Objective To review the studies on Oddi′s sphincter motility in recent years. Methods The studies on exploration and evaluation of normal or abnormal Oddi′s sphincter motility by means of electromyography, dynamic hepatobiliary scintigraphy, endoscopic manometry, and laboratory tests were reviewed. Results Endoscopic manometry was the gold standard for distinguishing normal motility from the abnormal. Some surgeries and drugs could lead to the sphincter of Oddi dysfunction. Conclusion The sphincter of Oddi dysfunction can be treated with endoscopic sphincterotomy. Preservation of sphincter function is stressed in surgery.