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find Author "李晓东" 22 results
  • An Algorithm for Correcting Fetal Heart Rate Baseline

    Fetal heart rate (FHR) baseline estimation is of significance for the computerized analysis of fetal heart rate and the assessment of fetal state. In our work, a fetal heart rate baseline correction algorithm was presented to make the existing baseline more accurate and fit to the tracings. Firstly, the deviation of the existing FHR baseline was found and corrected. And then a new baseline was obtained finally after treatment with some smoothing methods. To assess the performance of FHR baseline correction algorithm, a new FHR baseline estimation algorithm that combined baseline estimation algorithm and the baseline correction algorithm was compared with two existing FHR baseline estimation algorithms. The results showed that the new FHR baseline estimation algorithm did well in both accuracy and efficiency. And the results also proved the effectiveness of the FHR baseline correction algorithm.

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  • 乳腺癌扁桃体转移1例报告

    患者,女,65岁。因咽痛、吞咽困难2个月入院。2个月前不明原因出现咽痛,吞咽困难,且逐渐加重,无头痛、无发热、咳嗽,经抗感染治疗无效,以慢性扁桃体炎收入院。2年前行左乳腺癌根治术,术后病理检查结果为乳腺浸润性导管癌,腋下淋巴结癌转移4/15。未行放、化疗。查体: 一般状况差、消瘦,左扁桃体Ⅲ°大,色暗红,表面糜烂,有坏死组织。左颌下淋巴结肿大,左乳房已切除见长25 cm手术瘢痕。余未见异常。入院后,行血、尿常规、心电图、胸部X线及腹部B超检查,均未见异常。在局麻下行扁桃体及左颌下肿大淋巴结切除术,术中见扁桃体肥大,质脆、糜烂。术后病理诊断为乳腺癌扁桃体及颌下淋巴结转移。

    Release date:2016-08-28 04:48 Export PDF Favorites Scan
  • SURGICAL EXPERIENCE OF EXTRAHEPATIC PORTAL HYPERTENSION FROM 42 CASES

    目的探讨肝外型门静脉高压症的外科治疗经验。方法1993年1月至1999年12月,我科收治肝外型门静脉高压症42例,男19例,女23例,年龄8~58岁,平均24.6岁,经B超、动脉造影、脾静脉造影和术中探查,诊断为门静脉血栓形成34例,内脏动静脉瘘5例,终末支门静脉纤维化2例,肝动脉瘤压迫门静脉1例。根据病变不同,分别给予肠腔分流、脾肾分流、经导管溶栓及栓塞或动静脉瘘切除等治疗。结果术后2例死亡,并发肝脓肿1例,肠坏死1例,其余患者均获满意疗效。有31例随访5个月~6年无复发。结论肝外型门静脉高压症只要选择好合理的治疗方法,可获满意疗效,且远期效果良好。

    Release date:2016-08-28 05:10 Export PDF Favorites Scan
  • 关节镜下自体髌腱重建前交叉韧带五例

    Release date:2016-09-01 09:33 Export PDF Favorites Scan
  • The Application of 3D Plug in Tensionfree Hernia Ring Padding Herinorrhaphy

    目的:探讨3D网塞在腹股沟疝修补术中的应用。方法:随机选取30例腹股沟疝患者用3D网塞行无张力疝修补术。结果:本组平均手术时间35 min,平均术中出血15 mL。术后8~24 h下地活动,均未给镇痛药,无手术死亡、无切口感染、阴囊血肿等并发症,患者局部舒适性好,异物感不明显,随访5~10个月,无一例复发。结论:使用3D网塞作为充填式疝修补材料具有手术创伤小、恢复快,患者局部舒适性好,复发率低等优点。

    Release date:2016-09-08 09:54 Export PDF Favorites Scan
  • Efficacy of LDL-C lowering therapy in patients with non-ST-segment elevation acute coronary syndrome: a meta-analysis

    Objective To investigate the efficacy of LDL-C lowering treatment on NSTE-ACS, and to analyze the target LDL-C level for clinical treatment. Methods PubMed, EMbase, the Cochrane Central Register of Controlled Trials, Web of Science databases were searched up to January 2016 for randomized controlled trials assessing the effects of LDL-C lowering therapy on major adverse cardiac events (MACE) in patients with NSTE-ACS. Two reviewers independently screened litertures, extracted data and assessed the risk of bias of included studies, and then meta-analysis was performed by using Stata12.0 and RevMan 5.3 software. Result A total of 12 RCT including 4 702 individuals with NATE-ACS were included. The results of meta-analysis showed that, compared with the control group, the statin group could significantly reduced the risk of MACE (RR=0.68, 95% CI 0.549 to 0.834,P=0.000). With 18.68 months of follow-up, patients in target LDL-C level from over 70 mg/dL to less than 100 mg/dL group had lower risk of MACE than other LDL-C level group. When LDL-C lower 20% to 40% than baseline with 28.99 months follow-up, patients in target of LDL-C level from over 70 mg/dL to less than 100 mg/dL group had lowest risk of MACE (RR=20.143, 95% CI 6.946 to 58.414,P=0.000). Conclusion LDL-C lower treatment can lower the risk of MACE in patients with NSTE-ACS. Patients in target LDL-C level from over 70 mg/dL to less than 100 mg/dL group have relatively low risk of MACE, in which patients who lower 20% to 40% LDL-C than baseline will get more benefits from LDL-C lowering therapy.

    Release date:2017-05-18 02:12 Export PDF Favorites Scan
  • 4种解剖标志帮助识别胆囊管避免胆管损伤(附316例报道)

    目的 总结 4 种解剖标志在腹腔镜胆囊切除术中对胆囊管的辨识作用。 方法 收集 2016 年 3 月至 2017 年 9 月期间四川省德阳市人民医院行腹腔镜胆囊切除术(传统的 3 孔法或 4 孔法)的患者共 316 例,术中用4 种解剖标志中的至少 2 种进行相互印证辨识清楚胆囊管后再切断胆囊管。 结果 316 例患者中,有 3 例患者因术中意外原因中转开腹;有 1 例患者因长期慢性炎症造成胆囊管挛缩、增厚水肿的胆囊颈紧贴胆总管,应用 4 种解剖标志成功辨识出此种变异,术中顺利切除胆囊;其他患者顺利辨识出胆囊管并成功切除胆囊,无一例患者发生胆管损伤。 结论 笔者总结的这 4 种解剖标志的寻找与相互印证可以很好地帮助识别胆囊管,从而避免在腹腔镜胆囊切除术中的胆管损伤。

    Release date:2018-09-11 11:11 Export PDF Favorites Scan
  • 脾海绵状血管瘤囊性变并脾功能亢进1例报告

    Release date:2016-08-29 09:20 Export PDF Favorites Scan
  • Research on algorithms of uterine contraction curve analysis and its real-time status identification

    Identification of real-time uterine contraction status is very significant to labor analgesia, but the traditional uterine contraction analysis algorithms and systems cannot meet the requirement. According to the situations mentioned above, this paper designs a set of algorithms for the real-time analysis of uterine contraction status. The algorithms include uterine contraction signal preprocessing, uterine contraction baseline extraction based on histogram and linear iteration and an algorithm for the real-time analysis of uterine contraction status based on finite state machines theory. It uses the last uterine status and a series of state transfer conditions to identify the current uterine contraction status, as well as a buffer mechanism to avoid false status transitions. To evaluate the performance of the algorithm, we compare it with an existing uterine contraction analysis algorithm used in the electronic fetal monitor. The experiments show that our algorithm can analyze the uterine contraction status while monitoring the uterine contraction signal in a real-time. Its sensitivity reaches 0.939 9 and its positive predictive value is 0.869 3, suggesting that the algorithm has high accuracy and meets the need of clinical monitoring.

    Release date:2017-10-23 02:15 Export PDF Favorites Scan
  • EFFECT OF GLUCOCORTICOID ON EXPRESSION LEVELS OF OSTEOPROTEGERIN/RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B LIGAND-MATRIX METALLOPROTEINASE TISSUE INHIBITOR OF MATRIX METALLOPROTEINASE SYSTEM IN BONE TISSUES OF FEMORAL HEAD OF RATS

      Objective To investigate the effect of glucocorticoid on the expression levels of osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL)-matrix metalloproteinases (MMP)/tissue inhibitor of matrix metalloproteinase (TIMP) system in bone tissues of femoral head of rats, and to discuss its interrelated action mechanism in glucocorticoid-induced avascular necrosis of femoral head (ANFH). Methods Forty adult Sprague Dawley rats, weighing 250-300 g, half males and half females, were randomly divided into 4 groups: high dose glucocorticoid group (HD, n=10), medium dose glucocorticoid group (MD, n=10), low dose glucocorticoid group (LD, n=10), and control group (n=10). The rats in HD group, MD group, and LD group were intramuscularly injected with 25.0, 12.5, and 7.0 mg/kg of prednisolone respectively, and the rats in the control group were injected with physiological saline. After 4 weeks intervention, the osteonecrosis of left femoral heads was observed by HE staining, total RNA was extracted from the right femoral head bone tissue and the mRNA expression levels of OPG, RANKL, MMP-2, MMP-9, TIMP-1, and TIMP-2 were detected by RT-PCR. Results After injection of prednisolone, 4 rats of HD group and 1 rat of MD group died of systemic failure caused by the decreased food and weight culminating in cachexia. HE staining showed that the integrity of bone trabecula and osteon was destroyed at different levels, discontinuous bone chips formed, and osteocytes were replaced by granulation tissue in some lacunae in HD, MD, and LD groups; the integrated osteon was observed, the lamellar structure formed concentric circles around the blood vessel and osteocytes were seen in the lacunae in the control group. The necrosis rates of femoral head were 83.3% (5/6), 66.7% (6/9), 30.0% (3/10), and 0 (0/10) in HD, MD, LD, and control groups. The results of RT-PCR showed: the mRNA expression levels of the OPG, TIMP-1, TIMP-2 in HD, MD, and LD groups were lower than those in the control group, showing significant differences (P lt; 0.05) and there was negative correlation with the hormone dosage. The difference in OPG expression was significant between the hormone groups (P lt; 0.05); the differences in the TIMP-1 and TIMP-2 expressions were not significant between the LD group and MD group (P gt; 0.05), but there were significant differences when compared with HD group (P lt; 0.05). The RANKL, MMP-2, and MMP-9 mRNA expression levels in HD, MD, and LD groups were higher than those in the control group and there was a positive correlation with the hormone dosage, showing significant differences when compared MD and HD groups with control group (P lt; 0.05); there was no significant difference in RANKL expression between HD group and MD group (P gt; 0.05), but there was significant difference when compared HD and MD groups with LD group (P gt; 0.05); no significant difference was observed in the MMP-2 and MMP-9 expression between MD group and LD group (P gt; 0.05), but the differences were significant when compared with HD group (P lt; 0.05). Conclusion Glucocorticoid-induced ANFH may be related to the expression levels of OPG/RANKL-MMP/TIMP mRNA regulated by glucocorticoid.

    Release date:2016-08-31 05:43 Export PDF Favorites Scan
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