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find Author "唐芯" 5 results
  • Retention rate of Oxcabazepine in children under the age of four with symptomatic epilepsy

    ObjectiveTo investigate the long-term retention rate of Oxcabazepine (OXC) in Chinese young children with symptomatic epilepsy and to evaluate the withdrawal causes of OXC. MethodsClinical features of 89 cases (male/female:48/41) from January.2009 to June.2015 were collected. Patients with symptomatic epilepsy who received mono-or adjunctive therapy with OXC. The initial dose was 10mg/kg/d twice a daily, 3~4weeks to increased to the target dose. OXC doses ranged between 12~53 mg/(kg·d) (mean dose:34.0±8.59 mg/(kg·d). An investigator recorded the antiepileptic drugs, seizure frequency, electroencephalogram and side effects for 3, 6, 12, 24 and 36months during follow-up. ResultsA total of 89 patients were enrolled in this investigation. patients with 50% reduction in seizure frequency in 6, 12, 24 and 36 months were 56.5%, 55.3%, 44.7%, 24.7%, and with seizure-free were 36.5%, 34.1%, 29.4%, 16.5%. In this research, 16(18.0%) patients experienced at least one side effect. The most common side effects observed were drowsiness 8 (42.1%), rash 3 (15.8%), and most were mild in severity. The retention rate of OXC in 3, 6, 12, 24, and 36months were 95.5%, 87.6%, 75.3%, 56.2%, 25.8%, respectively. The predominant causes of withdrawal were lack of efficacy 36(54.5%), end point 10(15.2%), adverse effects 8(12.1%), seizure-free 5(7.6%), follow-up loss 3(4.5%). COX analysis reveals that the age of onset was associated with treatment failure. ConclusionOur study demonstrates that OXC is safe and well tolerated in infants and very young children with symptomatic epilepsy, but the long-term retention rate is low. Whereas, for the purpose of better retention rate and therapeutic benefits, we should treat discretely depending on the complicated etiology and clinical features.

    Release date:2017-01-22 09:09 Export PDF Favorites Scan
  • Efficacy of Cognitive Behavioral Therapy on Mental Health and Social Function in Patients with Multiple Sclerosis: A Meta-analysis

    ObjectiveTo systematically review the efficacy of cognitive behavioral therapy (CBT) for improving mental health and social functions in patients with multiple sclerosis (MS). MethodsWe searched PubMed, EMbase, The Cochrane Library (Issue 4, 2016), CBM and CNKI from inception to May 2016, to collect randomized controlled trials (RCT) about CBT on mental health and social function in patients with MS. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies. Then meta-analysis was performed by using RevMan 5.3 software. ResultsA total of 11 RCTs involving 1 102 patients were included. The results of meta-analysis showed that, the HADS scores (depression: MD=-1.28, 95%CI-2.07 to-0.48, P=0.002; anxiety: MD=-1.52, 95%CI-2.99 to-0.06, P=0.04), BDI scores (MD=-9.11, 95% CI-15.82 to-2.40, P=0.008), HRDS scores (MD=-7.23, 95% CI-13.65 to-0.82, P=0.03), Chalder scores (MD=-4.88, 95% CI-6.61 to-3.16, P < 0.000 01), MFIS scores (MD=-2.98, 95% CI-4.52 to-1.44, P=0.000 2) and GHQ-12 scores (MD=-3.61, 95%CI-5.20 to-2.02, P < 0.000 01) in the CBT group were lower than that in the control group. No significant difference was found in WSAS scores (MD=-1.98, 95%CI-4.88 to 0.93, P=0.18) between two groups. ConclusionCBT may be effective for improving the negative mental experience, fatigue and quality of life in MS. No evidence to support CBT has benefits in social functions. Due to the limited quantity and quality of the included studies, the above conclusion needs to be verified by more high quality studies.

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  • Effects of Tai Chi on negative symptoms and activity participation in patients with schizophrenia: a meta-analysis

    ObjectiveTo systematically review the effectiveness of Tai Chi for improving negative symptoms and activity participation in patients with schizophrenia. MethodsDatabases including PubMed, The Cochrane Library (Issue 3, 2016), EMbase, CBM, CNKI, VIP and WanFang Data were electronically searched to collect the randomized controlled trials (RCTs) and quasi-randomized controlled trials (quasi-RCT) about Tai Chi for improving negative symptoms and activity participation in patients with schizophrenia from inception to Apirl 1st 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed by using RevMan 5.3 software. ResultsA total of three RCTs and two quasi-RCTs were included. The result of meta-analyses showed that no significant difference was found in negative symptom scores (MD=–0.95, 95% CI –3.78 to –1.89, P=0.51) and positive symptoms scores of PANSS (MD=–0.02, 95% CI –0.50 to 0.46, P=0.94) between two groups. However, the Tai Chi group was superior to the control group in items including attention, avolition, anhedonia-asociality, alogia and affective flattening/blunting of SANS (all P values<0.05). ConclusionTai Chi may have positively influence on various negative symptoms in patients with schizophrenia, but no evidence to support the Tai Chi's effects for activities participation. Larger and higher quality studies are needed.

    Release date:2017-02-20 03:49 Export PDF Favorites Scan
  • 基于人-环境-作业模型探究颅脑外伤患者记忆功能康复技术的现况

    认知障碍是颅脑外伤的后遗症之一,其中记忆障碍是最常见的认知受损形式。颅脑外伤患者记忆功能的恢复情况直接影响其独立生活功能及社会参与能力。目前,大量临床研究探究了颅脑外伤后记忆功能的康复策略,其方式可归结为直接提高患者的记忆功能,提供环境支持和对患者所需完成的记忆任务进行改良。记忆康复策略通过个人、环境及作业活动 3 个方面的支持,改善患者的记忆功能,并有效地提高患者在实际的功能活动中的具体表现。该文基于人-环境-作业模式,综述目前已有的颅脑外伤后记忆康复技术相关文献,为临床康复实践提供依据。

    Release date:2017-07-21 03:43 Export PDF Favorites Scan
  • 重复性经颅磁刺激用于脊髓损伤康复的研究进展

    脊髓损伤后由于中枢神经系统的可塑性改变,机体从脊髓损伤平面到上位神经通路均出现一系列继发改变,而这一系列继发改变可能引发脊髓损伤患者的神经病理性疼痛,延缓其运动功能、痉挛状态的恢复过程。因此,对中枢神经系统进行适当的引导和调制将促进患者的康复进程。重复性经颅磁刺激目前已经广泛应用于多种临床康复问题之中,通过无创地影响中枢神经系统活性,调制神经系统重塑,该技术可望成为脊髓损伤康复管理的可选干预措施之一。该文就目前重复性经颅磁刺激对脊髓损伤康复的研究进行综述,并探究其可能的机制和临床实际使用方法,以期促进该技术在脊髓损伤康复中的临床应用。

    Release date:2017-10-27 11:09 Export PDF Favorites Scan
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