west china medical publishers
Author
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Author "曾兴颖" 3 results
  • 难治性癫痫合并语言障碍的生酮饮食治疗

    生酮饮食(Ketogenic diet, KD)疗法有近100多年的历史, 是一种高脂肪, 低碳水化合物, 合适的蛋白及营养素的配方饮食疗法, 目前被广泛运用到难治性癫痫的治疗当中, 取得了一定的疗效。越来越多的研究证据表明KD对难治性癫痫患者的认知功能的改善有一定的促进作用; 甚至有些病例癫痫发作控制不理想, 患者的语言功能和(或)运动功能也能得到一定的改善。KD治疗难治性癫痫的机制尚未完全明确, 但其疗效已被大量的研究证实; 对于癫痫所致语言障碍方面的生酮饮食治疗方面文献较少, 目前尚缺乏共识性的诊断和疗效判断标准。现就难治性癫痫合并语言障碍的定义及评价标准、癫痫和语言障碍的关系, 以及近年来KD对癫痫伴发语言障碍的治疗作用进展作一综述。

    Release date:2016-10-02 06:51 Export PDF Favorites Scan
  • Protocol optimization for treatment of infantile spasms with high dose prednisone

    ObjectiveTo optimize the therapy protocols of high dose prednisone combined with topiramate (TPM) in children with infantile spasms (IS). MethodsSixty cases were collected in our hospital from September 2012 to September 2013 and randomly divided into two groups(n=30) and followed-up for more than 6 months.The spasms were assesses by video-electroencephalogram (VEEG) monitoring including awake and asleep states before treatment, after two weeks of therapy and the end of the courses respectively.And the Gessel developmental quotient (DQ) scores were performed before treatment and after six months of therapy. ResultsFor the unresponders to high dose prednisone in one week of therapy, there were 46.67%and 60.00% in test group higher than 31.25% and 37.50% in control group respectively in 2 week and in the end of treatment.And the rate of complete resolution of hypsarrhythmia in the test group was 46.67% and 60.00% higher than 25.00% and 37.50% in control group respectively in 2 week and in the end of treatment.But there were no statistical significances between two groups(P >0.05).The incidence of side effects(83.33% vs. 80.00%) and the relapse rate(39.14% vs. 40.00%), were not statistically significant between two groups(P >0.05).The responsive rates for the cases with the lead time within 2 months higher than beyond 2 months in two groups respectively in 2 weeks and in the end of treatment. ConclusionsThe protocol of the test group was superior to that of the control group.The responsive rates of children within 2 months of lead time were higher than beyond 2 months, which indicates that early diagnosis and early treatment would improve efficacy and have an important influence on the prognosis of IS.

    Release date:2017-05-24 05:46 Export PDF Favorites Scan
  • The clinical features of congenital hyperinsulinemia presenting seizures as the initial symptoms

    ObjectiveTo analyze the clinical data of 5 cases of congenital hyperinsulinemia with sizures as the initial symptoms. MethodsRisk factors in perinatal period, clinical manifestation, laboratory examination, treatment and follow-up visits of 5 cases of congenital hyperinsulinemia with sizures as the initial symptoms were analyzed retrospectively, who were admitted to Department of Neurology of Jiangxi Children's Hospital from July 2012 to August 2016. Results5 children were all male. The onset time varied from 3 to 9 mouths old. All the cases presented seizures as the main clinical manifestations, persistent hypoglycemia, hyperinsulinemia, low free fatty acid and hypoketonemia. During follow-up, treatment with diazoxide and dietary therapy was effective in 3 cases, pure dietary therapy ineffective in 2 cases. 3 cases manifested as acute symptomic seizures, 2 cases as remote symptomic epilepsy. During follow-up, 1 cases showed normal intelligence, 3 cases developmental delay, and 1 case dropout. ConclusionMost of the infants with congenital hyperinsulinemia presented seizures as initial symptoms. Severe hypoglycemia and long duration would damage brain, and early management may significantly improve the prognosis. The early diagnosis can be made by measuring fasting blood glucose, insulin, free fatty acid and, plasma β-hydroxybutyric acid, C peptide and so on. The majority of children were effective by diazoxide.

    Release date:2017-07-26 04:06 Export PDF Favorites Scan
1 pages Previous 1 Next

Format

Content