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find Author "李东红" 3 results
  • Lennox-Gastaut综合征患者的非药物治疗——生酮饮食和迷走神经刺激

    Lennox-Gastaut综合征(Lennox-Gastaut syndrome,LGS)的患者常常对于药物治疗无效或耐药。对于这些药物难治性患者,生酮饮食(Ketogenic diets,KD)和迷走神经刺激(Vagus nerve stimulation,VNS)可作为非药物治疗的选择。传统的KD用于癫痫治疗已经有90余年的历史了,它是一种高脂、低碳水化合物饮食,其中90%的热量来自于脂肪。KD治疗对于约半数的LGS患者有效,癫痫发作可减少50%以上,有些患者癫痫发作甚至可减少90%以上。VNS疗法,需要手术植入一个刺激发生器,它可以通过缠绕在左侧迷走神经上的电极对大脑进行间断性电刺激。VNS作为辅助疗法可用于不宜手术治疗的药物难治性癫痫患者(包括LGS)。与KD相似,VNS对约半数的LGS患者有效,癫痫发作将减少50%以上,而且随时间的推移,疗效会逐渐增强。KD和VNS均可作为LGS患者的治疗选择。

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  • Salpingectomy before IVF-ET for Hydrosalpinx among Chinese Women: A Systematic Review

    Objective To assess the necessity and effectiveness of salpingectomy before IVF-ET for hydrosalpinx among Chinese infertile patients. Methods The relevant papers published from 2000 to December of 2010 in China were electronically searched in CBM, VIP and CNKI to collect randomized controlled trials (RCTs) involving Chinese hydrosalpinx women with or without salpingectomy before IVF-ET. The quality of the included trials was independently assessed by two reviewers, and the data were extracted and analyzed by RevMan 5.0 software. Results Nine RCTs involving 687 patients and 730 IVF-ET cycles were identified. The results of meta-analyses showed that: a) There were significant differences between the two groups in Gn dosage (WMD=1.23, 95%CI 0.17 to 2.30, P=0.02), fertilization rate (RR=1.07, 95%CI 1.02 to 1.13, P=0.006), cleavage rate (RR=1.05, 95%CI 1.00 to 1.09, P=0.03), clinical pregnancy rate (RR=1.92, 95%CI 1.41 to 2.61, Plt;0.000 1), and abortion rate (RR=0.34, 95%CI 0.13 to 0.86, P=0.002); and b) There were no significant differences between the two groups in days of Gn (WMD= –0.27, 95%CI –0.59 to 0.06, P=0.11), E2 in HCG day (WMD=59.15, 95%CI –9.61 to 127.91, P=0.09), number of eggs (WMD= –0.27, 95%CI –0.44 to 0.99, P=0.46), quality embryonic rate (RR=1.02, 95%CI 0.91 to 1.14, P=0.79), and ectopic pregnancy rate (RR=0.22, 95%CI 0.03 to 1.82, P=0.16). Conclusion The current evidence shows that salpingectomy before IVF-ET for hydrosalpinx Chinese hydrosalpinx patients is necessary and effective. For the low quality of methodology of the included studies, more reasonably-designed and double-blind RCTs with large sample are required to provide more high-quality proof.

    Release date:2016-09-07 11:07 Export PDF Favorites Scan
  • 应用头皮脑电高频振荡自动检测方法评估婴儿痉挛症经 ACTH 冲击治疗的疗效和预后

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