目的:探讨坎地沙坦与依那普利联合应用对高血压合并左心室肥厚患者血压及左室重构的影响。方法:选择65例高血压合左心室肥厚患者为研究对象,随机分为2组,分别给予坎地沙坦和坎地沙坦与依那普利联合治疗,疗程共26周。采用彩色超声技术测定治疗前、后左心室肥厚的参数变化,并记录血压的变化。结果:坎地沙坦与依那普利联合应用能明显改善高血压患者左室舒张功能，逆转左室肥厚(Plt;005);坎地沙坦单用或与依那普利联合应用均能明显降低血压(Plt;005),但二者联合应用的降压效果与坎地沙坦单独应用的效果相比,差异没有显著性意义(Pgt;005)。 结论:坎地沙坦与依那普利联合应用具有较好的降压效果,并能明显阻断心室重构、改善心脏功能。
【摘要】 目的 观察原发性高血压左心室肥厚患者的心律失常情况。 方法 对2000年1月-2009年10月收治的251例原发性高血压患者进行超声心动图及Holter检查，比较有左心室肥厚（left ventricular hypertrophy，LVH）及无LVH两组各类心律失常的发生情况。 结果 LVH组各种心律失常的发生率与非LVH组比较，差异有统计学意义（Plt;0.01）。LVH组室性心律失常及复杂性室性心律失常的检出率为83.33%和51.85%，明显高于非LVH组（28.67%和9.09%），差异有统计学意义（Plt;0.01）。 结论 高血压并发LVH与心律失常的发生有一定密切关系。【Abstract】 Objective To analyze the condition of arrhythmia in the patients with primary hypertension combined with left ventricular hypertrophy. Methods A total of 251 patients with primary hypertension from January 2000 to October 2009 were selected. All the patients had undergone the examinations of ultrasonic cardiogram, 12-lead electrocardiogram and Holter test to compare the incidence of arrhythmia between LVH and non-LVH group. Results There were significant differences in the incidences of arrhythmia between the two groups (Plt;0.01). Furthermore, the incidence of ventricular arrhythmias and complexity of ventricular arrhythmias of the patients in LVH group was 83.33% and 51.85% respectively, significantly higher than that in non-LVH group (28.67% and 9.09%; Plt;0.01). Conclusion Primary hypertension combined with LVH is relevant to arrhythmias.
目的:观察缬沙坦逆转轻中度原发性高血压左室肥厚的疗效。方法:采用自身对照试验, 116 例轻中度原发性高血压伴左室肥厚的患者, 服用缬沙坦80～160mg/d, 共36 周, 随访患者血压、超声心动图及不良反应。结果: 116例患者治疗后血压明显下降(Plt;0.05), 左心室舒末内径(LVDd)、室间隔厚度(IVST) 、心室后壁厚度(PWT) 、左室重指数(LVMI) 均明显减少 (P 均lt;0.01),无明显不良反应。结论: 缬沙坦治疗轻中度原发性高血压疗效确切, 有效逆转左室肥厚。
目的:探讨24 h平均脉压(PP)对高血压病患者左心室肥厚(LVH)的影响。方法:入选原发性高血压病患者136 例,进行24 h 动态血压监测和超声心动图检查。根据24 h 平均脉压水平各分为3组进行比较。结果:24 h平均脉压与年龄、左心室重量指数、动脉僵硬度指数有显著的相关性。结论:脉压升高是老年高血压病患者左心室肥厚的重要危险因素。
ObjectiveTo evaluate the effects of combined bisoprolol and candesartan therapy on left ventricular hypertrophy and left heart function in in elderly patients with hypertension. MethodsFrom July 2011 to August 2012, 117 elderly inpatients or outpatients with hypertension in our hospital were randomly divided into trial group and control group. Patients in the control group received levamlodipine besylate and bisoprolol, and patients in the trial group received candesartan and bisoprolol. ResultsThere was no statistical difference between the two groups at baseline. Three months later, there was no obvious difference of the blood pressure levels between the two groups (P>0.05). The parameters of left ventricular hypertrophy and left heart function were improved at the end of follow-up in both the two groups, but the parameters of the trial group improved better than the control group (P<0.05). ConclusionIn the elderly patients with hypertension, the combined bisoprolol and candesartan or levamlodipine besylate and bisoprolol therapy can improve left ventricular hypertrophy and left heart function, and the results are better for the combination of bisoprolol and candesartan.