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find Author "周明阳" 3 results
  • Effects of 11,12-epoxyeicosatrienoic acid on reperfusion arrhythmias in the immature rabbit hearts

    Objective To improve the myocardial protection result, observe the effects of 11,12 epoxyeicosatrienoic acid (11,12 EET) on reperfusion arrhythmias in the isolated perfused immature rabbit hearts, which underwent long term preservation. Methods Sixteen isolated rabbit hearts were randomly assigned to two groups, 8 rabbits each group. Control group: treated with St.Thomas Ⅱ solution, experimental group: treated with St.Thomas Ⅱ solution plus 11,12 EET. By means of the Langendorff technique, these isolated rabbit hearts were arrested and stored for 16 hours with 4℃ hypothermia, and underwent 30 minutes of reperfusion(37℃). The mean times until the cessation of both electrical and mechanical activity were measured after infusion of cardioplegia. The heart rate (HR), coronary flow (CF), myocardial water content (MWC), value of creatine kinase (CK) and lactic dehydrogenase (LDH), myocardial calcium content and the arrhythmias score (AS) during the period and at the endpoint of the reperfusion were observed. Results The times until electrical and mechanical activity arrest in the experimental group were significantly shorter than those in control group ; HR, CF, MWC, CK, LDH, myocardial calcium content and AS were significantly better than those in control group. Conclusions These data suggest that 11,12 EET added to the cardioplegic solution of St.Thomas Ⅱ has lower incidence rate of reperfusion arrhythmias.

    Release date:2016-08-30 06:27 Export PDF Favorites Scan
  • 体外循环先天性心脏病纠治术对QT离散度的影响及意义

    目的 研究体外循环心脏不停跳心内直视术纠治先天性心脏病对QT离散度(QTd)的影响及其意义.方法 记录20例先天性心脏病纠治术患者术前、术终和术后7天内同步12导联心电图,测定各时间点QTd值和QT离散度校正值(QTcd).结果 术终及术后QTd和QTcd明显升高(P<0.05),术后第2天达最高值,虽然术后第7天仍未能恢复至术前水平,但总体表现为一个缓慢回落的趋势.1例术后频发室性早搏患者及1例术后死于阵发性室性心动过速导致的心跳骤停患者的QTd和QTcd明显高于均值.结论 体外循环直视手术纠治先天性心脏病患者术终、术后QTd和QTcd明显增高,提示心肌细胞复极受影响,与麻醉及手术操作等有关.QTd与QTcd亦有可能作为评价心脏外科手术后心律失常和预后的指标.

    Release date:2016-08-30 06:35 Export PDF Favorites Scan
  • Clinical characteristics and postoperative recurrence factors of 1 106 patients with cardiac myxoma

    Objective To summarize the clinical characteristics and surgical treatment experience of 1 106 patients with cardiac myxoma. Methods Clinical data of 1 106 patients with cardiac myxoma who underwent surgical treatment in Beijing Anzhen Hospital from 2002 to 2018 were retrospectively analyzed. There were 749 (67.7%) females and 357 (32.3%) males. Results The highest incidence rate was at the age of 51-70 years. The location of the disease was: left atrium in 987 (89.2%) patients, right atrium in 99 (9.0%) patients, left ventricle in 10 (0.9%) patients, right ventricle in 8 (0.7%) patients. There were 1 013 patients of heart classification (NYHA) Ⅰ-Ⅱ and 93 patients of Ⅲ-Ⅳ. There were 301 patients with cerebral infarction and 57 patients with peripheral arterial embolism. Tumor size was closely related to hemodynamic symptoms (P≤0.05), but not to peripheral vascular embolism (P>0.05). Two (0.2%) patients died in hospital and 306 patients were followed up, with a follow-up rate of 27.7%. The median follow-up time was 7 years (range, 1-18 years). One patient died of all causes, and 23 patients recurred, with a recurrence rate of 2.1%. Among 23 recurrent patients, 15 (65.2%) patients were atypical myxoma and 8 (34.8%) patients were typical myxoma. There was no statistical difference in aortic clamping time, ICU stay time, ventilator-assisted breathing time, postoperative hospital stay time, postoperative mortality, or cardiac ejection fraction at discharge between the reoperation in 23 recurrent patients and the first operation in 1 083 non-recurrentpatients. Conclusion Cardiac myxoma is more common in middle-aged and elderly women, and it often occurs in the left atrium. The size of cardiac myxoma can affect the hemodynamic changes. Surgical treatment is effective. Atypical myxoma is more common in recurrent patients, and the effect is still satisfactory through surgical treatment.

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