目的 探讨老年人结肠脾曲综合征的诊治方法。方法 对1993年9月至2003年9月收治的22例老年人结肠脾曲综合征患者的临床资料进行回顾性分析。结果 临床表现为便秘伴腹痛、腹胀、消瘦、头痛、头晕、心悸、腹膜炎等； X线钡剂灌肠造影检查示结肠脾曲过高、迂曲成角，甚至扭转，可伴有横结肠冗长。行横结肠与降结肠侧侧吻合术，切除冗长结肠，随访2～8年，疗效满意。结论 对老年结肠脾曲综合征患者，钡剂灌肠检查应是常规检查，一旦确诊，应手术治疗。
Objective To explore the differential expression of circular RNAs (circRNAs) in polycystic ovary syndrome (PCOS) by bioinformatics, and predict the microRNAs (miRNAs) associated with them. Methods The expression profile of cumulus cells gene chip in PCOS was searched in the Gene Expression Omnibus database, and differential circRNAs were screened by GEO2R tool of the database. The Gene Ontology and Kyoto Encyclopedia of Genes and Genomes signaling pathways of different circRNA genes were analyzed using the DAVID 6.8 database. Circular RNA interactome was used to predict the potential regulated miRNAs. Cytoscape software was used to establish circRNA-miRNA network map. The potential regulatory miRNAs were predicted by the 10 circRNAs with the most significant differences in up-regulation and down-regulation. Results A total of 247 circRNAs were obtained in PCOS, and 277 miRNAs binding to up-regulated circRNA genes and 125 miRNAs binding to down-regulated circRNA genes were predicted. The top 10 miRNAs that could bind to multiple differential circRNAs were hsa-miR-557, hsa-miR-507, hsa-miR-224, hsa-miR-136, hsa-miR-127-5p, hsa-miR-579, hsa-miR-502-5p, hsa-miR-186, hsa-miR-1253, and hsa-miR-432. Conclusion The differential expression analysis of circRNAs is helpful to understand the main role of circRNAs in PCOS, and the prediction of potential regulated miRNAs can help to understand the pathogenesis of the disease.