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find Author "李智" 17 results
  • 胸腔积液及高脂血症对重症急性胰腺炎发生的预测作用

    目的探讨胸腔积液、高脂血症与重症急性胰腺炎(SAP)早期诊断的关系。 方法2010年1月-2014年3月对入院24 h内的120例急性胰腺炎患者按2013年《中国急性胰腺炎诊治指南》的诊断标准分为SAP组(68例)和轻症急性胰腺炎(MAP)组(52例)。两组均行胸腹部CT及血脂分析检查,记录胸腔积液、高脂血症以及胸腔积液并高脂血症与SAP发病例数、病死率、腹水、肝功能不全、胰腺假性囊肿的关系。 结果SAP组与MAP组胸腔积液分别为57例(83.8%)和12例(23.1%),高脂血症分别为52例(76.5%)和17例(32.7%),胸腔积液并高脂血症分别为47例(69.1%)和7例(13.5%),差异有统计学意义(P<0.001)。SAP组患者中,是否并发胸腔积液者病死率、胰腺假性囊肿发生率差异无统计学意义(P>0.05),并发胸腔积液者腹水、肝功能不全发生率发生率高于无胸腔积液者(P<0.05);是否合并高脂血症者病死率、胰腺假性囊肿发生率差异无统计学意义(P>0.05),合并高脂血症者腹水和肝功能不全发生率均高于未合并高脂血症者(P<0.05);是否同时合并胸腔积液和高脂血症者胰腺假性囊肿发生率差异无统计学意义(P>0.05),同时合并胸腔积液和高脂血症者病死率、腹水发生率、肝功能不全发生率均高于未同时合并胸腔积液和高脂血症者(P<0.05)。 结论胸腔积液、高脂血症与SAP发生有密切关系,同时还与部分并发症有关,检测这两项指标,对SAP早期诊断及并发症的早期干预有意义。

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  • Effects of human urine-derived stem cells combined with chondroitinase ABC on the expressions of nerve growth factor and brain-derived neurotrophic factor in the spinal cord injury

    Objective To explore the effects of human urine-derived stem cells (hUSCs) and hUSCs combined with chondroitinase ABC (chABC) on the expressions of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the spinal cord injury (SCI) of rats, and to investigate the underlying mechanism. Methods hUSCs were cultured from human urine, and their phenotypes were detected by flow cytometry. The SCI model of rats were made via Allen method. Sixty Sprague Dawley rats were divided into 5 groups (n=12): the sham operation group (group A), SCI group (group B), SCI+hUSCs group (group C), SCI+chABC group (group D), and SCI+hUSCs+chABC group (group E). Basso, Beattie, Bresnahan (BBB) score was used to measure the lower extremity motor function of rats in each group at 10, 20, and 30 days after operation. Real-time fluorescent quantitative PCR was used to detect the relative mRNA expressions of NGF and BDNF at 30 days. Meanwhile, the protein expression of NGF and BDNF were confirmed by immunohistochemistry staining. The relative protein expressions of Bax and Bcl-2 were detected by Western blot. Results The hUSCs were identified to have multipotential differentiation potential. At 10, 20, and 30 days, BBB score was significantly lower in group B than in groups A, C, D, and E, in groups C, D, and E than in group A, in groups C and D than in group E (P<0.05). Real-time fluorescent quantitative PCR and immunohistochemistry staining demonstrated that the expressions of NGF and BDNF were significantly lower in group B than in groups A, C, D, and E, in groups C, D, and E than in group A, in groups C and D than in group E (P<0.05); but there was no significant difference between groups C and D (P>0.05). Western blot results indicated that the protein expression of Bax was significantly higher in group B than in groups A, C, D, and E, in groups C, D, and E than in group A, in groups C and D than in group E (P<0.05). Meanwhile, the protein expression of Bcl-2 was significantly lower in group B than in groups A, C, D, and E, in groups C, D, and E than in group A, in groups C and D than in group E (P<0.05). Conclusion hUSCs can protect SCI and this positive effect can be enhanced by chABC; this neuro-protective effect may depend on promoting the expressions of NGF and BDNF, and suppressing the neuronal apoptosis.

    Release date:2017-11-09 10:16 Export PDF Favorites Scan
  • 以团队为基础的学习教学模式在外科护理教学中的应用前景探讨

    目的 探讨以团队为基础的学习(TBL)教学模式在本科外科护理教学中的应用前景。 方法 通过分析TBL教学模式特点及收集近年来国内外本科外科护理教学中TBL的应用文献,对我院本科外科护理教学开展TBL的必要性、可行性及前景进行分析和展望。 结果 本科外科护理教学中TBL有助于学生自主学习的积极性和参与性,提高分析问题和解决问题能力。 结论 TBL作为一种全新的教学方法,其模式的广泛应用与不断完善,将为外科护理高素质专业人才的培养发挥积极性的作用。

    Release date:2021-06-23 07:35 Export PDF Favorites Scan
  • 序贯疗法根除初治失败幽门螺杆菌疗效观察

    【摘要】 目的 分析总结雷贝拉唑、阿莫西林、克拉霉素、替硝唑组成的10日序贯疗法根除初治失败幽门螺杆菌(Helicobacter pylori,Hp)的疗效。 方法 将2009年5月-2011年5月在消化科门诊及住院经胃镜确诊的胃、十二指肠溃疡患者65例,经标准三联疗法治疗4周后Hp仍阳性的患者随机分为两组,治疗组33例前5 d用雷贝拉唑10 mg、阿莫西林1.0,每日2次口服,后5 d用雷贝拉唑10 mg、克拉霉素500 mg、替硝唑500 mg,每日2次口服;对照组32例用雷贝拉唑10 mg、枸橼酸铋钾600 mg、呋喃唑酮0.1 g、阿莫西林1.0 g,每日2次,疗程10 d。停药4周后复查Hp。 结果 治疗组Hp根除率81.8%,对照组75.0%,两组比较无统计学意义(Pgt;0.05)。不良反应率分别为12.1%和34.3%,两组比较有统计学意义(Plt;0.05)。 结论 序贯疗法对初治失败Hp根除率高于四联疗法但无统计学意义,不良反应率低于对照组,可作为根除初治失败Hp的一种有效方案。

    Release date:2016-09-08 09:27 Export PDF Favorites Scan
  • 可大龙不同给药浓度对输注血管的影响

    目的:本研究旨在了解可达龙不同给药浓度对输注血管的影响。方法:将2006~2008年对房颤行三维射频消融术后使用可达龙48例患者随机分为两组,即实验组和对照组,实验组的可达龙药物浓度为1.2 mg/ mL,以0.5 mg/min匀速输注;对照组为12 mg/ mL,以0.5 mg/min匀速输注,观察不同给药浓度对输注血管的影响。结果:对照组组静脉炎的发生率显著高于实验组. 结论:可大龙不同给药浓度对输注血管的影响显著。

    Release date:2016-09-08 09:56 Export PDF Favorites Scan
  • 不予体位限制和沙袋压迫对全麻下行介入术后先心患儿的影响

    目的:旨在探讨不予体位限制和穿刺处沙袋压迫对全麻下行介入术后的先心患儿的影响。方法:将2007 年1 月至 2008 年12 月的50 例全麻下行介入术清醒后送入CCU(冠心病监护病房)先心患儿随机分成2组(即实验组和对照组),两组均用弹力绷带加压包扎穿刺处的前提下,对照组按常规给患儿取平卧位,头偏向一侧,穿刺侧肢体制动,并沙袋压迫穿刺处8~12h,平卧12h或以上;实验组患儿穿刺侧肢体不予制动,穿刺处也不沙袋压迫,患儿可取任意体位(包括由父母抱在怀中休息),观察两组患儿舒适度、穿刺处出血并发症、患儿父母、医护人员等的影响。结果:实验组患儿的舒适度、对患儿父母、医护人员的影响明显优于对照组,而穿刺处出血并发症方面两组无显著差异。 结论:不予体位限制和穿刺处沙袋压迫对全麻下行介入术后先心患儿的影响是增加患儿的舒适度,减少患儿父母的焦虑,减轻医护人员的工作负荷,而穿刺处出血并发症不增加。

    Release date:2016-09-08 10:00 Export PDF Favorites Scan
  • 权变理论在大型灾害时手术资源调度中的应用研究

    目的总结大型灾害发生后如何有效调度手术资源的方法。 方法对2013年4月20日-22日芦山地震发生后,就应急手术中的护理人员、医疗物质的调度方式及效果进行回顾分析。 结果在灾害发生后的72 h内顺利完成各类手术69台,骨科手术共计30台,其中脊柱骨折15台、肢体骨折12台、骨科复合术3台;神经外科血肿清除术17台;儿外科手术12台;普外科剖腹探查术8台;胸外行剖胸探查术2台。平均开放时间180 min。术后3 d随访,伤员生命体征平稳,均未发生院内感染,于不同时间段痊愈出院。 结论权变理论的应用,可以灵活机动的调动各种资源,保证组织目标的实现,确保地震手术患者的救治需求。

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  • 应用医护一体化提高眼科手术部位标识率

    目的了解实施医护一体化模式对提高眼科手术部位标识率的效果。 方法2013年6月-9月共调查了2 176例眼科手术患者的手术部位标识情况,其中2013年6月-7月为实施医护一体化前,共1 012例;2013年8月-9月为实施医护一体化后,共1 164例。对实施医护一体化前后眼科手术部位标识率的情况进行调查分析。 结果实施医护一体化后,眼科手术部位的标识率、规范性都有了明显的提高,标识率由改进前的52.86%提高到94.97%,标识的颜色、位置、形态有了明显的规范。 结论手术部位标识的应用大大促进了医生和护士对手术患者安全管理的关注,实施医护一体化后眼科手术部位的标识率、规范性明显提高,值得推广和应用。

    Release date:2016-10-02 04:54 Export PDF Favorites Scan
  • Arrhythmia heartbeats classification based on neighborhood preserving embedding algorithm

    Arrhythmia is a kind of common cardiac electrical activity abnormalities. Heartbeats classification based on electrocardiogram (ECG) is of great significance for clinical diagnosis of arrhythmia. This paper proposes a feature extraction method based on manifold learning, neighborhood preserving embedding (NPE) algorithm, to achieve the automatic classification of arrhythmia heartbeats. With classification system, we obtained low dimensional manifold structure features of high dimensional ECG signals by NPE algorithm, then we inputted the feature vectors into support vector machine (SVM) classifier for heartbeats diagnosis. Based on MIT-BIH arrhythmia database, we clustered 14 classes of arrhythmia heartbeats in the experiment, which yielded a high overall classification accuracy of 98.51%. Experimental result showed that the proposed method was an effective classification method for arrhythmia heartbeats.

    Release date:2017-04-01 08:56 Export PDF Favorites Scan
  • 快速康复外科在大肠癌患者应用中的焦虑心理及护理研究进展

    探讨快速康复外科(FTS)模式在大肠癌患者运用中的焦虑心理现状。通过查阅国内外相关文献,了解分析FTS模式导致大肠癌患者产生焦虑心理的原因,并就FTS模式下患者焦虑心理的护理干预措施进行逐一阐述与总结,以期在患者焦虑情绪控制和缓解的基础上,促进FTS模式在大肠癌患者治疗中的有效应用。

    Release date:2016-09-07 02:38 Export PDF Favorites Scan
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