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find Keyword "抗核小体抗体" 2 results
  • Diagnostic Value of Anti-nucleosome Antibody in SLE Patients: A Systematic Review

    Objective To evaluate the diagnostic value of anti-nucleosome antibody (AnuA) in patients with systemic lupus erythematosus (SLE). Methods We searched MEDLINE, EMbase and The Cochrane Library to identify studies on the diagnostic value of AnuA in patients with SLE. The searching time was from 1990 to 2005. The quality of included studies was evaluated and the data were extracted. The Cochrane Collaboration’s RevMan software was used to analyze heterogeneity, and MetaDisc was used to perform meta-analyses and draw summary receiver operator characteristic curve (SROC). Results Twenty-five studies involving 7 289 patients (2 459 SLE and 5 030 non-SLE patients were diagnosed by gold standard) were included, most of which were poor in quality. The heterogeneity among studies was high (Plt;0.000 01, I2=87.2%). The pooled sensitivity was 64.9%, 95% CI 63.0 to 66.85, and the pooled specificity was 92.6%, 95% CI 91.8% to 93.3%. Area under the SROC was 0.918, SE0.0212. These data suggested that AnuA had a relatively high false negative rate (35.1%) and a relatively low false positive rate (7.4%). Conclusions AnuA has some value in diagnosing SLE and could possibly be used as one of the diagnostic tests for SLE.

    Release date:2016-09-07 02:15 Export PDF Favorites Scan
  • 三种自身抗体和补体C3水平检测对狼疮性肾炎患者的诊断意义

    目的探讨抗心磷脂抗体(ACA)、抗核小体抗体、抗核糖体p蛋白抗体3种自身抗体与补体C3水平检测对狼疮性肾炎(LN)患者的诊断意义。 方法2005年7月-2010年12月对406例系统性红斑狼疮(SLE)患者(其中LN 122例)和120例健康体检者采用酶联免疫吸附测定法测定ACA,应用欧蒙印迹法测定抗核小体抗体和抗核糖体p蛋白抗体,应用散射比浊法测定补体C3水平。 结果ACA和抗核糖体p蛋白抗体阳性率在LN组均为21.31%,在非LN组分别为17.61%、14.08%,差异无统计学意义(P>0.05);抗核小体抗体在LN组为56.56%,在非LN组为39.08%,差异有统计学意义(P<0.05);LN组和非LN组3种抗体阳性率与对照组比较差异有统计学意义(P<0.01);LN组、非LN组和对照组补体C3水平分别为(0.52±0.22)、(0.67±0.29)、(1.28±0.32)g/L,3组比较差异均有统计学意义(P<0.01);LN组ACA、抗核小体抗体和抗核糖体p蛋白抗体同时阳性率(10.66%)高于非LN组(3.17%),差异有统计学意义(P<0.05)。 结论ACA、抗核小体抗体、抗核糖体p蛋白抗体及补体C3的联合检测对狼疮性肾炎的诊断及鉴别诊断、预后判断等方面具有一定意义。

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