目的:目的:观察喜炎平联合干扰素治疗手足口病的临床疗效。 方法:将180例手足口病患儿随机分为治疗组和对照组,每组90例。治疗组喜炎平联合干扰素治疗:静滴喜炎平10 ㎎/㎏.d,干扰素剂量为5万u/㎏.d,皮下注射,疗程7天;对照组以干扰素剂量为5万u/㎏.d,皮下注射,疗程7天。结果:治疗组总有效率为88.9 %,对照组总有效率为76.7 %(P＜0.05),治疗组临床症状及体征明显较对照组消失早(P＜0.05)。 结论:喜炎平联合干扰素治疗手足口病疗效佳,值得临床推广应用。
Xiyanping is used to treat infectious diseases with antibiotics in clinic. The aim of this study is to investigate the mechanism of Xiyanping through studying the effect of the combination of Xiyanping with Cefazolin on the chemotaxis and phagocytic function of peripheral blood neutrophils in mice. Ten healthy mice were in control group. Forty healthy mice in experimental group were infected with staphylococcus aureus, and were randomly divided further into four groups, i.e. model group, Xiyanping group, Cefazolin group and combination group (Xiyanping with Cefazolin). Mice in the control group and model group were given normal saline (NS) through abdomen while those in other groups were given Xiyanping, Cefazolin, and Xiyanping with Cefazolin, respectively. The chemotaxis of peripheral blood neutrophils was detected with the transwell method, and the phagocytic function of peripheral blood neutrophils was analyzed with flow cytometry (FCM). In the present study, there was no significance on the chemotactic index of peripheral blood neutrophils in all the groups (P>0.05). The actual phagocytotic rate and index of peripheral blood neutrophils in the blank group, Xiyanping group, and the combination group were significantly higher than those of the model group and Cefazolin group (P<0.05). However, those were not significant in the blank group, Xiyanping group, and the combination group (P>0.05) or between the model group and Cefazolin group (P>0.05). Our results suggested the combination of Xiyanping and Cefazolin could enhance the therapeutic effect by improving the phagocytic function of peripheral blood neutrophils.