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find Author "李春生" 3 results
  • 原发性视网膜色素变性合并视网膜血管瘤一例

    Release date:2016-09-02 06:34 Export PDF Favorites Scan
  • 硫化氢在炎症反应和ALI /ARDS中的作用机制

    内源性气体信号分子硫化氢( H2S) 被发现后,其在呼吸系统等全身多个系统生理与病理生理过程都发挥了重要的作用。研究发现, H2S 在炎症发生、发展过程中以及在ALI/ARDS 等呼吸系统发挥抗炎或促炎, 抗氧化应激等多个方面作用。现将H2S 与炎症反应的关系, 尤其是在ALI/ARDS 的作用做一综述。......

    Release date:2016-09-13 04:00 Export PDF Favorites Scan
  • Role of Cyclooxygenase-2 in Liver Injury Induced by Severe Acute Pancreatitis

    Objective To investigate the expression of cyclooxygenase-2 (COX-2) in liver tissue of severe acute pancreatitis (SAP) rats. Methods A rat model of SAP was induced by retrograde infusion of 3.5% sodium taurocholate into the biliary-pancreatic duct. Eighty rats were randomly divided into SAP group and control group. The levels of serum amylase (AMY), alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor (TNF) -α and ascites AMY were detected dynamically at 4 h, 8 h, 16 h and 24 h after operation. The pancreatic and liver injuries were observed by light microscope. The expression of COX-2 in liver tissue was measured by immunohistochemistry. Results Compared with the control group, the levels of serum AMY, ALT, AST, TNF-α and ascites AMY increased significantly at the time point of 4 h, 8 h, 16 h and 24 h (Plt;0.05). These changes were paralleled with the histopathological changes of pancreatic and liver tissue. The expression positive rates of COX-2 at the different time in the SAP group were higer than those of the control group (Plt;0.05). There was a significantly positive correlation between the expression of COX-2 and ALT (rs=0.949, P=0.039), AST (rs=0.972, P=0.016) and serum AMY (rs=0.944, P=0.041), respectively. Conclusion Overexpression of COX-2 may play an important role in liver injury during SAP.

    Release date:2016-09-08 10:52 Export PDF Favorites Scan
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