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find Author "周蕾蕾" 12 results
  • Diagnosis and Treatment for Pregnancy-Associated Breast Cancer

    Objective To summarize the recent studies on diagnosis and treatment for pregnancy-associated breast cancer (PABC) to provide evidence for diagnosis and treatment for PABC. Methods By PubMed, Medline, and CNKI retrieval system, with “pregnancy-associated breast cancer or PABC, diagnosis of pregnancy-associated breast cancer or PABC, treatment of pregnancy-associated breast cancer or PABC” as key words to retrieval for the recent researches about PABC. All of the publications about studies on diagnosis and treatment for PABC were reviewed and summarized. Results Diagnosis of PABC included ultrasound, mammography, magnetic resonance imaging, needle biopsy, and so on, and the treatment contained surgery, chemotherapy, endocrine therapy, radiation therapy, and targeted therapy. However, when diagnosis and treatment for PABC involved, the impact to patients with pregnancy and fetus must be considered in priority. Conclusions By reviewing the studies of relevant papers about diagnosis and treatment for PABC which can provide a clinical guidance for clinicians. Usage of bevacizumab and lapatinib still needs to further be studied.

    Release date:2016-09-08 10:35 Export PDF Favorites Scan
  • RELATIONSHIP BETWEEN C-erb B-2 ONCOGENE OVEREXPRESSION AND ESTROGEN RECEPTOR, PROGESTIN RECEPTOR IN BREAST CANCER AND ITS PROGNOSTIC SIGNIFICATION

    The overexpression of C-erb B-2 oncogene in breast cancer was examined in 245 cases with immunohistochemical techniques.The results showed that:①Significant associations of C-erb B-2 overexpression with high histological grade (P<0.05), positive axillary node status (P<0.05), advanced clinical stage (P<0.05) and the absence of hormone receptor(P<0.05) were identified in breast cancer.②Overexpression of C-erb B-2 oncogene was related with 5-year and 10-year survival rate, and considered as a prognostic factor for breast cancer independent of axillary node status. Detection of C-erb B-2 oncogene overexpression could be arranged as a regular pathological examination in breast cancer.Combined with axillary node and estrogen receptor, progestin receptor status, the results can be used in determining the prognosis and planing the treatment programme in breast cancer.

    Release date:2016-08-29 09:16 Export PDF Favorites Scan
  • 上期临床病例讨论结果

    Release date:2016-08-29 03:25 Export PDF Favorites Scan
  • Preliminary Study of Correlation Between Androgen or Stathmin Expression in Patients with Triple Negative Breast Cancer and Its Clinicopathologic Factors

    Objective To explore the expressions of androgen (AR) and Stathmin in triple negative breast cancer (TNBC) and analyze the correlation between these expressions and clinicopathologic features. Methods Eighty-three patients who were diagnosed as TNBC and met the inclusion criteria from 2005 to 2009 in the Sichuan Provincial People’s Hospital were collected retrospectively. The expressions of AR and Stathmin in the TNBC tissues by using the method of EnVision immunohistochemistry. The correlation between AR or Stathmin expression and age, tumor size, lymph node status, or histological grade was analyzed by Spearman test. Results The AR and Stathmin positive expression rates in the patients with TNBC were 37.3% (31/83) and 98.8% (82/83), respectively. The AR expression was positively correlated with age(rs=0.302, P=0.006)and pathological grade (rs=0.225, P=0.041), but was not correlated with tumor size or lymph node status. The Stathmin expression was not correlated with age, tumor size, lymph node status, or pathological grade (P>0.05) . Conclusions The AR expression is correlated with the age or pathological grade but Stathmin expression was all not correlated with the clinicopathologic features. AR or Stathmin as a prognosis indicator in patients with TNBC are needed to more research.

    Release date:2016-09-08 10:35 Export PDF Favorites Scan
  • EXPRESSION OF p16 PROTEIN IN BREAST CANCER AND ITS CLINICAL SIGNIFICANCE

    Objective To investigate expression of p16 protein in breast cancer and its clinical significance. Methods Using immunohistochemical techniques (LSAB) the expression of p16 protein in 107 breast carcinomas was examined. Results The positive rate of p16 protein expression was 40.19% (43/107). The p16 protein over expression of the cases surviving ≤5 years and surviving ≥10 years were 8.00% and 75.68% respectively. Conclusion Expression of p16 protein might play an important role in the prognosis of breast cancer.

    Release date:2016-09-08 02:01 Export PDF Favorites Scan
  • 悬吊拉钩在经腹行全胃及近端胃切除术中的应用体会

    我院从1997年至今应用悬吊拉钩开腹切除胃中上部恶性肿瘤116例,男74例,女42例,年龄20~81岁,平均62岁。其中贲门癌38例,胃底癌11例,胃体癌67例。主要表现为上腹疼痛、腹胀、呕吐、呕血、解黑便及腹部包块等。术前均作胃镜或X线钡餐检查,术后病理学诊断浸润型腺癌6例,粘液型腺癌8例,溃疡型腺癌51例,低分化腺癌26例,印戒细胞癌13例,胃平滑肌肉瘤7例,胃恶性淋巴瘤4例,胃体低分化间质肉瘤1例。手术方法: 应用悬吊拉钩经腹行上半胃切除45例,全胃切除71例,其中联合脏器一期切除17例。近端胃大部切除术后食管断端与胃断端大弯侧吻合45例,全胃切除术后食管与空肠RouxenY吻合12例,端侧ρ型吻合及空肠、空吻Y型吻合27例,Braun’s吻合32例。

    Release date:2016-08-28 05:10 Export PDF Favorites Scan
  • 乳腺肿块诊断方法的应用及其评价

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  • Discussion on Relation Between Plasma Homocysteine and Breast Cancer

    Objective To explore the correlation between homocysteine (Hcy) level and the risk of breast cancer,and try to find a new method to reduce the risk factors and benefit for treatment of breast cancer. Methods From January2010 to December 2012, 245 cases of breast cancer (breast cancer group), 109 cases of benign breast tumor (benign breast tumor group), and 78 cases of healthy women (healthy control group) in the Sichuan Provincial People’s Hospital, who were in accordance with the inclusion criteria, were analyzed retrospectively. The difference of Hcy level was compared among three groups. Meanwhile the relation between Hcy level and patients’s age, blood glucose, serum creatinine, estrogen receptor (ER), progesterone receptor (PR), Ki-67 (%), tumor diameter, or axillary lymph node status was analyzed.Results ① The Hcy level was significantly different among the breast cancer group, benign breast tumor group, and healthy control group (P<0.001). The Hcy level of the breast cancer group was significantly higher than those of the benignbreast tumor group (P<0.001) or healthy control group (P<0.001), but the Hcy level was not significantly different bet-ween the benign breast tumor group and healthy control group (P=0.082) . ② The Hcy levels of different types of the breastcancer (type of Luminal A, Luminal B, Her-2, and triple negative) were significantly higher than those of the benign breast tumor group (except for Her-2 type, P<0.05) or healthy control group (P<0.05). ③Plasma Hcy level of the patients with benign and malignant breast tumor was positively correlated with age (r=0.197, P=0.004) or serum creatinine level (r=0.381, P<0.001), but not correlated with blood glucose (r=0.023, P=0.668). ④Plasma Hcy level of the patients with malignant breast tumor was positively correlated with age (r=0.267, P=0.007) or serum creatinine level (r=0.341, P<0.001), but not correlated with blood glucose (r=-0.005, P=0.935), tumor diameter (r=-0.049, P=0.443), axillary lymph node status (r=-0.006, P=0.921), or Ki-67 (%) (rs=-0.029, P=0.650). Conclusions Plasma Hcy level of breast cancer patient is abnormally elevated, and it may have some relation with the occurrence of breast cancer.

    Release date:2016-09-08 10:35 Export PDF Favorites Scan
  • 狄诺塞麦在乳腺癌中的应用

    【摘要】 狄诺塞麦是目前第一个也是唯一获批的特异性靶向核因子κB受体活化因子配体抑制剂类药物。在乳腺癌的治疗中,无论是对于癌症治疗相关性的骨质疏松或者骨转移,狄诺塞麦都能起到很好的治疗作用,具有广阔的应用前景。现就狄诺塞麦的药理特性、治疗机制、临床试验及效果作一阐述。

    Release date:2016-09-08 09:26 Export PDF Favorites Scan
  • OBSERVATION OF THE EFFECT OF β-AESCINUM NARICUM ON PREVENTION OF POSTOPERATIVE EDEMA OF THE ARM IN BREAST CANCER PATIENTS

    目的 探讨β —七叶皂甙钠对乳腺癌术后患侧上肢水肿的预防作用。方法 84例乳腺癌患者配对后分为实验组和对照组。对照组给予手术等常规治疗,实验组术后另给予β —七叶皂甙钠10~20 mg静脉推注,每12小时1次,连用7~10天,观察两组患者术后患侧上肢水肿的发病率。结果 对照组术后患侧上肢水肿发生率为20.93%(9/43),实验组为4.88%(2/41),两组之间差异有显著性意义。结论 β —七叶皂甙钠对乳腺癌术后患侧上肢水肿的发生有预防作用。

    Release date:2016-09-08 02:01 Export PDF Favorites Scan
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