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find Author "张重阳" 2 results
  • Synergistic drug combination prediction in multi-input neural network

    Synergistic effects of drug combinations are very important in improving drug efficacy or reducing drug toxicity. However, due to the complex mechanism of action between drugs, it is expensive to screen new drug combinations through trials. It is well known that virtual screening of computational models can effectively reduce the test cost. Recently, foreign scholars successfully predicted the synergistic value of new drug combinations on cancer cell lines by using deep learning model DeepSynergy. However, DeepSynergy is a two-stage method and uses only one kind of feature as input. In this study, we proposed a new end-to-end deep learning model, MulinputSynergy which predicted the synergistic value of drug combinations by integrating gene expression, gene mutation, gene copy number characteristics of cancer cells and anticancer drug chemistry characteristics. In order to solve the problem of high dimension of features, we used convolutional neural network to reduce the dimension of gene features. Experimental results showed that the proposed model was superior to DeepSynergy deep learning model, with the mean square error decreasing from 197 to 176, the mean absolute error decreasing from 9.48 to 8.77, and the decision coefficient increasing from 0.53 to 0.58. This model could learn the potential relationship between anticancer drugs and cell lines from a variety of characteristics and locate the effective drug combinations quickly and accurately.

    Release date:2020-10-20 05:56 Export PDF Favorites Scan
  • 三维矫形内固定治疗成人特发性脊柱侧凸

    目的 探讨成人特发性脊柱侧凸的治疗方法及临床效果。方法 2003年2月~2005年11月,采用脊柱三维矫形技术治疗特发性脊柱侧凸12例,男4例,女8例;年龄21~35岁。其中腰弯5例,Cobb角46~65°;长胸弯4例,Cobb角85~102°;胸腰弯3例,Cobb角96~108°。以疼痛为主要症状8例,以畸形为主要症状4例。无明显神经症状。术前常规摄X线片,均有冠状面上的脊柱侧凸及椎体的旋转,矢状面上的胸腰椎生理曲度的异常改变,MRI检查均无明显的脊柱脊髓异常表现。结果 12例术后均无神经损伤及并发症出现。5例腰弯患者Cobb角4~15°,平均纠正率84.7%;矢状面曲度25~40°;身高增长2~4 cm。4例长胸弯患者Cobb角28~43°,平均纠正率60.8%;3例胸腰弯患者Cobb角25~34°,平均纠正率71.3%。长胸弯及胸腰弯患者矢状面上交界性后凸全部纠正至正常,胸椎后凸及腰椎前凸均在正常范围之内,增长身高5.0~8.5 cm,平均6.6 cm。12例获随访7~31个月,均无断钉、断棒、脱钩、脱钉等现象及假关节形成,1年以上复查患者全部骨性融合,纠正丢失5%。结论 三维矫形内固定治疗特发性脊柱侧凸,重建躯干平衡,效果满意,术中应用体感诱发电位监护及唤醒试验预防神经并发症的发生。

    Release date:2016-09-01 09:23 Export PDF Favorites Scan
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