目的 探讨腹腔镜结肠癌根治术的临床效果。方法 应用腹腔镜外科技术对25例结肠癌患者实施腹腔镜结肠癌根治术。结果 本组25例手术时间110～310 min，平均195 min； 术中出血量约100～350 ml，平均约180 ml； 术后胃肠功能恢复时间1～4 d，平均 1.7 d。所有标本残端无肿瘤细胞残留、浸润。所有病例术后未出现出血、吻合口漏和狭窄并发症，仅有2例出现伤口感染。术后住院6～10 d，平均7.5 d； 术后19例随访2～38个月，平均13个月，其中2例于手术后第12个月和14个月因肿瘤广泛转移、衰竭而死亡； 余17例随访期间均未发现有转移复发及切口种植。结论 腹腔镜结肠癌根治术具有微创、安全、术后恢复快、肿瘤根治彻底等优点，值得临床推广应用。
ObjectiveTo summarize the blood routine indexes and predictive systems that can predict the severity of acute pancreatitis (AP). MethodThe recent domestic and foreign literatures on the predictive value of blood routine indexes for the severity of AP were reviewed.ResultsFrom the current research results at domestic and foreign, independent blood routine indexes such as red blood cell distribution width, average platelet volume, hematocrit (TCT), platelet (PLT) count, platelet distribution width, percentage of immature granulocytes (IG%), and some blood routine calculation indexes such as neutrophil to lymphocyte ratio (NLR), PLT to lymphocyte ratio (PLR), red blood cell distribution width to PLT ratio (RPR), neutrophil-monocyte product, and so on, all had different predictive value for the severity of AP. In addition, multiple prediction modes such as blood routine indexes combined with some serological indexes or other scoring systems could also be used to predict the severity of AP. In general, the predictive value of the NLR, IG%, and HCT on the severity of AP had been unanimously recognized by researchers. However, the conclusions of related studies on the predictive values of PLT, PLR, and RPR on the severity of AP were still controversial. ConclusionsAt present, there are a variety of blood routine indexes can be used to predict severity of AP, but their predictive values are different. Further researches are still needed.
ObjectiveTo investigate the regulation mechanism of neutrophils extracellular traps (NETs) on inflammatory diseases and to provide guidance for the treatment of related inflammatory diseases.MethodThe literatures about the relationship between NETs and inflammatory diseases were reviewed.ResultsNETs played an important role in sepsis, anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, acute pancreatitis, inflammatory bowel disease, and other inflammatory diseases, which were related to the development or activity of the diseases. By regulating the formation of NETs pathway, reducing the production of NETs, we could ultimately reduce the inflammation of the disease.ConclusionNETs is involved in the course of sepsis, ANCA-associated vasculitis, acute pancreatitis, inflammatory bowel disease, and other inflammatory diseases, but further investigation and clinical inflammatory verification are needed.