Objective To evaluate the quality of diagnostic studies on detecting anti-cyclic citrullonated peptide antibody to diagnose rheumatoid arthritis. Methods We searched PubMed, EMbase, The Cochrane Library, and CBM to collect studies on using anti-cyclic citrullonated peptide antibody to diagnose rheumatoid arthritis. QUADAS items were used to evaluate the quality of included studies. Results A total of 195 studies were included. Sixty-nine were English studies and 126 were Chinese studies. All studies had good descriptions of the spectrum of patients and little potential for partial verification bias, differential verification bias, and incorporation bias. However, most studies were prone to disease progression bias, review bias, and clinical review bias. One study did not explain the intermediate test results, and another did not report part of the test results. The overall quality of English studies was better than that of Chinese studies. Conclusion The potential bias of the included studies mainly resulted from the absence of blinding when interpreting the test results. The reporting quality of the included studies was poor.
目的 探讨抗环瓜氨酸肽抗体（anti-CCP）与类风湿因子（RF）对类风湿关节炎（RA）的诊断效能，及RF分型检测在RA活动度判断中的价值。 方法 选取2012年3月－2013年2月就诊的64例RA患者为病例组，103例其他自身免疫性疾病患者为对照组，用酶联免疫吸附试验分别检测anti-CCP和RF-IgM/IgG/IgA，收集数据进行统计分析。 结果 anti-CCP与RF联合指标对RA的诊断灵敏度最高（92.2%），anti-CCP的特异度最高（95.1%）；RF-IgA的水平与骨关节侵蚀程度呈正相关（rs=0.987，P=0.000）；RF的3个亚型都可反映RA疾病的活动度（P＜0.05）。 结论 anti-CCP与RF联合诊断RA，可显著提高诊断灵敏度，RF的分型检测对于RA患者的活动度监测有重要价值。