【摘要】 目的 探讨机械法准分子激光角膜上皮瓣下磨镶术（Epi-LASIK）对大视杯高度近视患者的视网膜神经纤维层 （RNFL）的影响。 方法 对2007年1月-2009年1月拟行Epi-LASIK手术的眼底杯盘比gt;0.5的44例44只眼行光相干断层扫描（OCT）检查，测量以视盘为中心、直径为3.4 mm的RNFL厚度， 以象限图分4个区域（上方、下方、颞侧、鼻侧）显示。并分别于手术前及手术后第10 天，1、3 个月，1、2年进行随访。对所测数据进行方差分析。 结果 RNFL厚度测量结果显示， 手术前上方、下方、鼻侧、颞侧RNFL厚度与手术后比较， 差异均无统计学意义（Pgt;0.05）。 结论 Epi-LASIK手术对大视杯近视的RNFL厚度无明显影响。【Abstract】 Objective To investigate the effects of Epi-LASIK on retinal nerve fiber layer (RNFL) thickness in patients with large cup. Methods Forty-four patients (44 eyes) with high myopia from January 2007 to January 2009, whose C /D area ratios were above 0.5, underwent optical coherence tomography(OCT)examination. To measure the RNFL thickness taking optic disk as the center, diameter as 3.4 mm, for quadrant graph as above, below, temporal, lateral. After the operation in the first 10 days, and one, three months, and one, two years after surgery were followed. The data were analyzed by analysis of variance. Results The RNFL thickness at every quadrant had no statistical significant difference between preoperative period and postoperative time(Pgt;0.05). Conclusion Epi-LASIK surgery has no effect on RNFL thickness in high myopic patients with large cup.