【摘要】 目的 探讨老年人头面部脉管肉瘤的临床病理学特征。 方法 1996年-2008年对5例老年人头面部脉管肉瘤的临床资料、病理形态学、免疫组织化学染色进行观察，并对其中4例进行了随访。 结果 临床表现主要是头面部发生的瘀斑、溃疡或结节状病变。肿瘤细胞围绕皮肤附件周围排列成交通状吻合的血窦网，衬覆有异型性的内皮细胞，有的区域内皮细胞形成乳头状突起。肿瘤组织内有不同程度的弥漫性出血。肿瘤细胞表达CD34、CD31、Fli-1和FⅧ，部分表达CD117和CK8/18。经随访3例3年内死亡，1例带瘤存活1年余，1例失访。 结论 老年人头面部脉管肉瘤组织形态多样，预后较差，及时诊治十分重要。需要与其他皮肤良性血管病变和低分化癌、恶性黑色素瘤、恶性梭形细胞肿瘤、Kaposi肉瘤等鉴别。【Abstract】 Objective To explore the clinicopathological features of cutaneous angiosarcoma on the scalp and face in elder patients. Methods The clinical data of five elder patients with cutaneous angiosarcoma on the scalp and face from 1996 to 2008 were retrospectively analyzed. The patients underwent the light microscopy, pathomorphological examination, and immunohistochemistry. Four patients were followed up. Results Most clinical manifestation was dusky irregular erythematous plaques which were often ulcerated. The tumor was composed of asymmetric collection of angulated and irregular vascular spaces infiltrating between collagen bundles. Endothelial cells attaching to the vascular spaces had hyperchromatic irregular nuclei and prominent nucleoli. Hemorrhage was another histologic feature. Positive expression of CD34,CD31,Fli-1 and FⅧ were found in tumor cells, and expression of CD117 and CK8/18 was found in some of the patients. In the follow-up duration, three patients died in three years, and one failed to be followed up. Conclusion Cutaneous angiosarcoma of the scalp and face has various histomorphology and poor prognosis, which should be diagnosed and treated in time. It should be distinguished from benign cutaneous hemangioma, poorly differentiated carcinoma, malignant melanoma and malignant spindle cell tumor.
Objective To discuss the operative method and experience, through analyzing the medium-term and long-term effect of combined therapy for cutaneous squamous cancer of head and face. Methods From January 1998to December 2002, 37 patients with head or neck cutaneous squamous cancer received combined therapy of operation and radiation. The determination of resect area was based on the stage of the tumor, and according to the resect area and the freedom of peripheral tissue, 3 different operation procedures were adopted respectively. The follow-up was ended in June 2004. Results The follow-up was 5 to 69 months. The median follow-up interval was 38 months. Four patients (10.8%) relapsed during the follow-up, and 2 of them (5.4%) relapsed within 3 years after operation. two patients (5.4%) died from the primary affection, 4 patients (10.8%) died from other causes. According to Kaplan-Meier Method, the 3-year survival rate was 97.14% and the standard error was 0.0358, and 5-year survival rate was 92.28% and the standard error was 0.1047. Conclusion The recurrence rate of cutaneous squamous cancer of head and face witha better prognosis is lower than the ones from other origins. And the survival rate may be improved from proper operative method.
OBJECTIVE To evaluate the effect of tissue flap pedicled with the superficial temporal artery in repairing deformity of the head and face in children. METHODS From October 1986 to December 1996, 13 children with deformity of the head and face were repaired by this tissue flap. Among them, there were congenital deformity in 9 cases, burned scar in 3 cases and infection scar in 1 case. Among the flaps, 1 was temporal skin flap, 3 were temporal flap with hairbearing scalp, 1 was frontal skin flap, and 8 were posterio-uricular superficial fascia flap and skin flap. The area of tissue flap was ranged from 5.0 cm x 1.2 cm to 10.0 cm x 5.0 cm. The length of the pedicle was 5-8 cm. RESULTS All tissue flaps healed with first intention. Followed up for 6 months to 12 years, the appearance and function of tissue flaps were satisfactory. CONCLUSION The tissue flap pedicled with the superficial temporal artery is suitable to repair many kinds of deformities of the head and face in children. It has the advantages of good blood supply, closely acceptor area, easy operation and satisfactory appearance.
目的:探讨头面部皮肤恶性肿瘤采用Mohs手术和整形技术联合应用的治疗效果。方法:37例皮肤恶性肿瘤分为Mohs治疗组12例,普通手术组25例,并对切取肿瘤创面采用肌皮瓣、皮瓣、游离皮片,或直接缝合方式修复。结果: Mohs治疗组病例伤口Ⅰ期愈合,皮瓣全部成活,随访2年无复发。普通手术组病例伤口及皮瓣愈合好,但在2年随访中有4例复发(16%)。结论: Mohs手术和整形技术联合应用是治疗皮肤恶性肿瘤的最佳方法。