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find Author "喻晶" 3 results
  • Research progress of relationship between chloride intracellular channel protein 1 and colonic cancer

    Objective To summarize research progress of relationship between chloride intracellular channel protein 1 (CLIC1) and colonic cancer. Method The related literatures in recent years on the relationship between the CLIC1 and the colonic cancer were reviewed and analyzed. Results The CLIC1 could play its physiological function as a chloride ion channel, with a wide tissue distribution and high expression in many tumor tissues. The abnormal expression of CLIC1 could result in many diseases and participate in many processes such as the occurrence, development, metastasis, and treatment of the colonic cancer. Conclusions CLIC1 might be a biomarker for early diagnosis and a target for gene therapy of colonic cancer, key genes regulated its expression, signal transduction pathways involved in occurrence and progression of colonic cancer, and interaction with other related molecules are still unclear, and further study is needed.

    Release date:2018-09-11 11:11 Export PDF Favorites Scan
  • 腹腔镜与开腹骶前肿瘤切除术的临床疗效比较

    目的 探讨腹腔镜下骶前肿瘤切除术的可行性和安全性。 方法 回顾性分析 2006 年 3 月至 2015 年 12 月期间于川北医学院附属医院行腹腔镜骶前肿瘤切除术(n=6)或传统开腹骶前肿瘤切除术(n=43)的 49 例原发性骶前肿瘤患者的临床资料,比较腹腔镜组和开腹组患者的术中出血量、手术时间、术后肛门排气时间、住院时间、卧床时间、并发症等临床指标。 结果 所有患者的肿瘤均被完整切除,无一例围手术期死亡。2 组患者的术中出血量、术后肛门排气时间、住院时间及卧床时间比较差异均有统计学意义(P<0.05),与开腹组比较,腹腔镜组的术中出血量少,术后肛门排气早,住院时间和卧床时间均较短;但 2 组患者的手术时间、总并发症发生率、切口并发症发生率、粘连性肠梗阻发生率及肿瘤复发率比较差异均无统计学意义(P>0.05)。出院后所有患者获随访,随访时间 6~24 个月,中位数为 16 个月。随访期间开腹组有 3 例发生肿瘤复发(2 例为恶性畸胎瘤,1 例为脂肪肉瘤),腹腔镜组患者无一例肿瘤复发。 结论 与开腹手术相比,腹腔镜下骶前肿瘤切除术具有术中出血少、术后恢复快、住院时间及卧床时间短的优点,腹腔镜下行原发性骶前肿瘤切除术是安全和可行的。

    Release date:2017-09-18 04:11 Export PDF Favorites Scan
  • Individualized treatment of anastomotic leakage after laparoscopic D2 radical gastrectomy

    ObjectiveTo summarize the experience in the treatment of anastomotic leakage after laparoscopic D2 radical gastrectomy.MethodThe clinicopathologic data of 11 patients with anastomotic leakage after the laparoscopic D2 radical gastrectomy in the Nanchong Central Hospital from May 2016 to January 2018 were analyzed retrospectively.ResultsAmong the 11 patients with anastomotic leakage, 3 were grade Ⅱ leakages and 8 were grade Ⅲa leakages. There were no symptoms in the 3 cases of anastomotic leakage, which were confirmed only by the gastrointestinal radiography and were healed after 7 d of conservative treatment. Among the 8 patients with the clinical symptoms, 5 cases were treated by the endoscopic drainage and negative pressure suction for 60–90 d, 3 cases were treated by the endoscopic covered stent, 2 cases were cured after 30–60 d, and 1 case died of massive bleeding after 45 d.ConclusionsDue to differences of location, time, limitation, and size of anastomotic leakage after laparoscopic D2 radical gastrectomy, individualized treatment should be performed according to specific situation of patients in local treatment. Endoluminal covered stent has certain clinical application value.

    Release date:2020-07-26 02:35 Export PDF Favorites Scan
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