜联合胆道镜保胆取石术的临床价值。方法 回顾性分析我院2009年2月至2010年2月期间95例腹腔镜联合胆道镜保胆取石术患者的临床资料。结果 95例患者均顺利完成保胆取石术，平均手术时间49 min，术中平均出血量9 ml，除8例发生切口脂肪液化外无其他手术并发症发生，1年内随访无复发。结论 在严格掌握适应证的前提下，对胆囊结石患者有选择性地采用腹腔镜联合胆道镜保胆取石术，是一种可供选择的安全的微创治疗方法。