west china medical publishers
Author
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Author "杨文杰" 3 results
  • 家族性渗出性玻璃体视网膜病变致病基因及信号传导途径

    家族性渗出性玻璃体视网膜病变(FEVR)是一种遗传性视网膜血管发育异常的疾病。其遗传方式包括常染色体显性遗传、常染色体隐性遗传和X染色体连锁隐性遗传等3种。其中,常染色体显性遗传主要与Wnt受体Frizzled-4(FZD4)和共受体低密度脂蛋白受体相关蛋白5(LRP5)基因位点突变相关;X染色体隐性遗传主要与Norrie病(NDP)基因突变相关;常染色体隐性遗传主要是LRP5基因位点的突变。3种与FEVR相关的致病基因均与Wnt信号传导途径有紧密关联。位于常染色体7q31的四旋蛋白12(Tspan-12)位点的突变也可以导致FEVR,它参与了Norrin-beta;-catenin信号传导途径。

    Release date:2016-09-02 05:37 Export PDF Favorites Scan
  • Interpretation of CONSORT-Equity 2017 extension: a statement for better reporting of health equity in randomised trials

    CONSORT Group members update the CONSORT (Consolidated Standards of Reporting Trials) statement by collecting relevant literatures to improve the reporting quality of randomised controlled trials. Recently, they have outlined CONSORT-Equity reporting standards, an extension to the CONSORT statement, which had been developed to improve the reporting of intervention effects in randomised trials where health equity is relevant. It will be helpful to improve social health equity or reduce social health inequities. This paper aims to introduce CONSORT-Equity and interprets its usage by a series of randomised trials where health equity is relevant.

    Release date:2019-02-19 03:57 Export PDF Favorites Scan
  • The effect of setting sleep center on understanding obstructive sleep apnea

    ObjectiveTo investigate the knowledge and attitude of medical professionals in various regions of China on obstructive sleep apnea (OSA) and to find out the influence of sleep center setting on the above results.MethodsA self-designed questionnaire based on OSAKA questionnaire was designed. A total of 630 medical staff were investigated in 7 hospitals at different levels in various regions in China. The subjects were divided into two groups according to whether they had sleep center (including sleep monitoring room) or not. Survey data were analyzed.ResultsA total of 630 questionnaires were sent out, and 590 valid questionnaires were received, and the effective response rate was 93.65%. About half of those surveyed had sleep centers in the hospitals where they worked. There was no significant difference in three attitude problems and the choice of continuous positive airway pressure and surgical treatment between the two groups (all P>0.05). Subjects whose hospital had no sleep center were more prone to select weight loss (estimated parameters=0.513, P=0.046), no smoking and wine (estimated parameter=0.472, P=0.040), avoidance of overwork (estimated parameter=0.933, P=0.000), and drug (estimated parameter=0.802, P=0.000). The average correct rate of OSA knowledge was 45.59%±20.68%. Among them, the correct rate of response to treatment measures was the highest, and the correct rate of other knowledge points was poor. The average correct rate of total accuracy, symptoms and target organ damage in subjects whose hospital had sleep center was higher than that in subjects whose hospital had no sleep center, and there were significant differences (P=0.001, P=0.012, P=0.000). There was a positive correlation between the knowledge of OSA and their attitude towards OSA, treatment and further understanding of the knowledge (r=0.247, P=0.000).ConclusionIt is necessary to strengthen propaganda and education of OSA, and the establishment of sleep center is helpful for medical personnel to know more about OSA and to develop sleep medicine.

    Release date:2019-09-25 09:48 Export PDF Favorites Scan
1 pages Previous 1 Next

Format

Content