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find Author "曹小平" 5 results
  • Analysis of First Symptoms and Emergency Diagnosis of Aortic Dissection

    目的 认识主动脉夹层患者的急诊症状,减少漏诊与误诊。 方法 对2006年1月-2012年7月21例急性主动脉夹层患者的首发症状、辅助检查、临床诊断进行回顾性分析,总结误诊的原因。 结果 首发症状为剧烈胸痛和(或)腹痛15例(71.4%),胸闷、呼吸困难4例(19.0%),胸痛伴肢体偏瘫1例(4.8%),无痛性晕厥1例(4.8%)。15例行心电图检查,10例(66.7%)异常;17例行急诊胸部X线片检查,7例(41.2%)异常;9例行急诊增强螺旋CT检察,均发现真假两腔(100.0%);10例行急诊超声心动图检查,8例(80.0%)见假腔形成;15例行心肌梗死3项(肌酸激酶同工酶、肌红蛋白、肌钙蛋白I)检查,4例(26.7%)异常;12例行D-二聚体检查,3例(25.0%)异常。15例急诊拟诊主动脉夹层,6例误诊为其他疾病。 结论 主动脉夹层临床表现复杂,提高认识及必要的辅助检查有助于早期诊断。

    Release date:2016-09-07 02:38 Export PDF Favorites Scan
  • Experiment on Acute Lung Injury in Sprague-Dawley Rats Induced by Organophosphorus Pesticide

    ObjectiveTo explore the mechanism of lung injury in Sprague-Dawley (SD) rats induced by acute organic phosphorus pesticides (AOPP) by observing the changes of the blood serum nuclear factor (NF)-κB consistence, NF-κB level of lung tissue and lung coefficient. MethodNinety-six healthy male SD rats (six weeks old) were randomly divided into group A (control, n=48) and group B (poison, n=48). The rats of group B were given omethoate by gavage (45 mg/kg), and the rats of group A accepted normal saline. Then the rats were killed at designated observing points (30 minutes; 3, 6, 12, 24, and 48 hours), and the lung coefficient, blood serum NF-κB consistence and NF-κB level of lung tissue were measured. At the same time, we observed the pathological changes of the rats' lung tissue. ResultsCompared with group A, blood serum NF-κB consistence, NF-κB level of lung tissue and the level of lung coefficient in group B were significantly higher (P<0.01). The lung tissues of group A were normal at each time point, but in group B, the lung pathological changes gradually appeared 30 minutes later with pulmonary interstitial engorging, alveolar septum widening and some alveolus being full of red blood cells, and this situation reached its peak at hour 12. Then it gradually mitigated from 24 to 48 hours. ConclusionThere are significant increases in blood serum NF-κB consistence and NF-κB level in lung tissues in rats with lung injury induced by omethoate poisoning. The NF-κB may play a role in the process of lung injury induced by organophosphorus pesticide.

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  • Research progress of anti-inflammatory cytokines in sepsis

    Sepsis is a worldwide problem. Although there are many related researchs and animal experiments about sepsis, the mortality of sepsis is still high. In the early stage of sepsis, after the pathogenic bacteria invade the body, the immune response produced by the body promotes the synthesis and secretion of a series of cytokines. Among them, there are proinflammatory cytokines that promote inflammatory response and anti-inflammatory cytokines that inhibit inflammatory response. These cytokines interact with each other and maintain a dynamic balance in complex cell grid. This is to restore the steady state of the body after resisting and eliminating the invaders.Anti-inflammatory cytokines play an important role in it. They act on specific immune cells or immune regulatory receptors. Anti-inflammatory cytokines limit persistent or excessive inflammatory responses after killing invaders, and reduce or block pro-inflammatory cytokine activities. These anti-inflammatory cytokines also can heal body to restore the normal immune physiological level of the organism. This article will review the related research of anti-inflammatory cytokines in sepsis.

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  • 非临床医学专业学生的《临床医学概要》教学方法探讨

    【摘要】 目的 对目前“临床医学概要”的教学方法进行改进。 方法 从提高教师自身素质、优化课程内容、合理应用多媒体教学、改进教学方法和手段、调动学生的学习主动性和积极性、加强沟通和改变考核方式等七个方面入手,对如何改善“临床医学概要”的教学状况进行了探讨。 结果 改进后的教学方法在“临床医学概要”的教学中效果甚佳,很好地实现了本课程的教学目的,且做到了教学相长。 结论 该教学方法的改进在“临床医学概要”的教学中切实可行,收效甚佳,值得推广。

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  • Pathogenesis and treatment of septic cardiomyopathy

    Sepsis is a common complication after severe trauma, infection, shock and major surgery. It has the characteristics of high morbidity, high mortality, and high hospitalization costs. Septic cardiomyopathy is one of the main causes of death in patients with sepsis. This article reviews the pathogenesis and treatment of septic cardiomyopathy. The pathogenesis includes hemodynamics and myocardial changes, mitochondrial fission, cardiomyocyte apoptosis and autophagy, calcium ion imbalance, inflammation mechanism and immune regulation mechanism. The treatment includes conventional treatment, β1 receptor blocker treatment, melatonin, serotonin 3 receptor antagonist, dexmedetomidine and traditional Chinese medicine treatment, etc., aiming to provide a reference for the diagnosis and treatment of septic cardiomyopathy.

    Release date:2020-12-28 09:30 Export PDF Favorites Scan
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