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find Author "李红艳" 6 results
  • 雷贝拉唑与法莫替丁治疗十二指肠溃疡疗效比较

    消化性溃疡的治疗,已从中和胃酸、H2受体拮抗剂发展到质子泵抑制剂(PPI)第二代。经多年临床实践证实,雷贝拉唑作为新一代质子泵抑制剂,由于有独特的药理作用和很好的疗效,已广泛应用于临床。2006年3月-2009年10月我院对需贝拉唑与法莫替丁治疗十二指肠溃疡疗效进行了比较,报告如下。

    Release date:2016-09-08 09:47 Export PDF Favorites Scan
  • A Survey of Perception about Cold in Pharmacy College Students

    ObjectiveTo investigate the recognition of cold in pharmacy college students. MethodsInvestigation on the recognition of cold, treatment and anti-cold drugs were carried out by questionnaires among 158 pharmacy college students from March to July, 2013. ResultsThe annual cold frequency was mainly between once and twice in these students. The cold therapy cost in a year was between 10 and 50 Yuan, and the treatment cycle of cold was mainly between 3 and 7 days. The students were familiar with the inducement and symptoms of cold, but they didn't get adequate message of non-chemoprophylaxis methods on cold. The students knew anti-cold drugs mainly by pharmacist in drugstores, doctors and advertisements. Traditional Chinese Medicine decoction and Chinese and Western medicine mixture were their favorite drug types, and capsule, tablet and oral solution were their favorite dosage forms. ConclusionIt is necessary to strengthen college students' ability to recognize and treat cold correctly by comprehensive measures.

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  • Analysis of the status of real world studies based on the Chinese clinical trial registry

    ObjectiveTo analyze the status of real world studies (RWS) through registration information of the Chinese Clinical Trials Registry (ChiCTR). MethodsThe website of ChiCTR was searched with the real world as the search term to collect relevant registered items in the real world from inception to May 4, 2022. Descriptive analysis method was used. ResultsA total of 642 registered items were included. The median sample size was 482 cases. RWS were mainly observational studies, and the number of intervention studies was increasing year by year. There were 267 studies (41.59%) at the stage of post-marketing drugs or phase Ⅳ clinical trials. Most of the main measures were endpoints (56.23%), and the most commonly used was overall survival (15.79%). 62.15% of the registered projects met the minimum requirements for registration. ConclusionThe number of RWS registered by ChiCTR shows an increasing trend. At present, the research purpose of RWSs is unclear, and the completeness of registered studies and the overall content compliance of the studies need to be improved.

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  • Effect and mechanism of chronic oxidative stress induced by hydrogen peroxide on microglial celluar senescence

    Objective To explore the role of hydrogen peroxide (H2O2) in inducing chronic oxidative stress in microglia aging. Methods BV2 microglia purchased from ATCC in less than 10 generations were treated with 0, 50, 100, 200 μmol/L H2O2 at different concentrations. According to the concentration of H2O2 used, the BV2 microglia were divided into a control group and H2O2 -50 μmol/L Group, H2O2 -100 μmol/L Group, H2O2 -200 μmol/L Group. Cell proliferation was measured by CCK8 cell proliferation assay. Age-related β-galactosidase (SA-β-gal) staining assay, and expression of age-related cyclin molecules p16, p21, p53 and senescence sssociated secretory phenotype interleukin 1 beta (IL-1β), transforming growth factor-β (TGF-β) and matrix metalloprotein 9 (MMP9) detected by quantitative real-time polymerase chain reaction were used to measure celluar senescence. Results During the induction process, H2O2-200 μmol/L caused significant damage to BV2 microglia, therefore no subsequent testing was conducted. Finally, the control group, H2O2-50 μmol/L group and H2O2-100 μmol/L group cells were collected. The differences in cell survival rate (F=46.176, P<0.001) and positive rate of SA-β-gal staining (F=553.1, P<0.001) among the three groups were statistically significant. The cell survival rate of H2O2-50 μmol/L group had no significant change (P>0.05), while the cell survival rate of H2O2-100 μmol/L group decreased significantly (P<0.001). The positive rate of SA-β-gal staining in H2O2-50 μmol/L group and H2O2-100 μmol/L group was increased (P<0.001), and the positive rate of SA-β-gal staining in H2O2-100 μmol/L group was higher than that in H2O2-50 μmol/L group (P<0.001). The mRNA levels of senescence related cyclin molecules p16, p21 and p53 were up-regulated under the induction of 50, 100 μmol/L H2O2 (P<0.05), and the expressions of IL-1β, TGF-β and MMP9 of senescence associated secretory phenotype were increased (P<0.05). The increase of H2O2-50 μmol/L group was more obvious (P<0.05). Conclusion The aging model of BV2 microglia can be successfully established by inducing 8 d with 100 μmol/L H2O2, and the mechanism may be related to promoting the secretion of p16, p21, p53, IL-1β, TGF-β and MMP9.

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  • 俯卧位通气治疗人感染 H7N9 禽流感致重度急性呼吸窘迫综合征二例报道

    目的初步探索俯卧位通气(PPV)在人感染 H7N9 禽流感致重度急性呼吸窘迫综合征(ARDS)的疗效和安全性。方法收集福州肺科医院 RICU 2017 年 2 月至 4 月确诊人感染 H7N9 禽流感 2 例患者的 PPV 前 2 h(Pre-PPV),PPV 后 2 h、4 h、6 h、8 h、10 h、12 h(PPV-2 h、PPV-4 h、PPV-6 h、PPV-8 h、PPV-10 h、PPV-12 h),改为仰卧位通气(SPV)后 2 h、4 h(SPV-2 h、SPV-4 h)相关呼吸力学和血流动力学数据,利用 SPSS 19.0 软件进行分析。结果2 例均行有创机械通气;1 例 PPV 前纵隔气肿;症状出现至首次 PPV 分别为 5 d、8 d。共行 12 次 PPV,PPV 13(12~15)h/次,PPV 过程中(PPVmean)氧合指数(OI)较 Pre-PPV 改善[(186.20±71.34)mm Hg 比(131.36±45.43)mm Hg,P=0.020];PPV 过程中(PPVmean)平均动脉压(MAP)较 Pre-PPV 有所下降[(86.84±10.17)mm Hg 比(97.58±20.51)mm Hg,P=0.009]。SPV 后(SPVmean)每小时尿量较 PPV 增多[(100.19±96.73)mL/h 比(52.96±21.64)mL/h,P=0.002]。与 Pre-PPV 对比,OI 以 PPV 10 h 和 12 h 改善为著(P 值分别为 0.009、0.040)。2 例均存活。PPV 过程中未发生深静脉置管滑脱、气管插管意外脱管、气管插管滑入一侧气管、气管插管阻塞。结论PPV 可改善人感染 H7N9 禽流感所致的重度 ARDS 患者的氧合功能,并发症少。

    Release date:2020-07-24 07:00 Export PDF Favorites Scan
  • 仅蒂与肝相连的罕见巨大肝间叶错构瘤1例报道并文献复习

    目的 探讨小儿肝脏间叶错构瘤(mesenchymal hamartoma of liver,MHL)的诊治方法,提高术前诊断率。方法 对2021年11月遵义医科大学附属医院收治的1例5岁女性腹腔占位患儿的临床表现、诊断方法、治疗方案、术后情况及病理结果进行回顾性分析,并进行相关文献复习,总结该疾病的诊治方法。 结果 本例患儿术前检查无特异性,相关检查均未发现肿瘤与肝脏相连接,术前诊断困难,经手术探查发现肿瘤仅由一条索状蒂与肝脏相连接,手术完整切除肿瘤,手术顺利,术后康复出院,术后病理诊断为MHL,出院后随访6个月无复发及恶变。文献复习共32例患儿,其中男25例,女7例;肿瘤仅累及肝右叶21例,累及右叶及左叶4例,仅累及尾状叶3例,仅累及左叶4例;肿瘤与肝脏相融合26例,带蒂与肝脏相连接6例。术前实验室检查部分患儿AFP(9例)或肝功能(AST、ALT,5例)异常,术后均逐渐下降至正常值;主要辅助检查为彩超、CT及MRI,检查发现肿瘤体积普遍较大,肿瘤长径5~20 cm、平均13.4 cm。32例均行手术切除,术前明确诊断为MHL 5例(其中1例术前行穿刺活检证实),术后病理诊断均为MHL;术后恢复良好,其中14例进行了术后随访,随访时间1个月~10年不等,中位随访时间为12个月,均无复发。 结论 对于体积较大的腹腔肿瘤或肝脏肿瘤,在无特异性的检验及检查结果时,应考虑为MHL。手术完全切除是治疗MHL的方法,预后较好,由于肿瘤有复发及恶变的可能性,故术后应定期随访复查。

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