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find Author "周斌" 17 results
  • 异位胰腺3例报告

    病例1女,48岁。行胆囊切除时发现胃前壁大弯侧有淡黄色块状物镶嵌于胃壁上,直径约4 cm,遂行胆囊切除并将胃壁肿块连同周围5 cm范围胃壁切除。切除标本见肿块呈分叶状,浅黄色,位于粘膜下及肌层。术后病理诊断: 胃异位胰腺。病例2男,29岁。上腹部疼痛6年伴呕血、黑便2天入院。X线钡餐诊断为十二指肠球部溃疡。入院时查体: P 120次/分,BP 10.0/8.0 kPa,Hb 50 g/L,白细胞15.6×109/L,中性粒细胞0.76,淋巴细胞0.24。经紧急处理未能止住出血,急诊行剖腹探查。于十二指肠球部扪及3 cm×3 cm×1 cm大胼胝溃疡,行毕Ⅱ式胃大部切除。见切除之标本溃疡形成部肠壁有一2 cm×1 cm×1 cm大实质肿块,红黄色,中心液化坏死与肠腔相通,并可见直径约2 mm的小动脉断端。术后病理报告: 十二指肠球部异位胰腺并溃疡形成。病例3男,42岁。进行性上腹胀痛、呕吐2个月,扪及包块1个月入院。经对症处理后剖腹探查,见十二指肠空肠曲部肠壁有8 cm×6 cm×6 cm大包块,与周围分界不清,肠腔狭窄。因浸润范围较广且包裹结肠中动脉和腹腔动脉干,遂行胃空肠吻合,并取肿块组织送检后关腹。术后病理报告: 空肠异位

    Release date:2016-08-28 05:10 Export PDF Favorites Scan
  • Research Progress of a Novel Pro-apoptosis Gene PNAS-4 in Gene Therapy and Its Molecular Mechanism Hypotheses

    PNAS-4 is a novel pro-apoptosis gene identified latetly. In recent years, there has been a large number of research reports on the basic studies about PNAS-4 in cancer gene therapy and gene therapy of PNAS-4 alone or combined with chemotherapy or radiotherapy manifested a good application prospect, but its molecular mechanisms to promote apoptosis is not clear yet. In this paper, recent research about PNAS-4 in cancer gene therapy is briefly reviewed, and recent hypotheses on its molecular mechanisms to promote apoptosis are especially elucidated. Based on its newly identified characteristics of structural domain, we made a point that PNAS-4 might regulate functions of some target protein related to apoptosis by deSumoylation as a new deSumoylating isopeptidase, and consequently promote apoptosis.

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  • Experimental Study on Effects of Endothelin and Xuesaitong Injection on Hepatic, Renal and Myocardial Tissues in Obstructive Jaundice

    【Abstract】ObjectiveTo study the effects of endothelin (ET) and Xuesaitong injection on hepatic, renal and myocardial tissues after bile duct ligation (BDL) in rabbits. MethodsSeventytwo rabbits were randomly divided into three groups: BDL group (24 rabbits), BDL+Xuesaitong injection group (24 rabbits), and sham operation group (24 rabbits). Each group was subdivided into four subgroups of postoperative 3, 6, 9 and 12 d (6 rabbits in each subgroup). Automatic biochemical analysis equipment was used to detect the levels of serum TBIL, ALT, BUN and Crea. The levels of ET in plasma, hepatic, renal and myocardial tissues were measured with radioimmunological method. ResultsThe levels of ET in plasma, hepatic, renal and myocardial tissues in both BDL group and BDL+Xuesaitong injection group were higher than those of sham operation group (P<0.01). The levels of ET in plasma and tissues of BDL+Xuesaitong group were lower than those in BDL group (P<0.05). ConclusionObstructive jaundice can lead to an increase of ET in plasma, hepatic, renal and myocardial tissues, the level of ET increases with the time of obstruction. Xuesaitong injection may play a protective role in the injury of hepatic, renal and myocardial tissues after obstruction by decreasing the level of ET in plasma and tissues.

    Release date:2016-08-28 04:20 Export PDF Favorites Scan
  • Potential Therapeutic Effect of Paracrine Factors from Bone Marrow-derived Mesenchyme Stem Cells in the Treatment of Severe Acute Pancreatitis

    Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is one of the most popular therapeutic measures in severe acute pancreatitis (SAP). However, technical challenges and ethical concern have hindered its clinical application. Paracrine factor, as a new safe and easy handing therapeutic measure, can work comparably effective as BMSC transplantation in SAP therapy, but bio-safe risks could be greatly reduced. In this paper, we reviewed the therapeutic effect and potential mechanism of paracrine factors in the treatment of SAP. The injection of paracrine factors yielded from cultured cell suspension will be a new cell therapeutic measure for SAP.

    Release date:2021-06-24 10:16 Export PDF Favorites Scan
  • C臂X线机引导下双Endobutton钢板微创治疗肩锁关节脱位

    目的总结C臂X线机引导下双Endobutton钢板微创治疗RockwoodⅢ型及以上肩锁关节脱位的疗效。 方法2010年1月-2012年6月,于C臂X线机引导下采用双Endobutton钢板微创治疗肩锁关节脱位21例。男16例,女5例;年龄19~46岁,平均29.8岁。致伤原因:摔伤14例,交通事故伤7例。损伤至手术时间为5~12 d,平均8.3 d。根据Rockwood分型标准:Ⅲ型14例,Ⅳ型5例,Ⅴ型2例。术前肩关节疼痛视觉模拟评分(VAS)为(7.82±0.21)分,Constant评分为(35.3±4.6)分。 结果术后切口均Ⅰ期愈合,无神经、血管损伤等手术相关并发症发生。患者均获随访,随访时间12~14个月,平均13.4个月。X线片复查示,锁骨远端高度均达到解剖复位。术后1周及1、12个月Constant评分分别为(85.2±5.6)、(90.1±3.5)、(96.3±2.8)分;活动状态下VAS评分分别为(4.33±0.34)、(2.12±0.26)、(0.85±0.16)分;术后各时间点以上两指标均较术前显著改善(P<0.05)。 结论C臂X线机引导下双Endobutton钢板微创治疗Rockwood Ⅲ型及以上肩锁关节脱位安全、有效。

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  • Effect of comprehensive measures based on nosocomial infection management system on improving reporting and follow-up of occupational exposure among medical staff

    ObjectiveTo enhance the management of occupational exposure, improve post-exposure reporting, promote post-exposure follow-up, reduce blood-borne infections caused by exposure, and ensure occupational safety among medical staff by using comprehensive measures based on nosocomial infection management system.MethodsAll the reported cases of occupational exposure were retrospectively collected from August 2012 to July 2018. The cases were divided into the control group (from August 2012 to July 2015) in which the data were reported in paper, and the observation group (from August 2015 to July 2018) in which the data were reported by nosocomial infection management system. The report and follow up results of occupational exposure in the two groups were compared and analyzed.ResultsAfter three years application of nosocomial infection management system, the occupational exposure report increased 95.8% (increased from 16.7 cases per year to 32.7 cases per year); the follow-up ratio of occupational exposure after one month,3 months and 6 months increased from 65.0% to 93.3% (χ2=15.184, P<0.001), 45.0% to 73.3% (χ2=9.033, P=0.003), and 25.0% to 53.3% (χ2=8.522, P=0.004), respectively.ConclusionApplication of nosocomial infection management system can increase the report of occupational exposure and the follow-up ratio of occupational exposure significantly.

    Release date:2019-08-15 01:20 Export PDF Favorites Scan
  • Single-Tube Polymerase Chain Reaction Amplification Protocol for SequencingBased Typing of Human Leukocyte Antigen DRB1

    【Abstract】ObjectiveTo develop a new singletube polymerase chain reaction amplification (ST Amp) protocol for the efficient sequencing-based typing (SBT) of human leukocyte antigen DRB1(HLA-DRB1).MethodsA set of 7 group-specific exonic 5′ amplification primers and a single generic 3′ primer were included together in a single PCR mix to facilitate a single PCR amplification per sample for HLA-DRB1 typing.ResultsAll samples were successfully typed, the typing result was accurate and repeatable.ConclusionST Amp technique has resulted in the ability to perform high-resolution, high-specificity and high-throughput HLA-DRB1 typing by DNA sequencing.

    Release date:2016-09-08 11:54 Export PDF Favorites Scan
  • Effect of ECRS management mode on nosocomial infection prevention and control quality of multidrug-resistant organisms

    Objective To evaluate the effect of ECRS management model on the quality of prevention and control of hospital infection with multidrug-resistant organisms (MDROs). Methods The data related to the prevention and control of MDROs in the First Hospital of Nanchang in 2020 and 2021 were retrospectively collected. The hospital implemented routine MDRO infection prevention and control management in accordance with the Expert Consensus on the Prevention and Control of Multi-drug Resistant Bacteria Nosocomial Infection in 2020. On this basis, the hospital applied the four principles of the ECRS method to cancel, combine, rearrange and simplify the MDRO infection prevention and control management. The detection rate of MDROs on object surfaces, the incidence rate of hospital infection of MDROs, the compliance rate of hand hygiene, the implementation rate of contact isolation prevention and control measures, and the pass rate of MDRO infection prevention and control education assessment were analyzed and compared between the two years. Results The detection rate of MDROs on the surfaces in 2021 was lower than that in 2020 (9.39% vs. 31.63%). The hospital-acquired MDRO infection rate in 2021 was lower than that in 2020 (1.18% vs. 1.46%). The hand hygiene compliance rates of medical staff, workers and caregivers in 2021 were higher than those in 2020 (90.99% vs. 78.63%, 73.51% vs. 45.96%, 70.96% vs. 33.71%). The implementation rate of contact isolation prevention and control measures in 2021 was higher than that in 2020 (93.31% vs. 70.79%). The qualified rates of MDRO infection prevention and control education in medical personnel, workers and caregivers in 2021 were higher than those in 2020 (96.57% vs. 81.31%, 76.47% vs. 47.95%, 73.17% vs. 34.19%). All the differences above were statistically significant (P<0.05). Conclusion ECRS management mode can improve the execution and prevention level of MDRO hospital infection prevention and control, and reduce the incidence of MDRO hospital infection.

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  • Factors influencing pulmonary complications after liver transplantation and the construction of a predictive model

    Objective To investigate the factors influencing the occurrence of postoperative pulmonary complications (PPCs) in liver transplant recipients and to construct Nomogram model to identify high-risk patients. Methods The clinical data of 189 recipients who underwent liver transplantation at the General Hospital of Eastern Theater Command from November 1, 2019 to November 1, 2022 were retrospective collected, and divided into PPCs group (n=61) and non-PPCs group (n=128) based on the occurrence of PPCs. Univariate and multivariate logistic regression analyses were used to determine the risk factors for PPCs, and the predictive effect of the Nomogram model was evaluated by receiver operator characteristic curve (ROC) and calibration curve. Results Sixty-one of 189 liver transplant patients developed PPCs, with an incidence of 32.28%. Univariate analysis results showed that PPCs were significantly associated with age, smoking, Child-Pugh score, combined chronic obstructive pulmonary disease (COPD), combined diabetes mellitus, prognostic nutritional index (PNI), time to surgery, amount of bleeding during surgery, and whether or not to diuretic intraoperatively (P<0.05). Multivariate logistic regression analysis showed that age [OR=1.092, 95%CI (1.034, 1.153), P=0.002], Child-Pugh score [OR=1.575, 95%CI (1.215, 2.041), P=0.001], combined COPD [OR=4.578, 95%CI (1.832, 11.442), P=0.001], combined diabetes mellitus [OR=2.548, 95%CI (1.024, 6.342), P=0.044], preoperative platelet count (PLT) [OR=1.076, 95%CI (1.017, 1.138), P=0.011], and operative time [OR=1.061, 95%CI (1.012, 1.113), P=0.014] were independent risk factors for PPCs. The prediction model for PPCs which constructed by using the above six independent risk factors in Nomogram had an area under the ROC curve of 0.806. Hosmer and Lemeshow goodness of fit test (P=0.129), calibration curve, and decision curve analysis showed good agreement with Nomogram model. Conclusion The Nomogram model constructed based on age, Child-Pugh score, combined COPD, combined diabetes mellitus, preoperative PLT, and time of surgery can better identify patients at high risk of developing PPCs after liver transplantation.

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  • Diagnosis and Treatment of Acute Abdominal Pain Caused by Hepatic Hydatid (Reports of 297 Cases)

    Objective To summarize the experience of diagnosis and treatment of acute abdominal pain caused by hepatic hydatid. Methods The preoperative diagnosis, the surgical methods and the curative effect after operation of 297 patients with acute abdominal pain caused by hepatic hydatid who were treated in our hospital from 1960 to 2004 were analyzed. Results The healing rate was 95.96% (285/297 cases), and the death rate was 4.04% (12 /297 cases). Six out of 12 cases of death were caused by diffusive biliary peritonitis and allergic shock attributable to the rapture of hydatid into abdominal cavity. Two patients died of malnutrition caused by the spreading of Echinococcus and the correspondingly repeated operations. Another 4 patients with giant hydatid containing 7 000-12 000 ml fluid, died of hepatic insufficiency caused by the postoperative infection in the cyst. Conclusion The acute abdominal pain caused by hepatic hydatid should be treated mainly through emergency operation and the necessary antianaphylaxis, anti-infection and antishock therapies should also be used at the same time.

    Release date:2016-08-28 04:08 Export PDF Favorites Scan
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