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find Author "李朝晖" 4 results
  • Exchange of Cerebrospinal Fluid for Subarachnoid Hemorrhage:A Randomized Controlled Trial

    Objective To explore the effectiveness and safety of exchange of cerebrospinal fluid in the treatment of subarachnoid hemorrhage (SAH). Methods Sixty SAH patients diagnosed by CT and lumbarpuncture were randomly assigned into a control group (n =30, received conventional treatment) and a treatment group (n =30, received exchange of cerebrospinal fluid plus conventional treatment). The main complications and effectiveness between the two groups were compared. SPSS 10.0 was used for statistical analysis. Results Compared with the control group, complications of persistent headache ( P =0.002 and 0. 007 respectively), cerebral vasospasm ( P =0. 028 ) and hydrocephalus ( P =0. 038 ) were fewer in the treatment group. No significant difference in the incidence of rehaemorrhagia was found between the two groups (P = 1. 000). Better effectiveness was observed in the treatment group (RR. 3.00, 95% CI 1. 014 to 8. 880, P = 0. 044 ). Conclusions Exchange of cerebrospinal fluid plus conventional treatment is more effective than conventional treatment alone in the treatment of SAH.

    Release date:2016-08-25 03:34 Export PDF Favorites Scan
  • 农娱治疗对慢性精神分裂症患者认知功能恢复作用

    目的 探索农娱治疗对慢性精神分裂症患者认知功能恢复的作用。 方法 对1994年4月-2008年12月收治的80例住院慢性精神分裂症患者随机分为干预组和对照组,对照组给予常规治疗,干预组除常规治疗外,实施自行设计的农娱治疗,治疗时间为6个月,使用韦氏记忆测验(WMS)及威斯康星卡片分类测试(WCST)测评。 结果 两组患者在治疗前WMS、WCST各因子分及总评总和分(指各因子总评分相加)比较,无统计学意义(Pgt;0.05);治疗后对照组与干预组间记忆商数、正确应答数和持续错误数比较均有统计学意义(Plt;0.05)。 结论 农娱治疗可改善慢性精神分裂症患者的认知功能,促进其积极参加人际交往、参与社会生活,在精神分裂症全程治疗中起到了积极作用。

    Release date:2016-09-08 09:47 Export PDF Favorites Scan
  • 伴鼻侧睫状视网膜动脉供血的视网膜中央动脉阻塞一例

    Release date:2018-05-18 06:38 Export PDF Favorites Scan
  • Clinical study of calcium phosphate cement loaded with recombinant human bone morphogenetic protein 2 combined with calcium phosphate cement loaded with antibiotic for chronic osteomyelitis with bone defect

    ObjectiveTo compare the effectiveness of calcium phosphate cement (CPC) loaded with recombinant human bone morphogenetic protein 2 (rhBMP-2) combined with CPC loaded with antibiotic versus CPC loaded with antibiotic alone in one stage for chronic osteomyelitis with bone defect.MethodsA single-blind prospective randomized controlled clinical trial was conducted. Between April 2018 and April 2019, 80 patients of chronic osteomyelitis with bone defect in accordance with the random number table were randomly divided into two groups, 40 in the trial group (CPC loaded with rhBMP-2 combined with CPC loaded with antibiotic) and 40 in the control group (CPC loaded with antibiotic). There was no significant difference in gender, age, disease duration, lesion, and preoperative white blood cells (WBC) count, platelet count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) between the two groups (P>0.05). All patients were implanted the corresponding CPC and external fixator after lesion clearance in the two groups. The postoperative WBC count, platelet count, ESR, CRP, hospital stay, cure rate of osteomyelitis, repaired bone defect volume, the time of external fixator removal, and the time of full weight-bearing of the affected limb were compared between the two groups.ResultsAll patients were followed up 12-24 months, with an average of 18.4 months. There was no significant difference in WBC count, platelet count, ESR, and CRP between the two groups at 4 weeks after operation (P>0.05). There were significant differences in WBC count, platelet count, and CRP in the two groups between 1 week before operation and 4 weeks after operation (P<0.05). And the ESR showed no significant difference between pre- and post-operation in the two groups (P>0.05). In the trial group, the anaphylactic exudate occurred in 1 patient with tibial osteomyelitis and the incision healed after oral administration of loratadine. The incisions of other patients healed by first intention in the two groups. One case of distal tibial osteomyelitis recurred in each group, and 1 case of humeral osteomyelitis recurred in the control group. The cure rates of osteomyelitis were 97.5% (39/40) in the trial group and 95% (38/40) in the control group, showing no significant difference between the two groups (χ2=0.000, P=1.000). There was no significant difference in the repaired bone defect volume and hospital stay between the two groups (P>0.05). X-ray film and CT showed that the bone defects were repaired in the two groups. The time of external fixator removal and the time of full weight-bearing of the affected limb were significantly shorter in the trial group than in the control group (P<0.05).ConclusionApplication of CPC loaded with rhBMP-2 and antibiotic in one stage is effective for the chronic osteomyelitis with bone defect, which can accelerate the bone regeneration in situ to repair bone defect, reduce the trauma, shorten the course of treatment, and obtain good function of the affected limb.

    Release date:2021-06-07 02:00 Export PDF Favorites Scan
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