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find Author "张爱平" 5 results
  • Advance of Differential Diagnosis between Benign and Malignant Solitary Pulmonary Nodule

    Diagnosis and treatment of solitary pulmonary nodule (SPN, less than 30 mm in diameter) has been a formidable problem in clinical work. It is often detected in medical examination or other disease examinations by chance. There are no corresponding signs and symptoms of SPN except those on the imaging, so it is difficult to make a correct diagnosis as early as possible. Literature shows that there is a certain probability of malignant SPN, so early correct diagnosis is the key factor in deciding the prognosis and appropriate treatment. With the accumulation of clinical experiences, the development of new fiberoptic bronchoscopy, highresolution CT, and videoassisted thoracoscopic surgery, as well as the evolution of some invasive examination technologies, it is less difficult in distinguishing benign from malignant SPN than ever before. In this article, we will make a comprehensive review on the development in the aspect of differential diagnosis of SPN.

    Release date:2016-08-30 05:56 Export PDF Favorites Scan
  • 电视胸腔镜双侧肺减容术21例

    目的 总结电视胸腔镜双侧肺减容术(BLVRS)治疗慢性阻塞性肺气肿(COPE)的临床经验,并观察其疗效。 方法 2009年9月至2010年9月,南京医科大学附属南京医院对21例COPE患者行电视胸腔镜 BLVRS,均为男性,年龄(65.71±9.05)岁。采用电视胸腔镜专用切缝器(Endo-GIA)切除过度充气的肺大泡组织,常规用4-0 Prolene线连续往返缝合。术后观察患者的肺功能、血气分析指标和6 min步行距离(6-MWD)的变化,并与术前进行比较,评价手术疗效。 结果 无围术期死亡,术后住院时间(13.20±4.60) d,胸腔引流时间(5.33±3.67) d。术后持续肺漏气 (5.91±3.52) d 12例,出现急性呼吸衰竭1例,广泛皮下气肿2例,合并肺部感染5例,均经相应的处理治愈。随访21例,随访时间6个月,术后6个月第1秒用力呼气容积[(1.63±0.23) L vs. (1.21±0.17) L]、动脉血氧分压[(77.62±6.98) mm Hg vs. (67.54±8.12) mm Hg]和6-MWD [(430.55±80.49) m vs. (283.48±108.12) m]较术前增加,动脉血二氧化碳分压(PaCO2)、、残气量(RV) 较术前降低(P<0.05)。 结论 电视胸腔镜BLVRS安全、有效,特别对非均质性肺气肿,可明显改善患者的生活质量,近期效果显著。

    Release date:2016-08-30 05:50 Export PDF Favorites Scan
  • The Correlation of Integrinlinked Kinase and Matrix Metalloproteinases9 Expression with Prognosis of Nonsmall Cell Lung Cancer

     Abstract: Objective To observe the expression of integrinlinked kinase (ILK) and matrix metalloproteinases9 (MMP9) in human nonsmall cell lung cancer (NSCLC) and investigate the correlation of ILK and MMP9 expression with the prognosis of NSCLC. Methods The expression of ILK and MMP9 in 75 specimens of NSCLC resected from January 2002 to January 2004 were detected by immunohistochemistry. According to the median of integral optical density (IOD), all patients were divided into the high or low ILK expression group and the high or low MMP-9 expression group. The relativity of ILK and MMP9 was determined, and the relationship of survival time with clinical features including expression of ILK and MMP-9 was compared by Logrank test. Results Both ILK and MMP-9 were expressed in NSCLC specimens. The expression between ILK and MMP-9 was positively correlated in 75 patients of our group (r=0.79, Plt;0.05). Patients with lower expression of ILK and MMP9 had a significantly longer survival time than those with higher expression of ILK and MMP-9 in the postoperative followup (χ2=15.067,14301,Plt;0.05). The survival time was not correlated with sex,age,smoking history or pathological type(χ2=0450,0078, 1.460, 1.623,Pgt;0.05), while tumor diameter, lymph node metastasis, TNM stage, the expression of ILK and MMP-9 significantly influenced the survival time (χ2=3.963, 15.169,20.529, 15.067,14.301,Plt;0.05). Conclusion  The expression of ILK and MMP9 affects the prognosis of NSCLC. MMP-9 may advance infiltration and metastasis of tumor cells through ILK pathway. In summary, the expression of ILK and MMP9 may play an important role in the evaluation of prognosis for patients with NSCLC.

    Release date:2016-08-30 06:03 Export PDF Favorites Scan
  • 纵隔后巨大脂肪瘤一例

    Release date:2016-08-30 06:02 Export PDF Favorites Scan
  • 支气管内膜结核致肺不张外科治疗28例

    Release date:2016-08-30 06:08 Export PDF Favorites Scan
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