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find Author "周清华" 7 results
  • Irinotecan versus Oxaplatin in Combination with 5-FU/LV for \Advanced Colorectal Cancer: A Systematic Review

    Objective To compare and evaluate the effectiveness and safety of irinotecan (IRI) versus oxaplatin (OXA), in combination with 5-FU/LV for patients with advanced colorectal cancer. Methods The literature search, study selection and assessment, data collection and analysis were undertaken by two reviewers according to the Cochrane Handbook for Systematic Reviews of Interventions. Randomised controlled trials (RCTs) or quasi-RCTs comparing IRI versus OXA, in combination with 5-FU/LV in the treatment of advanced colorectal cancer were collected. Results Seven studies involving 2107 patients were included. The OXA/5-FU/LV regimen was superior or at least equal to the IRI/5-FU/LV regimen in prolonging overall survival and time to progression. The OXA/5-FU/LV regimen showed a higher response rate and was associated with lower toxicities. Conclusion Compared with IRI, OXA is more appropriate for the treatment of advanced colorectal cancer when combined with 5-FU/LV.

    Release date:2016-08-25 03:36 Export PDF Favorites Scan
  • 核增殖抗原表达基因Ki67与人肺癌临床病理生理特征及其预后的关系

    目的 研究细胞增殖状态与肺癌临床病理生理特征和预后的关系,探讨Ki67对临床诊断和预后判断的价值。方法 应用免疫组织化学法检测166例肺癌组织标本和37例肺良性病变组织中Ki67的表达水平。结果 (1)肺癌组织中Ki67指数显著高于肺良性病变组织(P<0.01),而癌旁组织与良性病变组织相比差别无显著性意义;(2)肺癌组织中Ki67表达水平增强与肺癌组织学类型、细胞分化程度有关(P<0.05),而与患者PTNM分期、淋巴结转移程度、吸烟与否以及患者的性别、年龄无明显关系;(3)Ki67高表达组肺癌患者的术后生存时间显著低于低表达组(P<0.01),按PTNM分期分层后这种差别仍然存在(P<0.05)。结论 Ki67能较好地反映肺癌细胞的增殖状态,并对临床诊断和预后判断有一定价值。

    Release date:2016-08-30 06:33 Export PDF Favorites Scan
  • 青年自发性气胸、血气胸的临床分析

    目的 对青年自发性气胸、血气胸发病进行临床分析和手术指征探讨。方法 手术治疗自发性气胸27例,自发性血气胸20例,总结其病史及手术发现。结果 27例自发性气胸中24例发病原因为肺大泡破裂,2例为先天性肺囊肿,1例为疤痕漏气。部分患者肺大泡部位有陈旧性炎性疤痕或结核等基础病变。20例血气胸中16例为胸顶条索状粘连带断裂,2例为肺大泡破裂致肺表面异常血管断裂,2例未见直接出血部位。5例自发性血气胸首先表现为单纯气胸,在病情发展过程中表现出出血征象或继发性血胸。结论 青年自发性气胸发病的病理基础多为肺大泡破裂,应积极行手术治疗;自发性血气胸发病的病理基础多为胸顶纤维索带断裂,应行及时有效的胸腔闭式引流术,部分患者可避免手术或提早手术。

    Release date:2016-08-30 06:33 Export PDF Favorites Scan
  • The efficacy and satisfaction of PBL model in clinical oncology teaching in China: a meta-analysis

    ObjectivesTo systematically review the efficacy of problem-based learning (PBL) model in clinical oncology teaching.MethodsPubMed, EMbase, CNKI, WanFang Data, CBM databases were electronically searched to collect randomized controlled trials (RCTs) of PBL model used in clinical oncology teaching in China from January, 2000 to March, 2019. Two reviewers independently screened the literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 and Stata 12.0 software.ResultsA total of 29 RCTs involving 2 238 subjects were included. The results of meta-analysis showed that: PBL model in clinical oncology teaching was superior to traditional lecture-based learning (LBL) model on the total score (MD=6.50, 95%CI 4.44 to 8.55, P<0.000 01), theoretical knowledge score (MD=4.58, 95%CI 3.38 to 5.78, P<0.000 01), case analysis score (MD=4.26, 95%CI 3.38 to 5.78, P<0.000 01), skill operation score (MD=6.10, 95%CI 4.77 to 7.43, P<0.000 01), overall course satisfaction (RR=1.74, 95%CI 1.34 to 2.27, P<0.000 01), increased learning interest (RR=1.52, 95%CI 1.28 to 1.81, P<0.000 1), improved teamwork cooperation (RR=1.67, 95%CI 1.39 to 2.01, P=0.002), and improved self-study ability (RR=1.51, 95%CI 1.20 to 1.90, P<0.000 1), the differences were statistically significant.ConclusionsCurrent evidence shows that the PBL model can improve clinical teaching effect of oncology and learning satisfaction. Due to limited quality and quantity of the included studies accumulated, more high quality studies are required to verify above conclusion.

    Release date:2019-07-31 02:24 Export PDF Favorites Scan
  • 改良 Hemi-Clamshell 入路:局部晚期肺癌手术入路的新选择

    Release date:2019-06-18 10:20 Export PDF Favorites Scan
  • 原发性纵隔骨肉瘤一例

    Release date:2020-02-26 04:33 Export PDF Favorites Scan
  • The Construction of a Public Health System in Chengdu--From the Point of View of Evidence-based Medicine

    Objective To provide evidence for the construction of municipal public health system in Chengdu based on the existing problems. Method Using the priniple and method of evidence-based medicine, epicemiology and health care management, and the data searching, extraction and envaluation to analyse the current situation and problems of Chengdu’s public health system. also referring such research results from home and abroad with the hope of resolving such problems and make suggestions as to how to deal with this. Results There is a few literatures on the municipal public health system. The insufficient financial support, hardware and software condition deteriorated the serious situation of public health in Chengdu. Conclusions It is suggested that we should establish a managing committee of the public health system of Chengdu, make comprehensive plan to set up 6 professional centers, fund the research on main diseases and key techniques, increase financial appropriations by improving financing mechanism and establish a center for education and staff training.

    Release date:2016-09-07 02:27 Export PDF Favorites Scan
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