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find Author "季昭臣" 8 results
  • Causes and countermeasures of waste in clinical research of Chinese medicine

    The issue of waste in medical research has been widely concerned in recent years. Research waste is also significant in the field of traditional Chinese medicine (TCM). This study summarized the causes of research waste in TCM and provided suggestions to researchers and administrators for reducing research waste and promoting rational use of medical research resources.

    Release date:2018-11-16 04:17 Export PDF Favorites Scan
  • Efficacy and safety of Yangzhengxiaoji capsule combined with chemotherapy for malignant digestive tract tumor: a meta-analysis

    Objectives To systematically review the efficacy and safety of Yangzhengxiaoji capsule combined with chemotherapy for malignant digestive tract tumor. Methods CNKI, WanFang Data, PubMed, EMbase, SinoMed and The Cochrane Library databases were searched online to collect randomized controlled trials (RCTs) of Yangzhengxiaoji capsule combined with chemotherapy for malignant tumor of digestive tract from inception to November 20th, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Meta-analysis was then performed using ReMan 5.3 software. Resluts A total of 15 RCTs were included. The results of meta-analysis showed that: compared with the chemotherapy alone, Yangzhengxiaoji capsule combined with chemotherapy could significantly improve the disease control rate (RR=1.26, 95%CI 1.07 to 1.49, P<0.000 01), the clinical efficacy of TCM syndrome (RR=1.71, 95%CI 1.50 to 1.96,P<0.000 01), and the quality of life scores of patients (RR=1.44, 95%CI 1.13 to 1.82,P=0.003). The combination therapy could also improve the immune function of patients and reduce the incidence of adverse reactions. Conclusions Current evidence shows that chemotherapy combined with Yangzhengxiaoji capsule is superior to chemotherapy alone for disease control of malignant tumor of digestive tract, clinical efficacy of TCM syndrome, the quality of life, and improving immune function. Due to limited quality and quantity of the included studies, more high quality studies are required to verify above conclusions.

    Release date:2018-01-20 10:09 Export PDF Favorites Scan
  • 译文:核心指标集研制标准:COS-STAD 推荐

    背景 核心指标集(Core Outcome Set,COS)的应用是为确保研究人员测量并报告那些与其研究最可能相关的结局指标。目前,已开展数百个 COS 研究,但还没有对这些研究进行正式的质量评价。核心指标集研制标准(Core Outcome Set-STAndards for Development,COS-STAD)项目目的是制定国际工作组公认的 COS 研究最低设计标准,而对于 COS 研究的最终报告还有其他具体指南:COS-STAR(Core Outcome Set-STAndards for Reporting,COS-STAR)。 方法与结果 一个由经验丰富的 COS 研制者、方法学家、期刊编辑、COS 潜在使用者(临床试验员、系统评价员和临床指南制定者)及患者代表组成的国际组织制定了 COS-STAD 推荐,用以帮助改善 COS 的研制质量,并为判断已经形成的 COS 所采用的方法是否恰当提供评估支撑。通过公开的专家问卷调查产生了一份初始条目清单,并经两轮德尔菲(Delphi)问卷调查优化,共有近 250 名来自关键利益相关方的代表参加。参与者使用一个 1~9 分的量表为每个条目的重要性打分。某个条目可以进入到最低标准集合的共识原则是,每个相关方的投票参与者中至少有 70%对该条目打分为 7~9 分。德尔菲调查之后,还要与代表多个相关方的研究管理组进行共识讨论。COS-STAD 包含 11 条最低标准,是所有 COS 研究项目的最低设计建议规范。本推荐重点包括 3 个关键领域:范围、相关方和共识过程。 结论 COS-STAD 项目确立了 11 条最低标准,供 COS 研制者设计研究项目和 COS 使用者判断已形成的 COS 研究方法学是否应用合理。

    Release date:2018-07-18 02:49 Export PDF Favorites Scan
  • Construction and application of clinical evidence database of traditional Chinese medicine

    To describe the construction and application of clinical evidence database of traditional Chinese medicine (TCM-CED) so as to provide evidence for TCM research. The construction process primarily includes: expert team building, TCM-CED function module design, evidence collection and quality control. The applications of TCM-CED primarily include the following aspects: automatic generation of systematic review/meta-analysis in TCM, automatic generation of evidence reports on dominant diseases of TCM, automatic generation of evidence index of Chinese patent medicine, optimizing the selection of outcomes in TCM research, tracking methodological and reporting quality of TCM research, and promoting international dissemination of TCM evidence. With the rapid development of information technology and artificial intelligence, TCM-CED will be combined with artificial intelligence to achieve the construction of all-dimensional TCM evidence chain and the automation of the whole process.

    Release date:2021-04-23 04:04 Export PDF Favorites Scan
  • The design and construction of clinical practice guidelines database of traditional Chinese medicine (G-TCM)

    To promote the accessibility and application of guidelines, it is necessary to establish a professional guideline database to adapt to the rapid growth of TCM clinical practice guidelines. This study described the framework design, technology module, information management, and quality control of the clinical practice guideline database of traditional Chinese medicine (G-TCM). G-TCM had included 658 TCM clinical practice guidelines, which would provide a platform for clinicians, researchers, guideline makers (revision), and evaluators to quickly query and obtain clinical guideline information, and play a supporting role in promoting the standardization and accessibility of TCM clinical practice guidelines and better guiding clinical practice.

    Release date:2021-06-18 02:04 Export PDF Favorites Scan
  • Clinical outcome assessment (COA) accreditation methods and progress

    To ensure the scientific and recognized evaluation of patient-centered clinical research outcomes, the drug development tool qualification certification website of the Center for Drug Evaluation and Research and the Center for Biologics Evaluation and Research have disclosed the information of clinical outcome assessment (COA) submitted for certification, and encouraged the use of certified COA. This paper searched all COA and approval decisions on the website, analyzed the submitted information and certification status of COA, and interpreted the certification technology and process of COA, so as to provide references and suggestions for the development of patient-centered clinical research outcome evaluation.

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  • The regularity of prescriptions of traditional Chinese medicine in the treatment of syndrome of Shi-Re-Huo-Du based on complex network analyses

    ObjectiveTo analysis the regularity of prescriptions of Chinese Medicine for syndrome of intense fire and heat (syndrome of Shi-Re-Huo-Du), and to provide evidences for the clinical treatment.MethodsCNKI, Sinomed, WanFang Data, VIP and Chinese medical databases were electronically searched to collect literatures about traditional Chinese Medicine for syndrome of Shi-Re-Huo-Du from inception to October, 2018. Two reviewers independently screened literature and extracted data. Then BICOMS 2 software was used to generate the co-occurrence matrix, NetDraw software was used to draw network maps.ResultsA total of 381 literatures involving 335 patients were included. There were 716 prescriptions of Shi-Re-Huo-Du (390 Chinese medicinal herbs), in which the frequently used herb included radix glycyrrhizae (346), Scutellariae Radix (255), Fructus Gardeniae (241), Rehmanniae Radix (239), Moutan Cortex (218), etc. The classification was performed according to traditional efficacy, Qing-re herbs (73), Bu-xu herbs (47), and Hua-tan-zhi-ke-ping-chuan herbs (39), accounted for 40.77% of the total herbs. The results of the analysis showed that the top herbs in Degree and Betweenness were consistent with high-frequency herbs. Among them, Rehmanniae Radix, Fructus Gardeniae, Scutellariae Radix, Moutan Cortex are the most important traditional Chinese herbs. High-frequency herbs are mainly based on Qing-re herbs, and the highest frequency of the herbs combination is Scutellariae Radix-Fructus Gardeniae.ConclusionAlthough there are kinds of herbs for syndrome of Shi-Re-Huo-Du, the commonly used herbs are relatively concentrated, and there is obvious interaction between high-frequency herbs, which is in line with the principle of compatibility of Chinese medicine. The high-frequency Chinese herbs and herb pairs were main components of the Chinese patent medicines and classic prescription. It reflected the rule of medicine used and essence in the treatment of syndrome of Shi-Re-Huo-Du.

    Release date:2020-03-13 01:50 Export PDF Favorites Scan
  • Construction of the systematic review/meta-analysis database of traditional Chinese medicine

    The systematic review/meta-analysis database of traditional Chinese medicine (SMD-TCM) was focused on incubation and application of the secondary research achievement. At present, the establishment of front and back websites, evidence input and evaluation have been completed. In the near future, the automation of overview and the visual presentation of evidence information will be realized, which provides the technical support for integration, analysis and application of evidence in the secondary research of TCM. This paper introduces the construction of SMD-TCM database which includes: requirements of construction, design principles, working process, evidence processing, ensuring quality of data input, data analysis and application, etc.

    Release date:2020-02-04 09:06 Export PDF Favorites Scan
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