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find Author "杨平" 16 results
  • 胃癌围手术期的营养评估及临床营养支持

    【摘要】 胃癌住院患者营养不良发生率较高,其营养风险比例高。对胃癌患者围手术期营养情况的评定和监测十分重要,有助于改善患者临床结局,减少治疗花费。众多营养状况评估工具适用人群各不相同,应推广和应用基于证据的临床营养支持指南以改善临床营养支持存在不合理性状况。

    Release date:2016-09-08 09:26 Export PDF Favorites Scan
  • 超声诊断隐睾扭转1例

    Release date:2016-09-08 09:56 Export PDF Favorites Scan
  • All Hospitalized Patients Should be Screened for Nutritional Risk in Admission

    Release date:2016-09-08 10:45 Export PDF Favorites Scan
  • 胃癌肿瘤干细胞研究现状及相关问题

    肿瘤干细胞学说是近年来快速发展和备受关注的一个理论,根据该学说,具有自我更新、多向分化、无限生长和很强成瘤能力的癌干细胞可能是肿瘤发生、发展、侵袭和复发转移的根源。当前,已有多种类型的癌干细胞被证实或探讨,然而胃癌干细胞的研究尚存在困难,相关报道很少。现就国内外近年来关于癌干细胞和胃癌干细胞的相关研究进展进行综述,探讨胃癌干细胞的培养、分离、确认鉴定及其复杂的生物学特征研究中尚面临的一些亟待解决的问题。

    Release date:2016-09-08 09:13 Export PDF Favorites Scan
  • Research on Nutritional Risk and Application of Nutrition Support in Hospitalized Patients with Gastric Cancer

    ObjectiveTo investigate the nutritional risk, incidence of malnutrition, and clinical application of nutrition support in hospitalized patients with gastric cancer by the nutritional risk screening (NRS) 2002 score summary table. MethodsFrom June 2009 to February 2010, nutritional risk screen and application of clinical nutritional support were carried out in the hospitalized patients with gastric cancer in this hospital. Nutritional risk was assessed case-by-case according to the severity of illness, nutritional status 〔including body mass index (BMI), recent changes in body weight and eating〕 and patients age. NRS ≥3 was accepted as nutritionally at-risk, while NRS lt;3 no nutritional risk; BMI lt;18.5 kg/m2 (or albumin lt;30 g/L) combined with clinical conditions was judged to be malnourished. Results Three hundreds and eighty-six patients were included, 329 of which completed the NRS2002 screening. One hundred and sixty-five patients (50.15%) were at nutritional risk, while another 164 (49.85%) were no nutritional risk. Malnutrition was found in 57 patients (17.33%). By gender, male malnourished patients and nutritionally at-risk patients were accounting for 16.45% (38/231) and 48.05% (111/231) respectively, while female nutritionally at-risk patients and malnourished patients were accounting for 55.1% (54/98) and 19.39% (19/98) respectively, 72.04% (237/329) of the screened patients accepted clinical nutrition support, among which, 115 patients were at nutritional risk, accounting for 69.70% in that group, and 122 patients were no nutritional risk, accounting for 74.39% in that group. ConclusionsThe incidences of malnutrition and nutritionally at-risk in hospitalized gastric cancer patients are high. And irrationality of clinical nutrition support exists. Evidence-based guidelines are required to improve the nutritional status of support.

    Release date:2016-09-08 10:41 Export PDF Favorites Scan
  • MDM2 –309 T>G Gene Polymorphism and Gastric Cancer Risk in Eastern Asian Population: A Meta-Analysis

    Objective To investigate the correlation between MDM2 SNP309 and gastric cancer (GC) risk in Eastern Asian population. Methods Two reviewers independently searched MEDLINE, EMbase and CBM (from January 1st, 1990 to October 23rd, 2012) for case-control studies on the correlation between MDM2 SNP309 and GC risk in Eastern Asian population. Two reviewers independently screen literature, extracted the data, and assessed the methodological quality. Then meta-analysis was performed using RevMan 5.0 software. Results 5 case-control studies were finally included involving 1 621 GC cases and 2 639 controls. The pooled results showed that the variant homozygote (309GG genotype) was significantly associated with an increased risk of GC as compared to wild-type homozygote (309TT genotype: OR=1.54, 95% CI 1.04 to 2.29, P=0.02). Nevertheless, no association was found in comparison of variant heterozygote (309TG genotype) between wild-homozygote (309TT genotype: OR=1.03, 95% CI 0.75 to 1.42, P=0.006). A significantly increased risk of GC was observed for the recessive model (GG vs. TT/TG: OR=1.49, 95% CI 1.20 to 1.84, P=0.07). While in the dominant model (GG/TG vs. TT), non-significant association was observed (OR=1.18, 95% CI 0.84 to 1.65, P=0.001). Conclusion The MDM2 309GG may be significantly associated with an increased risk of GC among Eastern Asians.

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  • 血浆D-二聚体及纤维蛋白原与糖尿病视网膜病变关系的研究

    Release date:2016-09-02 05:37 Export PDF Favorites Scan
  • 藻酸盐敷料在慢性窦道治疗中的临床观察

    目的探讨藻酸盐敷料在慢性窦道治疗中的临床效果。 方法回顾性分析2011年2月-2015年6月49例慢性窦道患者,其中对照组(传统换药组)26例,采用传统方式换药;试验组(藻酸盐敷料组)23例,应用藻酸盐等创面敷料填塞窦道,形成并维持窦道湿润环境,促进窦道愈合。 结果试验组与对照组平均愈合时间分别为(30.5±4.4)、(37.3±3.7)d,差异有统计学意义(P<0.05);试验组与对照组平均换药次数分别为(10.4±2.7)、(18.7±2.0)次,差异有统计学意义(P<0.05);试验组患者换药时疼痛感较对照组轻,差异有统计学意义(P<0.05)。 结论应用藻酸盐湿性治疗技术治疗慢性窦道,疗效确切,治疗时间短,换药次数少,可减轻患者疼痛,值得临床推广。

    Release date:2016-12-27 11:09 Export PDF Favorites Scan
  • A case report on treatment of compartment syndrome with novel coronavirus pneumonia

    A 49-year-old male patient with compartment syndrome of the right leg caused by acute carbon monoxide poisoning was admitted on December 30, 2019. The patient had a 10-year history of chronic nephritis and began dialysis treatment due to renal failure 1 month ago. Emergency surgical decompression for compartment syndrome was performed after admission. Two weeks later, the patient was diagnosed as the novel coronavirus pneumonia caused by 2019 novel coronavirus (2019-nCoV) infection. Then, the patient was transferred to the isolation ward, where he was given anti-infection, anti-virus, expectorant, heat-clearing and detoxifying drugs, bedside dialysis, and nutrition support symptomatic treatment. After 2 weeks of treatment, the patient is getting better, with no fever, cough, wheezing, and other discomfort. Meanwhile, the sensory and motor functions of right lower limb recovered gradually. This case is rare, severe, and difficult to diagnose and treat. It is the first reported case of novel coronavirus pneumonia after orthopedic surgery.

    Release date:2020-08-19 03:53 Export PDF Favorites Scan
  • EXPERIMENT OF ADIPOSE DERIVED STEM CELLS INDUCED INTO SMOOTH MUSCLE CELLS

    To study the feasibil ity of human adipose derived stem cells (ADSCs) in monolayer culture induced into smooth muscle cells in vitro as seeding cells in vascular tissue engineering. Methods The mononuclear cells in human adipose were separated by collagenase treatment and seeded on culture dishes with the density of 5 × 105/cm2. Cellswere cultured in M-199 plus 10% FBS. When reaching confluence, the cells were subcultured by 0.1% trypsin and 0.02%EDTA treatment, PDGF-BB (50 ng/mL) and TGF-β1 (5 ng/mL) were added at the passage 1 to enhance the smooth muscle cells’ phenotype. Cells were cultured under the inducing medium for 14 days. The morphology of induced cells was observed under the microscope. Cellular immunofluorescence and RT-PCR were used to determine the expression of smooth muscle cell markers of the post-induced cells. Flow cytometry (FACs) was used to examine the positive rate of induced team. Results Cocultured in M-199 media including TGF-β1 and PDGF-BB, the prol iferating capabil ity of the induced cells was significantly downregulated compared with the uninduced cells(P lt; 0.01). The induced cells exhibited “Hill and Valley” morphology, while the uninduced cells were similar to ADSCs of P0 which had the fibroblast-l ike morphology. The results of immunofluorescence indicated that the induced cells expressed smooth muscle (SM) cell- specific markers including α-smooth muscle actin (α-SMA), SM-myosin heavy chain (SM-MHC) and Calponin. The results of RT-PCR revealed that the induced cells also expressed α-SMA, SM-MHC, Calponin and SM-22α.The positive rates of α-SMA, SM-MHC and Calponin in FACs were 3.26% ± 1.31%, 3.55% ± 1.6% and 4.02% ± 1.81%, respectively, before the cells were induced. However, 14 days after the cell induction, the positive rates were 48.13% ± 8.31%, 45.33% ± 10.68% and 39.13% ± 9.42%, respectively. The positive rates in induced cells were remarkably higher than those in uninduced cells(P lt; 0.01). Conclusion The human ADSCs can be induced to express vascular smooth muscle markers, and they are a new potential source of vascular tissue engineering.

    Release date:2016-09-01 09:12 Export PDF Favorites Scan
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