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find Author "张海波" 42 results
  • 第四届安贞心脏瓣膜介入治疗新技术高峰论坛暨心脏全瓣膜介入技术Workshop培训工坊会议纪要

    Release date:2023-08-31 05:57 Export PDF Favorites Scan
  • Chinese expert consensus on surgical treatment of congenital heart disease (11): Coarctation of the aorta and interrupted aortic arch

    Coarctation of the aorta and interrupted aortic arch are congenital anomalies affecting the aortic arch. Because of the poor natural prognosis, many patients will need early surgical repair or even emergency surgery. With the improvement of the surgical techniques, cardiopulmonary bypass techniques and perioperative intensive care, surgical mortality has now dramatically decreased. However, aortic arch restenosis, left ventricular outflow tract obstruction and long-term hypertension are problems that may be still encountered during the follow-up period. By reviewing large amounts of literature and discussing among experts, we achieved a consensus on many aspects of the management strategy. We hope this consensus will help Chinese colleagues further improve the overall surgical outcomes of coarctation of aorta and interrupted aortic arch.

    Release date:2020-12-07 01:26 Export PDF Favorites Scan
  • 低温保护时心肌快速冷挛缩的研究进展

    心肌低温保护时快速冷挛缩(rapid cooling contracture,RCC)现象近来日益受到人们重视。快速冷挛缩现象是指快速制冷诱发的非去极化的心肌挛缩。其机制可能与心肌细胞内温度依赖性Ca2+快速升高有关。降温过程中,肌浆网内存Ca2+迅速释放,并与肌钙蛋白相结合,引起蛋白构象发生变化,通过粗、细肌丝相对滑行而产生心肌收缩。快速冷挛缩的危害为能量的消耗、冠状血管阻抗增大、心脏功能降低、Ca2+超负荷等方面,尤其对于未成熟心肌危害更大。目前有些学者提出用心肌温保护和预防Ca2+超负荷等方法来避免其危害的发生。

    Release date:2016-08-30 06:33 Export PDF Favorites Scan
  • 同种带瓣大动脉重建右心室流出道

    摘要目的 应用自行采集和冷冻保存的同种带瓣大动脉(VHC)完成先天性心脏病右心室流出道的重建,并观察其疗效及存在的问题。方法 用VHC材料治疗先天性心脏病95例,90例手术根治,5例行VHC右心室流出道与肺动脉连接姑息手术。结果 院内死亡13例;术后随访68例,死亡2例,均为感染。66例长期生存者中25例胸部X线片示VHC有钙化,多为主动脉材料,仅5例有轻中度压力阶差(35~60mmHg)。结论 VHC可广泛用于治疗复杂先天性心脏病。程序降温、超低温保存和两步化冻是VHC使用质量的保证。VHC的长期通畅比合成管道好,随植入时间延长钙化率增加,肺动脉VHC优于主动脉。有肺动脉高压者宜尽早手术。为了预防VHC植入后感染,应重视、改进其收集和保存的方法。

    Release date:2016-08-30 06:33 Export PDF Favorites Scan
  • Surgical Treatment of Sinus Venosus Atrial Septai Defect

    Objective To summarize the experiences of surgical treatment of sinus venosus atrial septal defect (SVASD). Methods There were 32 patients of SVASD, all of them were associated with totally or partially right anomalous pulmonary venous connection. There were 25 cases of superior SVASD, 22 cases underwent double-patch procedure, 3 cases underwent Warden procedure. In 7 cases of inferier SVASD, 3 cases of Scimitar syndrome underwent ASD repair by pericardial patch and at the same time the anomalous pulmonary vein was divided and reimplanted to the posterior wall of left atrium, 4 cases of them underwent single-patch ASD repair. Results The surgical results were satisfying and no patient died, 28 patients were in sinus rhythm and echocardiography showed neither obstruction of caval vein and right pulmonary vein nor residual interatrial shunt. Conclusion SVASD mostly associated with right anomalous pulmonary venous connection according to its special anatomic structure. Preserving the function of sinus node and avoiding of obstruction of caval vein should be routinely considered when superior SVASD was repaired. The heart function of Scimitar syndrome should be followed-up for a long time for it usually associated with right lung hypoplasia.

    Release date:2016-08-30 06:18 Export PDF Favorites Scan
  • 膜式氧合器在胎羊体外循环中的运用

    目的 为了改进胎羊体外循环技术,探讨膜式氧合器在胎羊体外循环中的应用. 方法 将健康怀孕山羊8只,采用Dideco 901膜式氧合器和滚轴泵建立胎羊体外循环,常温(37℃)转流60分钟,氧合器内充低氧混合气体(8% O2和92% N2),监测胎羊的血压、心率、血气、血清乳酸和胎盘血管阻力. 结果 胎羊体外循环中动脉氧分压(PO2)和二氧化碳分压(PCO2)维持在宫内生理水平,胎羊心搏有力,血压正常.但胎羊pH值缓慢下降(P<0.05),血清乳酸值明显增高(P<0.01),胎盘血管阻力显著上升(P<0.01).停体外循环后胎羊出现低氧、高碳酸血症和酸中毒. 结论 胎羊体外循环影响胎盘功能,膜式氧合器可以代替胎盘气体交换功能,体外循环中胎羊生理低水平PO2是否适合其需要值得探讨.

    Release date:2016-08-30 06:32 Export PDF Favorites Scan
  • Cryopreserved Homograft Pericardium Patch in Staged Repair of Tetralogy of Fallot

    Objective To compare the difference of effect while using homograft pericardium patch and Gore- tex patch in staged repair of tetralogy of Fallot(TOF) to enlarge the right ventricular outflow tract (RVOT). Methods Twenty-eight patients with TOF who underwent the staged complete repair were divided into 2 groups according to the date of surgery. Gore-rex group, 13 cases, their RVOT were enlarged with Gore-tex patches. Cryopreserved homograft pericardium patch group, 15 cases, their RVOT were enlarged with cryopreserved homograft pericardium patches. Clinical results and follow-up results were compared. Results There were 1 operative death in Gore-tex patch group (7. 7%), and 1 early postoperative death in cryopreserved homograft pericardium patch group (6. 7%). Hemostasia time, the pericardial cavity drainage volume in cryopreserved homograft pericardium patch group were less than those in Gore-tex patch group (P〈0. 01). All patients were followed-up for 0.8-4.5years. The residual obstruction rate at RVOT level in Gore-tex patch group was higher than that in cryopreserved homograft pericardium patch group by echocardiography (P〈0.01). No calcification shadow was found on the chest X-ray. Conclusion Homograft pericardium is the tissue with high density and intensity, its elasticity and compliance are good. Using homograft pericardium patch may be helpful to decrease the residual obstruction of RVOT after operation. It can be adapted as a repairing material in heart surgery.

    Release date:2016-08-30 06:26 Export PDF Favorites Scan
  • Investigation on the Examinees' Cognitive Level of X-ray Radiation

    ObjectiveTo study the examinees' cognitive level of the X-ray radiation, and to provide references for popularizing radiation protection knowledge. MethodWe chose patients who were checked in the Department of Radiology in our hospital between August 30 and October 29, 2013 as our study subjects, and carried out investigation by anonymous questionnaires. The investigation content included the respondents' basic information, ways to obtain the radiation knowledge, how well the patients knew about the fundamental radiation knowledge and their attitudes towards radiological examination and so on. A total of 2 315 patients were investigated, and 2 315 questionnaires were issued. Finally all questionnaires were retreated. ResultsAmong the 2 315 patients, 2026 (87.52%) knew the radiation symbol and 1 821 (78.66%) knew that X-ray radiation was harmful to the human body. Different age, gender, occupation, educational level and previous X-ray examination made significant differences in the fundamental knowledge on X-ray (P<0.05) . Attitudes towards X-ray examination was significantly different due to different age, occupation, and educational level (P<0.05) . Most examinees got the X-ray fundamental radiation knowledge from the publicity and medical staff in hospitals. ConclusionsTo make the examinees keep right attitudes and behaviors in radiographic examination, further effective methods of popularizing the basic knowledge of radiation should be carried out. Those publicity and medical staff in hospitals are the main force in the popularization of radiation knowledge.

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  • L-精氨酸对乳猪深低温停循环脑代谢与结构的影响

    目的 通过深低温停循环(DHCA)转流模型,研究左旋精氨酸(L-arg)在低温缺血时对脑代谢和结构的影响. 方法 采用上海种白猪,3~4周龄,随机均分成4组: L-arg组,左旋硝基精氨酸甲酯(L-NAME)组, L-arg+L-NAME组和对照组,每组10只.按临床方法行心肺转流术,于转流前、降温末、复温末和转流结束等分别测定颈内静脉一氧化氮(NO)、脑皮质三磷酸腺苷(ATP)和颈内静脉乳酸含量.并行脑组织学和超微结构观察. 结果 降温末L-NAME组和对照组NO含量较其它两组明显下降(Plt;0.01).复温末,除L-NAME组外,其余3组均恢复至转流前水平(Plt;0.01),L-arg组NO水平在复温末较转流前高(Plt;0.01). 转流开始后大脑皮质ATP即有明显下降,L-arg组下降幅度最小,且在复温末已接近转流前水平;L-NAME组下降幅度最大(Plt;0.01). 转流开始后颈内静脉乳酸含量即升高,L-arg组和L-arg+L-NAME组上升幅度较小;降温末和转流结束乳酸含量较其它两组低(Plt;0.01). 大脑皮质组织学和超微结构检查显示,大脑皮质细胞结构变化L-arg组和L-arg+L-NAME组较对照组和L-NAME组轻. 结论 深低温停循环手术时,应用L-arg具有较好的脑保护作用,而L-NAME有脑损害作用.L-arg可部分逆转DHCA时L-NAME对脑组织的损害作用.

    Release date:2016-08-30 06:32 Export PDF Favorites Scan
  • Single Stage Repair of Interrupted Aortic Arch with Associated Cardiac Anomalies

    Abstract:Objective To summarize the experiences of single stage repair of interrupted aortic arch (IAA) associated with cardiac anomalies. Methods From Jan. 2000 to Dec. 2005, 48 patients admited in hospital and 35 patients were operated, the mean age at operation was 1.1 years. The associated anomalies included 23 cases of ventricular septal defect, 2 cases of transposition of great arteries, 3 cases of aortopulmonary window with aortic origin of right pulmonary artery, 2 cases of truncus arteriosus, 2 cases of double outlet right ventricle, 2 cases of stenotic fifth arch and 1 case of aberrant origin of right subclavian artery with mild hypoplastic decending aorta. Among them, 34 patients underwent single stage repair and 1 kid underwent palliative correction. Results There were 4 surgical deaths. The sequelae included one diaphragm paralysis and one 3rd degree of atrioventricular block. Only 5 kids recurred mild stenosis of aortic arch anastomosis and 2 death occurred during 3 months to 4 years of follow-up. Conclusion Though early surgical mortality for primary single stage repair is now relatively low, if appropriate interventions has been accomplished during perioperative period, but outcomes of IAA remain of concern, especially in patients with associated lesions.

    Release date:2016-08-30 06:23 Export PDF Favorites Scan
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