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find Author "李永霞" 6 results
  • 三阴乳腺癌的内科治疗进展

    三阴乳腺癌是乳腺癌中一类影响乳腺癌预后的特殊类型,因其临床及病理特点的特殊性,导致三阴乳腺癌的治疗成为世界性的难题。近年来,研究者们对三阴乳腺癌的内科治疗进行了一系列的探索,加上三阴乳腺癌特殊靶点的发现以及靶向药物的发展,希望三阴乳腺癌通过内科治疗从而改善预后。现对其内科治疗进展进行综述。

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  • Levels of 8-Isoprostane in Serum of Patients with Bronchial Asthma

    Objective To investigate levels of 8-isoprostane in serum of patients with bronchial asthma. Methods Eighteen patients diagnosed with acute exacerbation of asthma were enrolled as the experimental group from Department of Respiratory Medicine from February 2009 to August 2009. After treatment all the patients reached remission. Twenty healthy workers from Department of Respiratory Medicine were enrolled as the control group in August 2009. The levels of 8-isoprostane in serum of all subjects were measured, and their FEV1% pred was also evaluated. Results The levels of 8-isoprostane in serum were significantly higher in patients with acute exacerbation of asthma compared with those in remission stage and the healthy control group [ ( 157. 46 ±46. 99) pg/mL vs. ( 43. 52 ±13. 62) pg/mL and( 15. 23 ±1. 96) pg/mL, P lt;0. 01] . Meanwhile the levels of 8-isoprostane in serum of patients with asthma in remission stage were significantly higher compared with the healthy control group ( P lt;0. 05) . The levels of 8-isoprostane in serum were negatively correlated with FEV1% pred in the asthma group( r = - 0. 533,P lt;0. 05) . Conclusions 8-isoprostane as amarker of oxidative stress response involves in the pathogenesis of asthma. Monitoring 8-isoprostane levels in serum may reflect the state of oxidative stress, and may be useful for severity judgment and follow-up of treatment effectiveness in patients with asthma.

    Release date:2016-08-30 11:54 Export PDF Favorites Scan
  • 肺栓塞在COPD 急性加重期中的作用

    COPD 在世界范围均是主要的健康负担, 到2020 年,COPD 将可能成为第三大的死亡原因。而大部分COPD 死亡发生在它的急性发作期。以前的研究表明50% ~70% 的COPD 急性加重( AECOPD) 是由于感染造成, 10% 归于环境因素, 超过30% 的患者发作原因并不清楚[ 1] 。其主要发作的症状是咳嗽和呼吸困难, 而肺栓塞( PE) 的症状很难从中区分。有报道认为COPD 发生PE 和其他静脉血栓形成的概率是非COPD 患者的2 倍, 同时也认为COPD 是发生PE 的主要危险因素, PE 可能是COPD 急性发作常见原因[ 2] 。而目前的COPD 诊治指南并未明确PE 是COPD 急性发作的可能原因之一, 只是在治疗中提出对卧床、红细胞增多症或脱水的患者, 无论是否有血栓栓塞性疾病史均需考虑使用肝素或低分子肝素。这种观点可能是从PE 的危险评估角度来看, 但也可能造成临床使用时抗凝剂量的不充分, 导致COPD 患者死亡。那么PE 在AECOPD 中的地位究竟如何?现就相关研究文献综述如下。

    Release date:2016-08-30 11:54 Export PDF Favorites Scan
  • 8-Isoprostane in Exhaled Breath Condensate of Patients with Asthma

    Objective To invesitgate the relationship between 8-isoprostane ( 8-iso-PG) level in exhaled breath condensates ( EBCs) and severity of asthma and explore the role of 8-iso-PG in asthma evaluation and monitoring. Methods Fifty-nine patients with asthma were enrolled. In which 15 cases were acute exacerbation, 13 cases were mild intermittent, 15 cases were mild persistent, and 16 cases were moderate-to-severe persistent. Thirteen healthy volunteers were recruited as control. EBCs were collected using EcoScreen system. The 8-iso-PG levels in EBCs were measured by a specific enzyme immunoassay.The patients with mild intermittent asthma were treated with inhaled corticosteroid ( ICS) for one month and their EBCs were recollected for 8-iso-PG measurement. Results Exhaled 8-iso-PG levels were obviously increased in the patients with acute asthma compared with those chronic asthmatics [ ( 47. 2 ±6. 8) pg/mL vs ( 24. 5 ±12. 0) pg/mL, P lt; 0. 01] . In the chronic persistent asthma, the levels were significantly higher in patients with mild persistent and moderate-to-severe asthma [ ( 17. 9 ±1. 2) pg/mL and ( 39. 7 ±4. 0) pg/mL,P lt; 0. 01] . While 8-iso-PG level did not differ significantly in intermittent asthma [ ( 13. 5 ±1. 1) pg/mL]compared with the control subjects ( P gt; 0. 05 ) . After one-month ICS treatment the 8-iso-PG level in the patients with mild intermittent asthma did not change significantly although the ACT score improved. Conclusions 8-iso-PG levels in EBC are associated with the severity of asthma, implicating 8-iso-PG may be useful in monitoring airway oxidative stress in asthma. ICS treatment is incapable of decreasing the 8-iso-PG, suggesting the ICS has minor impact on oxidative stress.

    Release date:2016-09-14 11:23 Export PDF Favorites Scan
  • 阻塞性睡眠呼吸暂停合并2型糖尿病的机制

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  • 不同杂交方式治疗累及弓部的主动脉夹层

    目的 探讨不宜单独行腔内隔绝治疗、累及弓部的主动脉夹层杂交手术治疗方法及其疗效。 方法 回顾性分析2008年11月至2011年8月成都军区总医院15例累及弓部的主动脉夹层患者行杂交手术治疗的临床资料,其中男10例,女5例;年龄51~72 (58.2±7.2)岁。Stanford A型主动脉夹层4例,B型主动脉夹层11例,病变均累及主动脉弓。采用胸骨正中切口或加颈部切口行升主动脉至头臂动脉旁路移植、单纯颈部切口行头臂动脉间旁路移植,然后行股动脉切口逆行主动脉腔内覆膜支架植入。术后即刻行数字减影血管造影(DSA),术后3个月、术后1年和2年分别随访CT造影资料,观察支架和人工血管通畅情况。 结果 所有患者均成功完成手术,并植入覆膜支架。术中血管造影证实支架植入定位准确,支架无明显内漏和移位。主动脉夹层真腔血流恢复正常,旁路血管血流通畅,围术期无死亡和严重并发症发生。随访15例,随访时间3~20 (12.0±4.1)个月,所有患者均生存,恢复正常生活。术后3个月及术后1年、2年复查主动脉增强CT示:支架无移位和内漏,支架内及人工血管旁路血流通畅,未见脑部和肢体缺血征象。 结论 累及弓部的主动脉夹层可根据受累部位和程度采用不同的杂交手术方法,安全、有效,能明显减轻患者的创伤和痛苦,该方法扩大了介入覆膜支架腔内治疗的适应证,但远期疗效有待进一步观察。

    Release date:2016-08-30 05:50 Export PDF Favorites Scan
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