Shortly after the earthquake in Min county and Zhang county, the department of health of Gansu province immediately established a leadership team for earthquake relief and medical rescue, subordinated by psychological crisis intervention teams, which was responsible for training relevant personnel to carry out psychological intervention, and spreading related knowledge about earthquake. Then, emergency psychological intervention was provided for the key population (more than 90 times in total, involving 8 194 person-times). We also offered individualized psychological services (617 person-times), and diagnosed 31 patients with mental disorders through consultation. After the earthquake, the emotion of victims including depression, anxiety and acute stress disorder increased. The workload of psychological crisis intervention after earthquake was heavy and hard. However, Gansu province needs national support due to poor resources.
鉴于慢性阻塞性肺疾病(COPD)的气流受限特点是进行性发展，而且不能完全可逆，同时COPD带来沉重的社会经济负担，成为劳动力丧失和死亡的重要原因之一。因而近年来国外一些学者主张早期干预COPD，并且提出许多理由，诸如早期干预COPD可以减少症状，减少动态过度充气，改善肺功能，提高生命质量等。然而，必须看到COPD的早期干预是一项很艰难的系统工程，有许多问题需要大家认真思考和讨论，尤其是在我国这个问题尤为重要和复杂。故愿就我国COPD的早期干预问题谈一些不成熟的看法，以就正于同道。
Shortly after the Wenchuan earthquake, we established headquarter of crisis intervention, which was responsible for reporting earthquake situation and training personnel to carry out psychological intervention and publicize earthquake-related knowledge. Then, urgent psychological intervention was provided to the target populations. We offered crisis intervention more than 100 times (40,000 person-times), provided individualized psychological services or therapies over 3,000 person-times and treated more than 200 patients with posttraumatic stress disorder. Meanwhile, we established relevant administration systems including registration, reporting, rapid screening and personnel work logs. Our preliminary survey conducted 1 month after the earthquake showed that the prevalence of posttraumatic stress disorder reached 43%. After the earthquake, the victims’ emotions of depression and anxiety were raised and the prevalence of posttraumatic stress disorder had a sharp increase. The victims’ requirements for psychological crisis intervention after earthquake were immense.
Objective To systematically evaluate the effects of psychotherapy for cancer patients with depression. Methods We searched The Cochrane Library, PubMed, EMbase, Chinese Biomedical Literature Database, Chinese Scientific Journals Full-text Database, and Chinese Journal Full-text Database up to October 2010 to identify randomized controlled trials (RCTs) comparing psychotherapy plus conventional treatment with conventional treatment alone. The data were analyzed by using RevMan 5.0 software. Results Eleven RCTs involving 1 670 participants were included. The results of meta-analyses showed: (1) A significant difference was found between psychotherapy plus conventional treatment and conventional treatment alone in decrease of depression score (SMD= – 0.40, 95%CI – 0.70 to – 0.11); (2) No difference was observed between the two groups in decrease of anxiety score (SMD= – 0.68, 95%CI – 1.37 to 0.01), but the result was changed when a sensitivity analysis was done (SMD= – 0.30, 95%CI – 0.52 to -0.08). Conclusion Compared with conventional treatment alone, psychotherapy combined with conventional treatment could improve depressive states in cancer patients, but the result still needs to be confirmed by high-quality and large-sample RCTs.
With the development of interventional therapy technology, trans radial access (TRA) has gradually become the main approach of interventional therapy. Compared with trans femoral access (TFA), TRA has obvious advantages, which can shorten the time of lying in bed and reduce the incidence of complications. However, the radial artery is thinner than the femoral artery, the incidence of spasm is high, and the success rate of puncture is low, so the technical level of operation is required to be high. Nowadays, TRA has been gradually applied to lung cancer, aortic disease, hepatocellular carcinoma, spleen disease, renal artery disease, and other peripheral vascular diseases. With the confirmation of the safety and feasibility of TRA in interventional therapy in different fields, the popularization of TRA in different interventional fields will be supported.
Objective To systematically review simple hypertension guidelines through methods as follows: (a) compare differences and similarities of the recommended drugs; (b) analyze differences of the recommended frequencies in different regions and quality levels; and (c) explore the recommended evidence basis, so as to better understand relevant guidelines. Methods Uncomplicated hypertension guidelines concerning pharmacological interventions were identified (terminated by March 2012) in Ovid, EMbase, Chinese Biomedical Disc (CBM) and WangFang database as well as guideline websites including NGC (National Guideline Clearinghouse), GIN(Guidelines International Network), NICE(National Institute for Health and Clinical Excellence) and CPGN (Clinical Practice Guideline Net, guidelines concerning pharmacological intervention in simple hypertension were included. A total of 6 domains (involving 23 items) in the Appraisal of Guidelines for Research and Evaluation (AGREE) were applied to assess the methodological quality of the guidelines. A comparative study was performed regarding the recommendations in guidelines from different regions as well as of different methodological qualities. Results A total of 27 guidelines concerning pharmacological intervention in simple hypertension were included, involving 6 continents, 13 counties, 3 regions and 3 international organizations. Publication dates ranged from 2003 to 2012. According to the AGREE instrument, 4, 17 and 6 guidelines were graded as Level A, B and C, respectively. There were only 2 domains, “Scope and Purpose” and “Clarity of Presentations”, getting high average scores (more than 60%) among all guidelines. The average scores of guidelines in different domains of AGREE varied with regions. There were 8 evidence-based guidelines which got higher average scores in each domain of AGREE than those of non-evidence-based guidelines. Guidelines varied with the standards of classifying ideal, normal, high normal blood pressure and hypertension. Diuretics were the first agent recommended by all guidelines, and the other recommendations were correlated with age and race. There was a tendency to recommend diuretics as basic drugs in two-drug combination therapy in North America, while calcium channel blockers (CCBs) were the most recommended agents in Asian guidelines. Conclusion The overall methodological quality of simple hypertension guidelines is suboptimal in different countries or regions. The 6 domains involving 23 items in AGREE vary with scores, while the scores of evidence-based guidelines are higher than those of non-evidence-based guidelines. There are differences in the standards of classifying ideal, normal, high normal blood pressure and hypertension. The first-line drug recommendations differ in regions and relate to age and race. Two-drug combination therapy regimens also vary with region.
ObjectiveTo systematically review the economic evaluation research of anti-novel coronavirus infection drugs at home and abroad, so as to promote clinical rational drug use. MethodsThe PubMed, Cochrane Library, EMbase, Web of Science, INAHTA, SinoMed, WanFang Data, and CNKI databases were systematically searched from January 1, 2020 to March 25, 2023, to collect economic evaluation studies related to anti-novel coronavirus infection drugs. ResultsA total of 22 articles were included, among which 11 studies were conducted from the perspective of health system, and most of the studies performed cost estimation on direct medical costs. The overall compliance rate of the included studies ranged from 42% to 70%, with deficiencies in model setting, incomplete uncertainty analysis, and lack of stakeholder participation. The results showed that immunotherapy drugs (Dexamethasone, Tocilizumab), neutralizing antibody (REGEN-COV antibody), small molecule drugs (Baricitinib, Nirmatrelvir/Ritonavir, Molnupiravir, Favipiravir) and statin were cost-effective. There was some variation in the results of the economic evaluation of Remdesivir. ConclusionAt present, there are few studies on the economic evaluation of drug interventions in COVID-19. Existing studies have pointed out that most drug interventions are cost-effective. It is suggested that more standardized pharmacoeconomic evaluation studies based on the actual situation of China epidemic should be carried out in the future.
目的:观察护理干预对脑瘫患儿生活自理能力训练的影响。方法:80例脑瘫患儿随机分为2组,常规组40例,实施常规护理;观察组40例,在常规护理基础上对患儿和家长给予护理干预,两组患儿治疗前后均进行日常生活自理动作评定。结果:治疗后,2组患儿ADL评分较治疗前有明显提高(Plt;0.05),与常规组比较,观察组患儿改善更明显(Plt;0.01)。结论:护理干预对脑瘫患儿生活自理能力的训练有促进作用。