Objective To investigate the trend of breast cancer treatment and prognosis in 30 years. Methods Total 1 092 patients with breast cancer treated in the Peking Union Medical College Hospital between 1975 and 2006 were reviewed in six time phases for therapy, metastasis, and survival rate. Six time phases were 1975-1980 years, 1985-1986 years, 1990-1991 years, 1995-1996 years, 2000-2001 years and 2005-2006 years. Results Radical operation was the major treatment (68.9%， 91/132) of breast cancer in 1975-1980 and then became less popular until it was totally abandoned after 2001. The number of modified radical operation begun to rise from 1980 and reached its peak in 1995-1996 (94.9%， 146/154). The number of lumpectomy had been increasing since 2000, and that of chemotherapy had been rising since 1985-1986. But there was no apparent change of the percentage of radiotherapy treatment. In 1975-1980, only 0.8% （1/126） patients received endocrine therapy, but in 1990-1991, the ratio was 66.0% （33/50）. The metastasis and recurrence ratio was declining gradually in the 6 time phases (P＜0.05). The 5-year and 10-year disease free survival rates in the groups of 1990-1991, 1995-1996, 2000-2001, and 2005-2006 were apparently higher than those in two earlier groups of 1975-1980 and 1985-1986 (P＜0.05). Conclusion The conclusions of laboratory experiments and clinical trials on breast cancer are critical for improving prognosis.
目的 探讨妊娠期乳腺癌的诊断、治疗及预后。方法 回顾性分析1986年1月至2007年12月期间笔者所在医院收治的12例妊娠期乳腺癌患者的临床资料和随访资料。结果 12例妊娠期乳腺癌患者中，有8例患者于术前行B超检查，3例患者行钼靶检查，均有阳性发现。12例患者均行手术治疗，其中10例行乳腺癌改良根治术，2例行乳腺癌根治术；7例在妊娠期间确诊的患者中，仅1例行人流术，另外6例行剖宫产；所有患者乳腺癌术后并妊娠结束后均行化疗，5例化疗后再行放疗，1例在妊娠结束后行内分泌治疗。随访期间（平均随访时间35.8个月），1例患者出现胸壁结节，2例盆腔多发转移并死亡，余9例均未出现复发和转移。结论 妊娠期乳腺癌可行乳腺切除加腋窝淋巴结清扫术； 妊娠结束后可行化疗，妊娠期间不应行放疗及内分泌治疗。