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find Author "张家骅" 3 results
  • EFFECT OF INTRAPERITONEAL HYPERTHERMO-CHEMOTHERAPY ON T-LYMPHOCYTE SUBSETS AND sIL2R LEVEL IN PATIENTS WITH GASTROINTESTINAL MALIGNANCY TUMOR

    To evaluate the effect of intraperitoneal hyperthermo-chemotherapy (IPHC) on immunologic function of patients with gastrointestinal malignant tumor (GMT). The authors determined the serum T-lymphocyte subsets (T-LS) and interleukin-2 receptor (sIL-2R) of 32 patients with GMT after IPHC, and compared the two indexes with 20 healthy control group. Results: Before IPHC the serum CD+3, CD+4, CD+8 and CD+4/CD+8 were higher and sIL-2R were lower than control group, after IPHC, CD+3, CD+4, CD+8 and CD+4/CD+8 increased obviously (P<0.01) and the serum sIL-2R decreased significantly (P<0.01). Conclusion: The IPHC can improve the patients immunologic function.

    Release date:2016-08-29 09:18 Export PDF Favorites Scan
  • 恶性梗阻性黄疸患者手术前后IAP和sIL-2水平变化的意义

    Release date:2016-08-29 09:20 Export PDF Favorites Scan
  • Effects of Edaravone on Lung Injury of Severe Acute Pancreatitis in Rats

    Objective To study the effects of edaravone on the lung injury of severe acute pancreatitis (SAP) in rats. Methods Thirty-six SD rats were randomly divided into three groups: normal control group, model group and edaravone group, and SAP was induced by intraductal administration of 5% sodium taurocholate. Edaravone was given in edaravone group, while normal saline was given in normal control group and model group. After operation 6 h rats were executed, and dry/wet weight (D/W) ratio of lung was counted, and malondialdehyde (MDA) content, superoxide dismutase (SOD) activity in serum and lung were detected, respectively. In addition, the levels of tumor necrosis factor-α (TNF-α), interleukin-1, -6 (IL-1, -6) of serum were detected.Results The MDA contentof serum and lung and the levels of TNF-α, IL-1, IL-6 in model group were markedly higher than those in normal control group and edaravone group, but D/W ratio of lung, SOD activity of serum and lung were significantly lower (Plt;0.05). Conclusion Edaravone can alleviate lung injury of rats caused by SAP.

    Release date:2016-09-08 10:50 Export PDF Favorites Scan
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