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find Keyword "损伤/并发症" 7 results
  • 应用液压冲击颅脑损伤仪建立大鼠外伤性视神经损伤动物模型

    Objective To observe whether the animal model of optic nerve injury in rats can be set up by fluid percussion brain injury device (FPI) or not.Methods Seventyone healthy female Wister rats were randomly divided into 2 groups, inlcuding model group with 66 rats and control group with 5 rats.The rats in model group were randomly divided into 3 groups. Eight rats in group 1 were examined by flashvisual evoked potential (F-VEP) and magnetic resonance imaging (MRI) examines before and 1, 3 days,1,2,4,6,and 8 weeks after injury; 56 rats in group 2 were randomly divided into 7 subgroups with 8 rats in each subgroup,and were detected by histopathological and terminal deoxynucleotidyl transferasemediated dUTP nick end labeling (TUNEL) apoptosis examines 1, 3 days, 1,2,4,6,8 weeks after injury;2 rats in group 3 were examined by electron microscopy 4 and 8 weeks after injury.According to the degree of injury, the injured eyes were divided into 2 groups including severe injury group with the beat pressure of (699.14plusmn;60.79) kPa and mild injury group with the beat pressure of (243.18plusmn;20.26) kPa.The right and left eyes in rats in each group were in severe and mild injury group, respectively.Results One day after injury, the latency duration of FVEP prolonged in severe injury group,wich differed much form which in the normal control group (P<0.05);the amplitude was gradually reduced during the first 2 weeks after injury and kept steady after that (P>0.05). The latency duration prolonged in mild injury group,and its difference with the normal control group was statistically significant (P<0.05);the amplitude was gradually reduced during the first 4 weeks after injury and kept steady after that (P>0.05). The abnormal high signal could be seen on optic nerve 1 day after injury, and was still obvious 8 weeks later. The results of histopathological examination showed ruptured capillary in ganglion cell layer 1 day after injury;retinal ganglion cells without nucleus could be seen 4 weeks after injury. The apoptosis of positive cells was found in each layer of the retina 3 days after injury.TUNEL results indicated that the number of apoptotic positive cells increased significantly 1-2 weeks after injury.Conclusion An animal model of optic nerve injury can be successfully set up using FPI in rats.

    Release date:2016-09-02 05:42 Export PDF Favorites Scan
  • 车祸致头部多发伤表现出远达性视网膜病变一例

    Release date:2016-09-02 05:46 Export PDF Favorites Scan
  • 硅油在外伤性视网膜脱离治疗中的应用

    Release date:2016-09-02 06:03 Export PDF Favorites Scan
  • 玻璃体积血144例病因分析

    Release date:2016-09-02 06:07 Export PDF Favorites Scan
  • Terson 综合征三例

    Release date:2016-09-02 06:07 Export PDF Favorites Scan
  • 58例儿童裂孔性视网膜脱离发病因素分析

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  • 颅脑外伤导致的非典型性八个半综合征一例

    Release date:2017-09-19 03:09 Export PDF Favorites Scan
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