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find Keyword "手足口病" 13 results
  • Clinical Efficacy on Tanreqing Injection for Curing Hand-Foot-Mouth Disease: A Meta-Analysis

    Objective To systematically review the effectiveness and safety of Tanreqing for curing the hand-foot-mouth disease. Methods Such databases as PubMed, EMbase, CENTRAL, CBM, CNKI, VIP and WanFang Data are electronically searched to collect the randomized controlled trials (RCTs) on the effectiveness and safety of Tanreqing for hand-foot-mouth disease till February 2013. According to the inclusion and exclusion criteria, literature was screened, data were extracted, and the methodological quality of included studies was also assessed. Then, meta-analysis was performed using RevMan 5.2.7 software. Results Twelve RCTs on Tanreqing versus ribavirin involving 1 258 cases and 27 RCTs on Tanreqing plus ribavirin versus ribavirin involving 3 289 cases were included. The results of meta-analysis showed that, compared to ribavirin, Tanreqing has higher total efficiency in the treatment of hand-foot-mouth disease (OR=5.03, 95%CI 3.28 to 7.71, Plt;0.000 01), cooling time (MD= –1.09, 95%CI –1.51 to –0.68, Plt;0.000 01), simplex regression time (MD= –0.90, 95%CI –1.20 to –0.60, Plt;0.000 01), and healing time (MD= –1.76, 95%CI –2.52 to –0.99, Plt;0.000 01), with significant differences. Compared to ribavirin, the group of Tanreqing plus ribavirin has higher total efficiency on treatment of hand-foot-mouth disease (OR=5.32, 95%CI 4.02 to 7.06, Plt;0.000 01), cooling time (MD= –1.32, 95%CI –1.63 to –1.01, Plt;0.000 01), simplex regression time (MD= –0.5, 95%CI –0.98 to –0.2, Plt;0.000 01), and healing time (MD= –1.41, 95%CI –1.83 to –0.98, Plt;0.000 01), with significant differences. The results of indirect comparative analysis showed that, there was no significant difference in the treatment options of Tanreqing plus ribavirin and Tanreqing alone concerning total efficiency, cooling time, simplex regression time, and healing time. Conclusion The study shows that Tanreqing alone and Tanreqing plus ribavirin are similar for curing the hand-foot-mouth disease, and both groups have better clinical effectiveness than ribavirin alone.

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  • Therapeutic and Nursing Effect on Hand-foot-mouth Disease with Infection after Medication for External Use

    【摘要】 目的 对住院的手足口病患儿,在相同治疗和护理基础上,应用复方黄连素片剂融入复方炉甘石洗剂外用观察其疗效和安全性,为传染病的防制提供临床经验。 方法 2008年5月-2010年5月收治手足口病患儿184例,采用随机分组法,以复方黄连素片剂融入复方炉甘石洗剂外用92例为治疗组,未用复方黄连素片剂融入复方炉甘石洗剂外用92例为对照组,进行疗效比较。 结果 治疗组5 d痊愈率为94%,总有效率为100%,与对照组比较差异有统计学意义(Plt;0.01)。 结论 应用复方黄连素片剂融入复方炉甘石洗剂外用治疗手足口病安全可靠。【Abstract】 Objective To observe the therapeutic and nursing effect on hand-foot-mouth disease (HFMD) with infection after medication for external use. Methods A total of 184 patients with HFMD from May 2008 to May 2010 were randomly divided into two groups: 92 patients in the treatment group underwent medication for the external use topical with berberine tablet blending in calamine lotion for, and another 92 patients in the control group didn’t undergone the medication for the external use. Results The total cure rate within 5 days in treatment group was 94% and the total effective rate was 100%, which was significantly different from that in the control group (Plt;0.01). Conclusion Berberine tablet blending in calamine lotion application is safe and effective on patients with HFMD with infection.

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  • Etiology and Clinical Characteristics of 482 Children with Hand-Foot-Mouth Disease

    Objective To investigate the etiological and clinical characteristics of the outbreak of hand-foot-mouth disease (HFMD) in Chengdu in 2008. Methods A retrospective analysis was conducted to investigate 482 children with hand-foot-mouth disease in Chengdu from January to December 2008 in terms of epidemiology and clinical characteristics. Results Among the 482 children, 76.14% of the cases were infants, and male children numbered more than female ones. The proportion in the urban area was higher than that in the rural area. May to July was the peak epidemic period. Skin rash and fever were major clinical manifestations. Three cases were diagnosed as viral encephalitis. Conclusion The incidence of hand-foot-mouth disease is related to age and season. Effective prevention measures and isolated treatment are critical for prevention and therapy.

    Release date:2016-09-07 02:10 Export PDF Favorites Scan
  • Clinical Analysis of 31 Children with Hand-Foot-Mouth Disease

    Objective To share the experience of the diagnosis and treatment of children with hand-foot-mouth disease. Methods We retrospectively analyzed 31 children with hand-foot-mouth disease in our hospital from April 2007 to June 2007 in terms of epidemiology, clinical features, treatment and prognosis. Results The average age of the children was 2.8 years, and 20 out of the 31 cases were from nurseries and kindergartens. Eighteen had clear contact history. Typical signs and symptoms, including oral ulcerative herpes and blister-like rash in extremities, were found in all cases. All the children were cured after timely diagnosis and early treatment with ribavirin, without any severe complications. Conclusion Timely treatment based on early diagnosis and considerate care are important for children with hand-foot-mouth disease. Nurseries, kindergartens and primary schools should attach great importance to relevant prophylaxis and isolation. These are essential for reducing the occurrence and prevalence of this disease.

    Release date:2016-09-07 02:12 Export PDF Favorites Scan
  • 金莲清热泡腾片联合利巴韦林治疗手足口病的疗效分析

    目的 观察中西医结合治疗手足口病的临床疗效。 方法 将2009年12月-2011年8月符合标准的60例患儿采用随机数字方法分为对照组和治疗组,每组各30例。对照组采用利巴韦林等药物对症支持治疗,治疗组在此基础上加用金莲清热泡腾片。疗效参考国家中医药管理局发布的《中医病证诊断疗效标准》制定;嘱门诊复查。 结果 治疗后治疗组患儿退热时间、口腔溃疡愈合时间、皮疹完全消失时间和总疗程均缩短,与对照组相比,差异有统计学意义(P<0.05)。 结论 中西医综合治疗手足口病疗效确切,值得临床推广。

    Release date:2016-09-08 09:12 Export PDF Favorites Scan
  • Bundle Care for Children with Severe Hand-foot-mouth Disease

    目的 探讨危重症手足口病的集束化综合救护的护理方案。 方法 通过比较儿科使用集束化综合护理方案后1年(2009年5月-2010年4月)的26例危重症手足口病并发症的发生率,确定预防危重症手足口病的集束化综合护理方案的有效性。 结果 使用集束化综合护理方案后,26例患儿均治愈出院,其中仅3例有后遗症。 结论 集束化综合护理救治作为主动预防措施比传统的被动预防更有针对性和有效。

    Release date:2016-09-08 09:13 Export PDF Favorites Scan
  • 手足口病患儿护理体会

    【摘要】 目的 总结患儿手足口病的护理要点。 方法 2010年1月—2010年6月对收治387例手足口病患儿的护理资料进行回顾性分析,针对患儿特点及疾病的传染性,除及时采取消毒隔离外,重点对其皮肤、口腔、发热、心理、进行特别护理。 结果 经精心治疗与护理,385例患儿的病情得到有效控制并治愈出院。 结论 积极有效的护理措施是患儿手足口病得以控制和治愈的重要因素。

    Release date:2016-09-08 09:26 Export PDF Favorites Scan
  • Observation on the Curative Effects of Xiyanping united with Interferon to Therapy the Hand Foot and Mouth Disease

    目的:目的:观察喜炎平联合干扰素治疗手足口病的临床疗效。 方法:将180例手足口病患儿随机分为治疗组和对照组,每组90例。治疗组喜炎平联合干扰素治疗:静滴喜炎平10 ㎎/㎏.d,干扰素剂量为5万u/㎏.d,皮下注射,疗程7天;对照组以干扰素剂量为5万u/㎏.d,皮下注射,疗程7天。结果:治疗组总有效率为88.9 %,对照组总有效率为76.7 %(P<0.05),治疗组临床症状及体征明显较对照组消失早(P<0.05)。 结论:喜炎平联合干扰素治疗手足口病疗效佳,值得临床推广应用。

    Release date:2016-09-08 10:00 Export PDF Favorites Scan
  • Research on the Health Educational Status of Parents of Children with Hand, Foot and Mouth Disease and Its Influence Factors

    ObjectiveTo observe the effect of health education on hand, foot and mouth disease knowledge of the parents and their psychological status, in order to provide a reference for regulating clinical intervention measures. MethodsBetween October 2011 and February 2013, self-made questionnaire was used to survey the parents of 286 children with hand, foot and mouth disease for their knowledge about the disease. We promoted health education including distributing pamphlets, holding lectures, and carrying out psychological counseling. Then, parents' knowledge and their psychological status were compared before and after the implementation of health education. ResultsAfter health education, parents' suspicion, anxiety, fear, indulgence in children and other negative psychological scores were significantly lower than those before intervention (P<0.05). Their knowledge on the disease was also significantly enhanced (P<0.05). Gender, age and educational background were the main influence factors for health education. ConclusionMulti-form comprehensive health education can enhance parents' knowledge on hand, foot and mouth disease effectively and alleviate various negative psychological situations, which assists them to participate in the treatment work actively, thus greatly promotes early rehabilitation of the child patients.

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  • Comparative Research between Fluorogenic Quantitative Polymerase Chain Reaction and Enzyme-linked Immunosorbent Assay Applied in Diagnosing Enterovirus 71 Infection

    ObjectiveTo compare effect of enterovirus (EV) 71 nucleic acid detection and EV71-IgM antibody detection on clinically diagnosis of hand-foot-mouth disease in children. MethodsRectal swabs collected from 1379 children who were clinically diagnosed from April 20, 2011 to September 10, 2011 as suspected patients with the handfoot- mouth disease were detected by fluorogenic quantitative polymerase chain reaction to conduct EV71 nucleic acid detection. Meantime, enzyme-linked immunosorbent assay was used to conduct EV71-IgM antibody detection in serum samples collected from those children. ResultsIn these 1379 cases, 79 had positive EV71 nucleic acids with a positive rate of 5.73%; while 82 cases had positive EV71-IgM antibodies with a positive rate of 5.95%. There were 32 cases with positive EV71 nucleic acid and positive EV71-IgM antibody. The rate of consistent results of two detection methods was 95.2%. The positive rates of two methods had no negligible differences (χ2=0.093, P=0.761). ConclusionCombination of EV71 nucleic acid detection and EV71-IgM antibody detection, can improve the efficiency in diagnosing hand-foot-mouth disease in children and facilitate the protection and diagnosis of the disease.

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